Pheniramine maleate
- Product Name
- Pheniramine maleate
- CAS No.
- 132-20-7
- Chemical Name
- Pheniramine maleate
- Synonyms
- Pheneramine Maleate;PHENIRAMINE MALEATE SALT;pm241;Fervex;daneral;ho11513;inhiston;Trimetose;205-051-4;Antolozine
- CBNumber
- CB9727768
- Molecular Formula
- C20H24N2O4
- Formula Weight
- 356.42
- MOL File
- 132-20-7.mol
Pheniramine maleate Property
- Melting point:
- 104-108°C
- Boiling point:
- 489.25°C (rough estimate)
- Density
- 1.2233 (rough estimate)
- refractive index
- 1.6800 (estimate)
- storage temp.
- 2-8°C
- solubility
- Very soluble in water, freely soluble in ethanol (96 per cent), in methanol and in methylene chloride.
- color
- White
- Water Solubility
- >=1 g/100 mL at 24 ºC
- λmax
- 262nm(lit.)
- Merck
- 14,7235
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- CAS DataBase Reference
- 132-20-7(CAS DataBase Reference)
- EPA Substance Registry System
- Pheniramine maleate (132-20-7)
N-Bromosuccinimide Price
- Product number
- PHR2646
- Product name
- Pheniramine Maleate
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 300MG
- Price
- $200
- Updated
- 2024/03/01
- Product number
- P6902
- Product name
- Pheniramine maleate salt
- Packaging
- 5g
- Price
- $162
- Updated
- 2024/03/01
- Product number
- 1522301
- Product name
- Pheniramine maleate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 150mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- P2271
- Product name
- Pheniramine Maleate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $139
- Updated
- 2024/03/01
- Product number
- P0850000
- Product name
- Pheniramine maleate
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- p0850000
- Price
- $153
- Updated
- 2024/03/01
Pheniramine maleate Chemical Properties,Usage,Production
Chemical Properties
white powder
Originator
Trimeton Maleate, Schering ,US,1948
Uses
Pheniramine, a H1-receptor antagonist, is an antihistamine with anticholinergic and sedative properties. Pheniramine is used to treat allergic conditions such as hay fever or urticaria.
Uses
Antihistaminic;H1 antagonist
Uses
A H1 histamine receptor antagonist.
Uses
Used medicinally as an antihistaminic (merck).
Definition
ChEBI: Pheniramine maleate is an organic molecular entity.
Manufacturing Process
According to US Patent 2,676,964: to 1.0 mol of potassium amide in 3 liters of liquid ammonia, is added 1.0 mol of 2-benzylpyridine. After 15 minutes, 1.1 mols of β-dimethylaminoethyl chloride are added. The ammonia is allowed to evaporate and the reaction product decomposed with water and ether extracted. The ether layer is dried over sodium sulfate and after evaporation the residue is distilled, giving the 3-phenyl-3-(2-pyridyl)-N,Ndimethylpropylamine, BP 139°-142°C/1-2 mm. The maleate is produced by reaction with maleic acid.
Therapeutic Function
Antihistaminic
General Description
Pheniramine maleate, 2-[α-[2-dimethylaminoethyl]benzyl]-pyridine bimaleate (Trimeton,Inhiston), is a white crystalline powder, with a faint aminelikeodor, which is soluble in water (1:5) and very soluble inalcohol. This drug is the least potent member of the seriesand is marketed as the racemate. The usual adult dose is 20to 40 mg 3 times daily. It is available in certain combinationproducts.
General Description
White powder with a faint amine-like odor. Melting point 107°C. pH (1% solution) 4.5-5.5. Used medicinally as an antihistaminic.
Air & Water Reactions
Water soluble.
Reactivity Profile
Pheniramine maleate gives weakly acidic aqueous solutions. May react with strong oxidizing agents.
Fire Hazard
Flash point data are not available for Pheniramine maleate, but Pheniramine maleate is probably combustible.
Biochem/physiol Actions
Pheniramine maleate is a H1 histamine receptor antagonist. It is an alkylamine derivative. Structurally, pheniramine contains a chiral carbon atom with a hydrogen atom. Other substituents include the pyridyl, alkylamine and phenyl groups. It is used as an antiallergic drug for treating the common cold, respiratory allergies, urticaria, and systematic allergic reactions.
Pheniramine maleate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Pheniramine maleate manufacturers
- Product
- Pheniramine maleate 132-20-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2023-03-09
- Product
- Pheniramine maleate 132-20-7
- Price
- US $1.00-1.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-05-08
- Product
- Pheniramine maleate 132-20-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 100KG
- Release date
- 2021-06-18