2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- Product Name
- 2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- CAS No.
- 115029-23-7
- Chemical Name
- 2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- Synonyms
- RARECHEM AL BO 0633;2-Fluoro-5-trifluoromethylbenz;à,à,à,6-tetrafluoro-m-toluic acid;2-fluoro-5-(trifluoromethyl)benzoic;2-FLUORO-5-TRIFLUOROMETHYLBENZIOC ACID;2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID;2-Fluoro-5-(trifluoromethyl)benzoicacid98%;2-Fluoro-5-(trifluoromethyl)benzoicAcid>Benzoic acid, 2-fluoro-5-(trifluoromethyl)-;2-Fluoro-5-(trifluoromethyl)benzoic acid 98%
- CBNumber
- CB9397309
- Molecular Formula
- C8H4F4O2
- Formula Weight
- 208.11
- MOL File
- 115029-23-7.mol
2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Property
- Melting point:
- 100-103 °C (lit.)
- Boiling point:
- 236℃
- Density
- 1.489
- Flash point:
- 96℃
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly),
- pka
- 2.84±0.10(Predicted)
- form
- Solid
- color
- Off-White to Pale Beige
- BRN
- 5813056
- InChI
- InChI=1S/C8H4F4O2/c9-6-2-1-4(8(10,11)12)3-5(6)7(13)14/h1-3H,(H,13,14)
- InChIKey
- LIFKXWNFWIUMJT-UHFFFAOYSA-N
- SMILES
- C(O)(=O)C1=CC(C(F)(F)F)=CC=C1F
- CAS DataBase Reference
- 115029-23-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 455253
- Product name
- 2-Fluoro-5-(trifluoromethyl)benzoic acid
- Purity
- 98%
- Packaging
- 5g
- Price
- $50.6
- Updated
- 2023/06/20
- Product number
- F0620
- Product name
- 2-Fluoro-5-(trifluoromethyl)benzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- F0620
- Product name
- 2-Fluoro-5-(trifluoromethyl)benzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $80
- Updated
- 2025/07/31
- Product number
- F598475
- Product name
- 2-Fluoro-5-(trifluoromethyl)benzoic Acid
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- A997
- Product name
- 2-Fluoro-5-(trifluoromethyl)benzoic Acid
- Packaging
- 25g
- Price
- $87
- Updated
- 2021/12/16
2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Synthesis Reference(s)
Tetrahedron Letters, 33, p. 7495, 1992 DOI: 10.1016/S0040-4039(00)60805-5
Synthesis
402-44-8
115029-23-7
General procedure for the synthesis of 2-fluoro-5-trifluoromethylbenzoic acid from 4-fluorobenzotrifluoride: 99 g (0.6 mol) of 4-fluorobenzotrifluoride was dissolved in 750 ml of tetrahydrofuran at -60 °C and protected by nitrogen, and 256 ml (0.64 mol) of a 2.5 M butyl lithium hexane solution was added slowly dropwise over a controlled period of time. The reaction mixture was stirred continuously at -60 °C to -70 °C for 4 h and subsequently poured into a large excess of dry ice. after 15 min, the excess dry ice was evaporated by external heating and the solvent was removed by rotary evaporator. The residue was dissolved in 500 ml of water, 30 ml of 1N sodium hydroxide solution was added and washed with 2 x 300 ml of ethyl acetate. The aqueous phase was acidified with concentrated hydrochloric acid and then extracted with 2 x 300 ml ethyl acetate. The organic phases were combined and washed sequentially with 500 ml of water and 300 ml of saturated saline, dried over anhydrous sodium sulfate and concentrated by rotary evaporation. The crude product was recrystallized by hexane to give 80 g of white analytically pure crystals with 64% yield and melting point of 205°C. The product was extracted with 500 ml of water and 300 ml of saturated saline. Elemental analysis results (C8H4O2F4): calculated value C 46.17%, H 1.94%; measured value C 46.16%, H 1.89%.
References
[1] Patent: US4705853, 1987, A
[2] Patent: US5304532, 1994, A
2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Suppliers
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- 320-37350700
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- +32 (0)37350701
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View Lastest Price from 2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID manufacturers
- Product
- 2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID 115029-23-7
- Price
- US $420.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20 tons
- Release date
- 2019-12-24
- Product
- 2-Fluoro-5-Trifluoromethylbenzoic Acid 115029-23-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-14
- Product
- 2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID 115029-23-7
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12