3-Amino-3-(3-fluorophenyl)propanoic acid
- Product Name
- 3-Amino-3-(3-fluorophenyl)propanoic acid
- CAS No.
- 117391-51-2
- Chemical Name
- 3-Amino-3-(3-fluorophenyl)propanoic acid
- Synonyms
- VITAS-BB TBB000014;BIO-FARMA BF000152;RARECHEM AK HC T308;3-FLUOROPHENYL-BETA-DL-ALANINE;3-(3-FLUOROPHENYL)-BETA-ALANINE;DL-BETA-(3-FLUORO-PHENYL)ALANINE;3-(3-fluoro-phenyl)-DL-beta-alanine;3-AMINO-3-(3-FLUOROPHENYL)PROPANOIC ACID;Benzenepropanoic acid, β-amino-3-fluoro-;3-AMINO-3-(3-FLUORO-PHENYL)-PROPIONIC ACID
- CBNumber
- CB9400544
- Molecular Formula
- C9H10FNO2
- Formula Weight
- 183.18
- MOL File
- 117391-51-2.mol
3-Amino-3-(3-fluorophenyl)propanoic acid Property
- Melting point:
- 210-212°C
- Boiling point:
- 305.7±32.0 °C(Predicted)
- Density
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 3.61±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 117391-51-2(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36/37/39
- HazardClass
- IRRITANT
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A634690
- Product name
- 3-Amino-3-(3-fluorophenyl)propanoicAcid
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 038690
- Product name
- 3-Amino-3-(3-fluorophenyl)propanoic acid
- Packaging
- 500mg
- Price
- $189
- Updated
- 2021/12/16
- Product number
- PC10275
- Product name
- 3-Amino-3-(3-fluorophenyl)propanoic acid
- Packaging
- 1g
- Price
- $27
- Updated
- 2021/12/16
- Product number
- 4657-3-X1
- Product name
- 3-Amino-3-(3-fluorophenyl)propanoic acid
- Packaging
- 1g
- Price
- $32
- Updated
- 2021/12/16
- Product number
- X9206
- Product name
- 3-Amino-3-(3-fluorophenyl)propanoicacid
- Packaging
- 25g
- Price
- $276
- Updated
- 2021/12/16
3-Amino-3-(3-fluorophenyl)propanoic acid Chemical Properties,Usage,Production
Uses
3-Amino-3-(3-fluorophenyl)propanoic Acid is a useful research intermediate for organic synthesis.
Synthesis
141-82-2
456-48-4
117391-51-2
To 5.00 g (40.3 mmol) of 3-fluorobenzaldehyde was added 20 mL of ethanol followed by 4.19 g (40.3 mmol) of malonic acid and 4.66 g (60.4 mmol) of ammonium acetate. The mixture was heated to 80 to 90°C with stirring and the reaction was refluxed for 7 hours. Upon completion of the reaction, the reaction mixture was cooled to 0 to 5°C and stirring was continued for 1 h. Subsequent filtration afforded 4.27 g of 3-amino-3-(3-fluorophenyl)propionic acid (racemic mixture) as a white powder (57.9% isolated yield based on 3-fluorobenzaldehyde). The physical properties of 3-amino-3-(3-fluorophenyl)propionic acid (racemic mixture) were as follows: 1H-NMR (δ (ppm), D2O): 2.83 (dd, 1H, J = 16.1, 6.8 Hz), 2.90 (dd, 1H, J = 16.1, 7.8 Hz), 4.67 (dd, 1H, J = 6.8, 7.8 Hz), 7.2-7.5 (m, 5H). 13C-NMR (δ (ppm), D2O): 43.4, 55.1, 116.9, 119.0, 125.7, 134.0, 141.5, 164.3, 179.9. MS (EI) m/z: 183 (M+). MS (CI, i-C4H10) m/z: 184 (MH+).
References
[1] Journal of Organic Chemistry, 2009, vol. 74, # 23, p. 9152 - 9157
[2] Advanced Synthesis and Catalysis, 2017, vol. 359, # 9, p. 1570 - 1576
[3] Patent: EP1621529, 2006, A1. Location in patent: Page/Page column 37-38
[4] Tetrahedron Asymmetry, 2008, vol. 19, # 17, p. 2072 - 2077
[5] Advanced Synthesis and Catalysis, 2010, vol. 352, # 2-3, p. 395 - 406
3-Amino-3-(3-fluorophenyl)propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Amino-3-(3-fluorophenyl)propanoic acid manufacturers
- Product
- 3-Amino-3-(3-fluorophenyl)propanoic acid 117391-51-2
- Price
- US $1.10-9.90/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 100KG
- Release date
- 2025-08-20
- Product
- 3-Amino-3-(3-fluorophenyl)propanoic acid 117391-51-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2019-12-26