1-methyl-2-nitroimidazole

Product Name: 1-methyl-2-nitroimidazole
CAS No.: 1671-82-5
Chemical Name: 1-methyl-2-nitroimidazole
Synonyms: 129542;1-methyl-2-nitroimidazole;2-Nitro-1-methylimidazole;-methyl-2-nitro-1H-imidazole;1-Methyl-2-nitro-1H-imidazole;1H-IMidazole,1-Methyl-2-nitro-;1H-Pyrazole,5-bromo-1-(tetrahydro-2H-pyran-7-yl)-
CBNumber: CB31380300
Molecular Formula: C4H5N3O2
Formula Weight: 127.1
MOL File: 1671-82-5.mol

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1-methyl-2-nitroimidazole Property

Melting point:: 100-102 °C
Boiling point:: 235.85°C (rough estimate)
Density: 1.4748 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: 2-8°C
pka: 1.10±0.25(Predicted)
Appearance: Off-white to yellow Solid
InChI: InChI=1S/C4H5N3O2/c1-6-3-2-5-4(6)7(8)9/h2-3H,1H3
InChIKey: HBMINVNVQUDERA-UHFFFAOYSA-N
SMILES: C1([N+]([O-])=O)N(C)C=CN=1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H315Causes skin irritation

H317May cause an allergic skin reaction

H318Causes serious eye damage

H335May cause respiratory irritation

H350May cause cancer

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: M341035
Product name: 1-Methyl-2-nitro-1H-imidazole
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: M341035
Product name: 1-Methyl-2-nitro-1H-imidazole
Packaging: 50mg
Price: $90
Updated: 2021/12/16

Matrix Scientific

Product number: 133232
Product name: 1-Methyl-2-nitro-1H-imidazole
Purity: 97%
Packaging: 500mg
Price: $339
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0125676
Product name: 1-METHYL-2-NITROIMIDAZOLE
Purity: 95.00%
Packaging: 5MG
Price: $498.38
Updated: 2021/12/16

AK Scientific

Product number: 8515AA
Product name: 1-Methyl-2-nitro-1H-imidazole
Packaging: 10g
Price: $872
Updated: 2021/12/16

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1-methyl-2-nitroimidazole Chemical Properties,Usage,Production

Synthesis

527-73-1

74-88-4

1671-82-5

GENERAL STEPS: Cesium carbonate (Cs2CO3, 4.3 g, 13.3 mmol) was added to a stirred N,N-dimethylformamide (DMF, 6 mL) solution of 2-nitro-1H-imidazole (500 mg, 4.42 mmol) under nitrogen protection. Subsequently, iodomethane (Mel, 942 mg, 6.63 mmol) was slowly added to the reaction system. The resulting mixture was stirred and reacted at 50 °C overnight. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate (NaHCO3) and extracted with ethyl acetate (EA, 25 mL x 3). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel, eluent: petroleum ether/ethyl acetate, 0-50% gradient) to afford 1-methyl-2-nitro-1H-imidazole (542-1) (530 mg, 100% yield) as a yellow solid. lC-MS (ESI): m/z [M + H]+ 128.1.

References

[1] Patent: WO2016/4272, 2016, A1. Location in patent: Paragraph 00798

1-methyl-2-nitroimidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-methyl-2-nitroimidazole Suppliers

China 38 Germany 1 India 2 South Korea 1 Switzerland 1 United States 3 Global 46

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2-Nitro-1-methylimidazole

1-methyl-2-nitroimidazole

1-Methyl-2-nitro-1H-imidazole

1H-IMidazole,1-Methyl-2-nitro-

129542

1H-Pyrazole,5-bromo-1-(tetrahydro-2H-pyran-7-yl)-

-methyl-2-nitro-1H-imidazole

1671-82-5