misonidazole
- Product Name
- misonidazole
- CAS No.
- 13551-87-6
- Chemical Name
- misonidazole
- Synonyms
- SRI-1354;Ro 7-0582;Ro-07-0582;NSC-261037;Aids028846;Aids-028846;misonidazole;1-(2-NITRO-1-IMIDAZOLYL-1)3-METHOXYPROPANOL;α-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol;1-Methoxy-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol
- CBNumber
- CB4876199
- Molecular Formula
- C7H11N3O4
- Formula Weight
- 201.181
- MOL File
- 13551-87-6.mol
misonidazole Property
- Melting point:
- 107-109°C
- Boiling point:
- 339.09°C (rough estimate)
- Density
- 1.3983 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 13.49±0.20(Predicted)
- color
- Yellow to Orange
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 15606
- Product name
- Misonidazole
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 15606
- Product name
- Misonidazole
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $107
- Updated
- 2024/03/01
- Product number
- 15606
- Product name
- Misonidazole
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $151
- Updated
- 2024/03/01
- Product number
- 15606
- Product name
- Misonidazole
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $357
- Updated
- 2024/03/01
- Product number
- M368700
- Product name
- Misonidazole
- Packaging
- 100mg
- Price
- $180
- Updated
- 2021/12/16
misonidazole Chemical Properties,Usage,Production
Description
Misonidazole is a nitroimidazole with radiosensitizing and antineoplastic properties. Nitroimidazoles, including misonidazole, specifically accumulate as nitro anion radicals and their metabolites in hypoxic cells. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells. Misonidazole and derivatives, including fluoromisonidazole, are used in the imaging of hypoxic regions in tumors and in the cardiovascular system.
Uses
Antiprotozoal (Trichomonas).
Uses
Misonidazole can be used as a potential hypoxic cancer cell radiosensitizer and DNA binding and nicking agent. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells
in vitro
in cultured cho cells, pretreatment with 5 mm miso for 2 hr exihibited the marginal toxicity [2].
in vivo
pretreatment with misonidazole (miso) enhanced the number of cross-links formed in a fibrosarcoma and in the spleen and gut of mice for periods up to 48 h following a single injection of melphalan (mel). miso pretreatment could result in a greater amount of binding of mel to dna at early times after injection. miso may exert its affect by inhibiting the repair of cross-links or monoadducts at early times post-injection [3].
References
[1] josephy p d, palcic b, skarsgard l d. ascorbate-enhanced cytotoxicity of misonidazole[j]. nature, 1978, 271(5643): 370-372.
[2]taylor y c, bump e a, brown j m. studies on the mechanism of chemosensitization by misonidazole in vitro[j]. international journal of radiation oncology biology physics, 1982, 8(3-4): 705-708.
[3] murray d, meyn r e. enhancement of the dna cross-linking activity of melphalan by misonidazole in vivo[j]. british journal of cancer, 1983, 47(2): 195.
[4] wasserman t h, stetz j a, phillips t l.
misonidazole Preparation Products And Raw materials
Raw materials
Preparation Products
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