BOC-L-3-FLUOROPHENYLALANINE

Product Name: BOC-L-3-FLUOROPHENYLALANINE
CAS No.: 114873-01-7
Chemical Name: BOC-L-3-FLUOROPHENYLALANINE
Synonyms: Boc-L-3-F-Phe;BOC-PHE(3-F)-OH;BOC-PHE(M-F)-OH;BOC-L-PHE(3-F)-OH;BOC-L-3-FLUOROPHE;BOC-3-FLUORO-L-PHE;RARECHEM BK PT 0026;BOC-M-FLUORO-PHE-OH;Boc-m-fluoro-L-Phe-OH;BOC-L-3-FLUOROPHENYLALA
CBNumber: CB2141299
Molecular Formula: C14H18FNO4
Formula Weight: 283.3
MOL File: 114873-01-7.mol

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BOC-L-3-FLUOROPHENYLALANINE Property

Melting point:: 75-80 °C
Boiling point:: 425.0±40.0 °C(Predicted)
Density: 1.1918 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: slightly sol. in Ethanol
form: powder to crystal
pka: 3.82±0.10(Predicted)
color: White to Almost white
optical activity: [α]20/D +6.5±1°, c = 1% in methanol
BRN: 5347375
InChI: InChI=1S/C14H18FNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-5-4-6-10(15)7-9/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1
InChIKey: FPCCREICRYPTTL-NSHDSACASA-N
SMILES: C(O)(=O)[C@H](CC1=CC=CC(F)=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference: 114873-01-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HazardClass: IRRITANT
HS Code: 2922498590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B4367
Product name: N-(tert-Butoxycarbonyl)-3-fluoro-L-phenylalanine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: B4367
Product name: N-(tert-Butoxycarbonyl)-3-fluoro-L-phenylalanine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $135
Updated: 2025/07/31

Usbiological

Product number: 264944
Product name: Boc-3-fluoro-L-phenylalanine
Packaging: 2g
Price: $353
Updated: 2021/12/16

Usbiological

Product number: 235922
Product name: Boc-3-fluoro-L-phenylalanine 99+%
Packaging: 1g
Price: $170
Updated: 2021/12/16

TRC

Product number: B435450
Product name: 3-Fluorophenyl-2-tert-butyloxycarbonylaminopropionicAcid
Packaging: 2.5g
Price: $130
Updated: 2021/12/16

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BOC-L-3-FLUOROPHENYLALANINE Chemical Properties,Usage,Production

Chemical Properties

off-white crystalline powder

Uses

peptide synthesis

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

19883-77-3

114873-01-7

The general procedure for the synthesis of (S)-2-((tert-butoxycarbonyl)amino)-3-(3-fluorophenyl)propionic acid from di-tert-butyl dicarbonate and L-3-fluorophenylalanine was as follows: first, L-2-amino-3-(3-fluorophenyl)-propionic acid (20.0 g, 110 mmol, 1 eq.) was dissolved in water (100 mL) and sodium carbonate (16.2 g. 153 mmol, 1.4 eq.) in water (40 mL). Subsequently, 1,4-dioxane (100 mL) was added and the mixture was cooled to 0 °C. Di-tert-butyl dicarbonate was added with stirring and the reaction mixture was then stirred at room temperature for 5 hours. After the reaction was complete, the dioxane was removed by evaporation. Water (125 mL) was added to dilute the reaction mixture, which was subsequently washed with ether (2 x 100 mL). The aqueous phase was acidified with 10% citric acid and then extracted with ethyl acetate (2 x 300 mL). The organic phases were combined, washed sequentially with water (2×150 mL) and brine (150 mL), dried with anhydrous sodium sulfate, and concentrated to afford the target product (S)-2-((tert-butoxycarbonyl)amino)-3-(3-fluorophenyl)propionic acid as a colorless viscous oil, which slowly solidified after standing (31 g, quantitative yield). The 1H NMR (CDCl3) data of the product were as follows: δ 7.33-7.26 (m, 1H), 7.00-6.91 (m, 3H), 4.96 (s, 1H), 4.62 (bs, 1H), 3.23 (dd, J = 14, 5.3Hz, 2H), 1.44 (s, 9H). Elemental analysis (C14H18NO4F) calculated values: C, 59.36; H, 6.40; N, 4.94. measured values: C, 59.29; H, 6.34; N, 4.90.

References

[1] Patent: WO2005/26114, 2005, A1. Location in patent: Page/Page column 85
[2] Patent: WO2005/26114, 2005, A1. Location in patent: Page/Page column 102
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 2090 - 2099

BOC-L-3-FLUOROPHENYLALANINE Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-L-3-FLUOROPHENYLALANINE Suppliers

Americas 1 Belgium 1 China 146 Europe 2 France 1 Germany 5 India 6 Japan 3 South Korea 1 Switzerland 3 United Kingdom 9 United States 47 Global 225

Shanghai Jifeng Biotechnology Co., Ltd.

