4-BROMO-2-METHYLBENZYLAMINE
- Product Name
- 4-BROMO-2-METHYLBENZYLAMINE
- CAS No.
- 376646-62-7
- Chemical Name
- 4-BROMO-2-METHYLBENZYLAMINE
- Synonyms
- (4-BroMo-2-Methylphenyl)MethanaMine;RARECHEM AL BW 0436;(4-Bromo-2-methylphenyl);4-BROMO-2-METHYLBENZYLAMINE;4-bromo-2-methylbenzylaminie;4-Bromo-2-methylbenzenemethanamine;Benzenemethanamine, 4-bromo-2-methyl-;1-(4-bromo-2-methylphenyl)methanamine
- CBNumber
- CB9383924
- Molecular Formula
- C8H10BrN
- Formula Weight
- 200.08
- MOL File
- 376646-62-7.mol
4-BROMO-2-METHYLBENZYLAMINE Property
- Boiling point:
- 270.9±25.0 °C(Predicted)
- Density
- 1.410±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.03±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
- Sensitive
- Air Sensitive
- InChI
- InChI=1S/C8H10BrN/c1-6-4-8(9)3-2-7(6)5-10/h2-4H,5,10H2,1H3
- InChIKey
- CRDQDMSHRCFAAW-UHFFFAOYSA-N
- SMILES
- C1(CN)=CC=C(Br)C=C1C
Safety
- Hazard Codes
- T
N-Bromosuccinimide Price
- Product number
- 9535AF
- Product name
- (4-Bromo-2-methylphenyl)methanamine
- Packaging
- 5g
- Price
- $391
- Updated
- 2021/12/16
- Product number
- HCH0012911
- Product name
- 4-BROMO-2-METHYLBENZYLAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.93
- Updated
- 2021/12/16
- Product number
- SC-13090
- Product name
- 4-Bromo-2-methylbenzylamine
- Purity
- 95
- Packaging
- 10g
- Price
- $647
- Updated
- 2021/12/16
- Product number
- 61-11154
- Product name
- (4-Bromo-2-methylphenyl)methanamine
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $700
- Updated
- 2021/12/16
- Product number
- 376646627
- Product name
- 4-Bromo-2-methylbenzylamine
- Packaging
- 500mg
- Price
- $823.15
- Updated
- 2021/12/16
4-BROMO-2-METHYLBENZYLAMINE Chemical Properties,Usage,Production
Synthesis
67832-11-5
376646-62-7
Under nitrogen protection, 4-bromo-2-methylbenzonitrile (3.0 g, 15 mmol) was dissolved in anhydrous tetrahydrofuran (20 mL) and cooled to 0 °C. A tetrahydrofuran solution (46 mL) of 1.0 M borane was added slowly, keeping the reaction temperature at 0 °C. The reaction mixture was stirred at 0 °C for 1 h before being warmed to 80 °C and heated overnight. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched by slow addition of methanol and subsequently concentrated under vacuum. The crude product was treated with ethyl acetate (20 mL) and a 1,4-dioxane solution (8.0 mL, 32 mmol) of 4 M hydrochloric acid for 5 min. The solid was collected by filtration, washed with ether and dried to give 4-bromo-2-methylbenzenemethanamine as a white powder (3.24 g, yield: 100%). Liquid chromatography-mass spectrometry (LCMS) analysis: retention time (RT) 0.75 min, molecular ion peak (MH+) 200.0. nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, DMSO-d6) δ: 8.28 (broad single peak, 2H), 7.42-7.54 (multiple peaks, 2H), 7.34 (double peak, J = 7.93 Hz, 1H) , 3.99 (double peak, J = 4.15 Hz, 2H), 2.35 (single peak, 3H).
References
[1] Patent: WO2015/89337, 2015, A1. Location in patent: Paragraph 0617
[2] Patent: WO2016/201271, 2016, A1. Location in patent: Paragraph 0114
[3] Patent: WO2015/89327, 2015, A1. Location in patent: Paragraph 0195
4-BROMO-2-METHYLBENZYLAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
4-BROMO-2-METHYLBENZYLAMINE Suppliers
- Tel
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- Fax
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- contact@achemica.com
- Country
- Switzerland
- ProdList
- 6155
- Advantage
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