DEXCHLORPHENIRAMINE

Product Name: DEXCHLORPHENIRAMINE
CAS No.: 25523-97-1
Chemical Name: DEXCHLORPHENIRAMINE
Synonyms: C06946;fortamine;isomerine;chlo-amine;phendextro;Mylaramine;S-Chlorpheniramine;d-chlorpheniramine;exchlorpheniramine;DEXCHLORPHENIRAMINE
CBNumber: CB9399974
Molecular Formula: C16H19ClN2
Formula Weight: 274.79
MOL File: 25523-97-1.mol

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DEXCHLORPHENIRAMINE Property

alpha: D25 +49.8° (c = 1 in DMF)
Boiling point:: 142 °C(Press: 1.0 Torr)
Density: 1.107±0.06 g/cm3(Predicted)
pka: 9.33±0.28(Predicted)

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Safety

Hazardous Substances Data: 25523-97-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0006290
Product name: (+)-CHLORPHENIRAMINE
Purity: 95.00%
Packaging: 1G
Price: $668.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006290
Product name: (+)-CHLORPHENIRAMINE
Purity: 95.00%
Packaging: 5G
Price: $898.31
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0006290
Product name: (+)-CHLORPHENIRAMINE
Purity: 95.00%
Packaging: 10G
Price: $1280.79
Updated: 2021/12/16

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DEXCHLORPHENIRAMINE Chemical Properties,Usage,Production

Originator

Polaramine,Schering,US,1958

Uses

Antihistaminic.

Uses

Activity of this drug is approximately twice that of chlorpheniramine. Dexchlorpheniramine is also used for allergy symptoms, rhinitis, and dermatitis.

Definition

ChEBI: Dexchlorpheniramine is a chlorphenamine. It is an enantiomer of a levochlorpheniramine.

Manufacturing Process

Twenty grams of d-phenylsuccinic acid and 28 grams of 3-(2-pyridyl)-3-pchlorophenyl-N,N-dimethylpropylamine are dissolved in 400 ml of absolute ethyl alcohol and allowed to stand at room temperature until crystallization is effected. The crystals are filtered, washed with absolute ethyl alcohol and recrystallized from 300 ml of this solvent in the same manner. The crystals are recrystallized twice from 80% ethyl alcohol using 3.5 ml per gram of compound in the manner described above and pure d-3-(2-pyridyl)-3-pchlorophenyl-N,Ndimethylpropylamine-d-phenylsuccinate is obtained, melting point 145-147°C.
This salt is shaken with 100 ml of diethyl ether and 50 ml of 20% aqueous potassium carbonate; the ether layer is separated, dried over anhydrous potassium carbonate, filtered and the ether is removed in vacuo. The d-3-(2- pyridyl)-3-p-chlorophenyl-N,N-dimethylpropylamine so obtained is a mobile oil.
4.3 grams of the above base and 1.8 grams of maleic acid are dissolved in 20 ml isopropyl acetate and kept at room temperature until crystallization is complete. The crystals are filtered, washed with ethyl acetate and recrystallized from 15 ml of this solvent in the same manner. The crystalline d-3-(2-pyridyl)-3-p-chlorophenyl-N,N-dimethylpropylamine maleate so formed is then filtered off and dried. MP 113-115°C from US Patent 3,030,371.

brand name

Mylaramine (Morton Grove); Polaramine (Schering).

Therapeutic Function

Antihistaminic

DEXCHLORPHENIRAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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DEXCHLORPHENIRAMINE Suppliers

China 10 Europe 1 India 3 South Korea 1 United Kingdom 3 United States 8 Global 26

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19885
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

Waterstone Technology, LLC

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Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

2A PharmaChem USA

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Email: sales@2apharmachem.com
Country: United States
ProdList: 6137
Advantage: 39

3B Scientific Corporation

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Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

HONEST JOY HOLDINGS LIMITED

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Email: sales@honestjoy.cn
Country: United States
ProdList: 6675
Advantage: 54

American Custom Chemicals Corporation

Tel: --
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Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

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View Lastest Price from DEXCHLORPHENIRAMINE manufacturers

Hebei Chuanghai Biotechnology Co,.LTD

Product: Chlorpheniramine maleate 25523-97-1
Price: US $10.50/KG
Min. Order: 1KG
Purity: 99
Supply Ability: 1 ton
Release date: 2024-08-20

25523-97-1, DEXCHLORPHENIRAMINERelated Search:

HexanitrodiphenylaMine BROMPHENIRAMINE MALEATE IMP. B (EP) AS MALEATE: DEXCHLORPHENIRAMINE MALEATE IMP. B (EP): DEXCHLORPHENIRAMINE CL DEXCHLORPHENIRAMINE TANNATE DEXCHLORPHENIRAMINE MALEATE IMP. A (EP) AS MALEATE: (3RS)-N,N-DIMETHYL-3-PHENYL-3-(PYRIDIN-2-YL)PROPAN-1-AMINE MALEATE Dexchlorpheniramine Maleate Pheniramine maleate DEXCHLORPHENIRAMINE

chlo-amine

2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (γS)-

Pyridine, 2-[p-chloro-α-[2-(dimethylamino)ethyl]benzyl]-, (S)-(+)- (8CI)

S-(+)-Chlorpheniramine

S-Chlorpheniramine

Dexchlorpheniramine (base and/or unspecified salts)

(+)-2-[(S)-p-Chloro-α-[2-(dimethylamino)ethyl]benzyl]pyridine

(S)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropan-1-amine

C06946

(3S)-3-(4-Chlorophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine

d-2-[p-chloro-alpha-(2-dimethylaminoethyl)benzyl]pyridine

d-chlorpheniramine

fortamine

isomerine

n-dimethyl-gamma-(4-chlorophenyl)-(s)-2-pyridinepropanamin

phendextro

DEXCHLORPHENIRAMINE

DEXCHLORPHENIRAMINE BASE

(S)-Chloropheniramine

2-Pyridinepropanamine, γ-(4-chlorophenyl)-N,N-dimethyl-, (S)-

(3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine

exchlorpheniramine

DEXCHLORPHENIRAMINE USP/EP/BP

Dexchlorpheniramine free base

Mylaramine

25523-97-1

C16H19ClN2