ChemicalBook > CAS DataBase List > 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE

4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE

Product Name
4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE
CAS No.
106691-21-8
Chemical Name
4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE
Synonyms
AKOS 92593;4-Chloro-6-Methylthieno[2...;4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE;Thieno[2,3-d]pyrimidine, 4-chloro-6-methyl-;4-chloro-6-methylthieno[2,3-d]pyrimidine(SALTDATA: FREE);4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
CBNumber
CB9385175
Molecular Formula
C7H5ClN2S
Formula Weight
184.65
MOL File
106691-21-8.mol
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4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE Property

Melting point:
88-91℃ (sublm)
Boiling point:
301.3±37.0 °C(Predicted)
Density 
1.445±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0.56±0.40(Predicted)
Appearance
light yellow solid
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Safety

Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C367573
Product name
4-Chloro-6-methylthieno[2,3-d]pyrimidine
Packaging
50mg
Price
$45
Updated
2021/12/16
AK Scientific
Product number
X3464
Product name
4-Chloro-6-methylthieno[2,3-d]pyrimidine
Packaging
10g
Price
$1269
Updated
2021/12/16
Oakwood
Product number
021442
Product name
4-Chloro-6-methylthieno[2,3-d]pyrimidine
Packaging
25g
Price
$1750
Updated
2021/12/16
AK Scientific
Product number
X3464
Product name
4-Chloro-6-methylthieno[2,3-d]pyrimidine
Packaging
2.5g
Price
$467
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0320069
Product name
4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE
Purity
95.00%
Packaging
5MG
Price
$500.03
Updated
2021/12/16
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4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE Chemical Properties,Usage,Production

Synthesis

108831-66-9

106691-21-8

GENERAL METHOD: A mixture of 6-methyl-3H-thieno[2,3-d]pyrimidin-4-one (0.01 mol), phosphorus trichloride (11 mL), and phosphorus pentachloride (1.5 g) was rapidly heated to 105°C and the reaction was carried out at reflux for 5-6 hours. After completion of the reaction, excess solvent was removed by distillation under reduced pressure. The crude product was dissolved in dichloromethane (12 mL) and neutralized with cold sodium hydroxide solution (0.5 N). The organic phase was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was recrystallized with isopropanol to afford the target product 4-chloro-6-methylthieno[2,3-d]pyrimidine in 80% yield.

References

[1] Pharmaceutical Chemistry Journal, 1987, vol. 21, # 2, p. 126 - 129
[2] Khimiko-Farmatsevticheskii Zhurnal, 1987, vol. 21, # 2, p. 197 - 200
[3] European Journal of Medicinal Chemistry, 2016, vol. 115, p. 148 - 160
[4] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 2, p. 305 - 308
[5] European Journal of Medicinal Chemistry, 2011, vol. 46, # 3, p. 870 - 876

4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE Suppliers

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View Lastest Price from 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE 106691-21-8
Price
US $1.10/g
Min. Order
1g
Purity
99.0% min
Supply Ability
100 tons min
Release date
2021-11-24
Career Henan Chemical Co
Product
4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE 106691-21-8
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-14

106691-21-8, 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINERelated Search:

4-CHLORO-6,7-DIHYDRO-5H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-7-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-5,6-DIMETHYLTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2,5,6-TRIMETHYLTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-6-ETHYLTHIENO[2,3-D]PYRIMIDINE 7-TERT-BUTYL-4-CHLORO-5,6,7,8-TETRAHYDRO-BENZO[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-5,6,7,8-TETRAHYDROBENZO[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-6-PHENYLTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-PYRIDIN-3-YL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE 4-CHLORO-5-METHYL-6-PHENYLTHIENO[2,3-D]PYRIMIDINE ETHYL 4-CHLORO-5-METHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLOROTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE ETHYL 4-CHLORO-2,5-DIMETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXYLATE 4-CHLORO-2-METHYL-6-PHENYL-THIENO[2,3-D]PYRIMIDINE 4-CHLORO-6-METHYL-2,3-DIHYDRO-1H-8-THIA-5,7-DIAZA-CYCLOPENTA[A]INDENE 4-CHLORO-2-ETHYL-6,7-DIHYDRO-5H-CYCLOPENTA[4,5]THIENO[2,3-D]PYRIMIDINE 4-CHLORO-2-ETHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE

  • 4-chloro-6-methylthieno[2,3-d]pyrimidine(SALTDATA: FREE)
  • 4-Chloro-6-Methylthieno[2...
  • AKOS 92593
  • 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE
  • Thieno[2,3-d]pyrimidine, 4-chloro-6-methyl-
  • 4-CHLORO-6-METHYLTHIENO[2,3-D]PYRIMIDINE ISO 9001：2015 REACH
  • 106691-21-8