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misonidazole

Product Name
misonidazole
CAS No.
13551-87-6
Chemical Name
misonidazole
Synonyms
SRI-1354;Ro 7-0582;Ro-07-0582;NSC-261037;Aids028846;Aids-028846;misonidazole;1-(2-NITRO-1-IMIDAZOLYL-1)3-METHOXYPROPANOL;α-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol;1-Methoxy-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol
CBNumber
CB4876199
Molecular Formula
C7H11N3O4
Formula Weight
201.181
MOL File
13551-87-6.mol
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misonidazole Property

Melting point:
107-109°C
Boiling point:
339.09°C (rough estimate)
Density 
1.3983 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly, Heated), Methanol (Slightly, Sonicated)
form 
Solid
pka
13.49±0.20(Predicted)
color 
Yellow to Orange
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15606
Product name
Misonidazole
Purity
≥95%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
15606
Product name
Misonidazole
Purity
≥95%
Packaging
5mg
Price
$107
Updated
2024/03/01
Cayman Chemical
Product number
15606
Product name
Misonidazole
Purity
≥95%
Packaging
10mg
Price
$151
Updated
2024/03/01
Cayman Chemical
Product number
15606
Product name
Misonidazole
Purity
≥95%
Packaging
50mg
Price
$357
Updated
2024/03/01
TRC
Product number
M368700
Product name
Misonidazole
Packaging
100mg
Price
$180
Updated
2021/12/16
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misonidazole Chemical Properties,Usage,Production

Description

Misonidazole is a nitroimidazole with radiosensitizing and antineoplastic properties. Nitroimidazoles, including misonidazole, specifically accumulate as nitro anion radicals and their metabolites in hypoxic cells. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells. Misonidazole and derivatives, including fluoromisonidazole, are used in the imaging of hypoxic regions in tumors and in the cardiovascular system.

Uses

Antiprotozoal (Trichomonas).

Uses

Misonidazole can be used as a potential hypoxic cancer cell radiosensitizer and DNA binding and nicking agent. The metabolites of misonidazole can themselves be cytotoxic or they can increase the chemosensitivity and radiosensitivity of the target cells

in vitro

in cultured cho cells, pretreatment with 5 mm miso for 2 hr exihibited the marginal toxicity [2].

in vivo

pretreatment with misonidazole (miso) enhanced the number of cross-links formed in a fibrosarcoma and in the spleen and gut of mice for periods up to 48 h following a single injection of melphalan (mel). miso pretreatment could result in a greater amount of binding of mel to dna at early times after injection. miso may exert its affect by inhibiting the repair of cross-links or monoadducts at early times post-injection [3].

References

[1] josephy p d, palcic b, skarsgard l d. ascorbate-enhanced cytotoxicity of misonidazole[j]. nature, 1978, 271(5643): 370-372.
[2]taylor y c, bump e a, brown j m. studies on the mechanism of chemosensitization by misonidazole in vitro[j]. international journal of radiation oncology biology physics, 1982, 8(3-4): 705-708.
[3] murray d, meyn r e. enhancement of the dna cross-linking activity of melphalan by misonidazole in vivo[j]. british journal of cancer, 1983, 47(2): 195.
[4] wasserman t h, stetz j a, phillips t l.

misonidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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13551-87-6, misonidazoleRelated Search:


  • misonidazole
  • 1-(2-NITRO-1-IMIDAZOLYL-1)3-METHOXYPROPANOL
  • NSC-261037
  • Ro 7-0582
  • Ro-07-0582
  • SRI-1354
  • α-(Methoxymethyl)-2-nitro-1H-imidazole-1-ethanol
  • 1H-Imidazole-1-ethanol, .alpha.-(methoxymethyl)-2-nitro-
  • Aids028846
  • Aids-028846
  • 1-Methoxy-3-(2-nitro-1H-imidazol-1-yl)propan-2-ol
  • 1H-Imidazole-1-ethanol, α-(methoxymethyl)-2-nitro-
  • SR 1354,Misonidazole,antimicrobial,Inhibitor,antiprotozoal,radiation sensitizer,Ro 7-0582,SR1354,Bacterial,inhibit,SR-1354
  • 13551-87-6