Benznidazole
- Product Name
- Benznidazole
- CAS No.
- 22994-85-0
- Chemical Name
- Benznidazole
- Synonyms
- ro71051;radanil;Rochagan;Aids007909;NSC 299972;Ro 07-1051;Aids-007909;Benznidazol;benznidazole;Benzonidazol
- CBNumber
- CB9390906
- Molecular Formula
- C12H12N4O3
- Formula Weight
- 260.25
- MOL File
- 22994-85-0.mol
Benznidazole Property
- Melting point:
- 189-192 °C (lit.)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- methanol: soluble50mg/mL, clear, colorless to yellow
- form
- Solid
- pka
- 14?+-.0.46(Predicted)
- color
- White to Off-White
- Water Solubility
- 0.4g/L(temperature not stated)
- Merck
- 13,1085
- BCS Class
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 419656
- Product name
- N-Benzyl-2-nitro-1H-imidazole-1-acetamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $262
- Updated
- 2024/03/01
- Product number
- 29090
- Product name
- Benznidazole
- Packaging
- 25mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 29090
- Product name
- Benznidazole
- Packaging
- 250mg
- Price
- $723
- Updated
- 2024/03/01
- Product number
- 29090
- Product name
- Benznidazole
- Packaging
- 50mg
- Price
- $198
- Updated
- 2024/03/01
- Product number
- 29090
- Product name
- Benznidazole
- Packaging
- 100mg
- Price
- $352
- Updated
- 2024/03/01
Benznidazole Chemical Properties,Usage,Production
Description
Benznidazole is the second of the drugs approved for treatment of Chagas' disease. Like nifurtimox, it is effective against the circulating form of Trypanosoma cruzi during the acute phase of the disease, but also like nifurtimox, it is ineffective during the chronic stage of the disease.
Description
Benznidazole is an orally bioavailable antiprotozoal agent. It is a 2-nitroimidazole prodrug that becomes active when the nitro group is reduced within the parasite. It inhibits the growth of the parasites T. cruzi, T. vaginalis, G. lamblia, and E. histolytica (IC50s = 8.1, 18.62, 22.58, and 4.27 μM, respectively). It also inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic, but not normoxic, conditions when used at a concentration of 100 μM. Benznidazole (100 mg/kg per day) decreases T. cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease. Formulations containing benznidazole have been used in the treatment of Chagas disease caused by T. cruzi.
Uses
N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) may be used as reference drug for the extraction of guaianolide from the aerial parts of Tanacetum parthenium and to evaluate its in vitro antiprotozoal activity.
Uses
Benznidazole (BNZ) is traditionally used to treat Chagas disease caused by Trypanosoma cruzi. The drugs used for the treatment of this disease, Nifurtimox and Benznidazole, are toxic and present sever e side effects.
Definition
ChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.
Antimicrobial activity
It exhibits antiprotozoal activity, particularly against Trypanosoma cruzi.
General Description
N-Benzyl-2-nitro-1H-imidazole-1-acetamide (Benznidazole) is a nitro-heterocyclic compound. It is widely employed drug for the treatment of Chagas disease. It exhibits three polymorphic forms..
Pharmaceutical Applications
A synthetic 2-nitroimidazole, formulated for oral administration. Solubility in water 400 mg/L.
Mechanism of action
Studies suggest that benznidazole does not catalyze the formation of ROS and, therefore, has a mechanism of action different from that of nifurtimox. It has been proposed that benznidazole undergoes an one-electron transfer to the nitro group, which in turn dismutates to give back the nitroimidazole and a nitrosoimidazole. The latter product may then undergo an electrophilic addition to trypanothione, which leads to depletion of trypanothione, an essential enzyme system in the Trypanosoma cruzi.
Pharmacokinetics
Oral bioavailability :High
Cmax 100 mg oral ：2.2–2.8 mg/L after 3–4 h
Plasma half-life：10.5–13.6 h
Volume of distribution：c. 0.56 L/kg
Plasma protein binding： c. 44%
The 2-nitro group undergoes reduction to the amine and hydrolysis to the hydroxy derivative.
Clinical Use
N-Benzyl-2-nitroimidazole-1-acetamide (Radanil, Rochagan)is a nitroimidazole derivative that is used for the treatment ofChagas disease. It is not available in the United States but isused extensively in South America. The effectiveness of benznidazoleis similar to that of nifurtimox. Therapy forAmerican trypanosomiasis with oral benznidazole requiresseveral weeks and is frequently accompanied by adverse effectssuch as peripheral neuropathy, bone marrow depression,and allergic-type reactions.
Clinical Use
Benznidazole is used in treatment of South American trypanosomiasis (Chagas disease).
Side effects
Adverse effects are more common in the elderly and include nausea, vomiting, abdominal pain, peripheral neuropathy and severe skin reactions.
Benznidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Benznidazole manufacturers
- Product
- Benznidazole 22994-85-0
- Price
- US $3.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10 tons
- Release date
- 2024-04-02
- Product
- Benznidazole 22994-85-0
- Price
- US $35.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 200tons/year
- Release date
- 2024-03-12
- Product
- Benznidazole 22994-85-0
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25