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Energy Chemical

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Suzhou haiyu Biochem Industrial Co., LTD

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Pure Chemistry Scientific Inc.

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View Lastest Price from BOC-L-3-FLUOROPHENYLALANINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: BOC-L-3-FLUOROPHENYLALANINE 114873-01-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-08

Career Henan Chemical Co

Product: BOC-L-3-FLUOROPHENYLALANINE 114873-01-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 351
Release date: 2019-09-01

114873-01-7, BOC-L-3-FLUOROPHENYLALANINERelated Search:

RARECHEM BK PT 0026

(S)-2-TERT-BUTOXYCARBONYLAMINO-3-(3-FLUORO-PHENYL)-PROPIONIC ACID

(S)-N-BOC-3-FLUOROPHENYLALANINE

N-TERT-BUTOXYCARBONYL-3-FLUOROPHENYL-L-ALANINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-3-FLUORO-L-PHENYLALANINE

N-ALPHA-T-BUTYLOXYCARBONYL-L-3-FLUOROPHENYLALANINE

N-ALPHA-T-BUTOXYCARBONYL-3-FLUORO-L-PHENYLALANINE

L-3-FLUOROPHENYLALANINE, BOC PROTECTED

BOC-(S)-2-AMINO-3-(3'-FLUOROPHENYL)PROPANOIC ACID

BOC-PHE(M-F)-OH

BOC-PHE(3-F)-OH

BOC-3-FLUORO-L-PHE

BOC-3-FLUORO-L-PHENYALANINE

BOC-3-FLUORO-L-PHENYLALANINE

BOC-L-PHE(3-F)-OH

(S)-2-((tert-butoxycarbonyl)(3-fluorophenyl)amino)propanoic acid

(S)-Boc-3-fluoro-phenylalanine

(S)-2-Boc-amino-3-(3-fluorophenyl)propionic acid

Boc-3-fluoro-L-phenylalanine99%

Boc-m-fluoro-L-Phe-OH

(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3-fluorophenyl)propionic acid

BOC-L-3-FLUOROPHENYLALA

(Tert-Butoxy)Carbonyl Phe(3-F)-OH

Boc-Phe(3-F)-OH, ≥98.0%

tert-Butoxycarbonyl-L-3-fluorophenylalanine

Boc-L-3-F-Phe

BOC-O-FLUORO-L-PHENYALANINE

BOC-M-FLUORO-PHE-OH

BOC-L-3-FLUOROPHE

BOC-L-3-FLUOROPHENYLALANINE

L-3-Fluorophenylalanine, N-BOC protected

N-alpha-tert-Butoxycarbonyl-3-(3-fluorophenyl)-L-al

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-3-FLUOROPHENYLALANINE

N-tert-Butoxycarbonyl-L-3-Fluoro Phenylalanine

3-Fluoro-L-phenylalanine,N-BOCprotected

(S)-N-BOC-3-FLUOROPHENYLALANINE 98+%

N-alpha-t-Butyloxycarbonyl-3-fluoro-L-phenylalanine

Boc-2-fluoro-L-phenyalanine

(S)-N-BOC-3-FLUOROPHENYLALANINE, 95%, 98% EE

(S)-N-BOC-3-Fluorophenylalanine, 98% ee

(S)-2-[(tert-Butoxycarbonyl)amino]-3-(3-fluorophenyl)propanoic acid

C-L-3-FLUOROPHENYLALANINE

(S)-N-(tert-Butoxycarbonyl)-3-fluorophenylalanine, Tech.

L-Phenylalanine,N-[(1,1-diMethylethoxy)carbonyl]-3-fluoro-

N-Boc-3-fluoro-L-phenylalanine, 95%

Boc-L-Phe(3-F) -OH Boc-3-Fluoro-L-Phenylalanine

Boc-3-fluoro-L-phenylalanine Boc-M-fluoro-Phe-OH

(2S)-2-[(tert-Butoxycarbonyl)amino]-3-(3-fluorophenyl)propanoic acid, N-(tert-Butoxycarbonyl)-3-fluoro-L-phenylalanine

Boc-Phe(3-F)-OH >=98.0% (TLC)

N-(tert-Butoxycarbonyl)-3-fluoro-L-phenylalanine

(2S)-3-(3-fluorophenyl)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]propanoate

N-(tert-Butoxycarbonyl)-3-fluoro-L-phenylalanine &gt

BOC-L-3-FLUOROPHENYLALANINE USP/EP/BP

3-Fluorophenyl-2-tert-butyloxycarbonylaminopropionic Acid

Boc-L-3-Fluorophe 114873-01-7

(2S)-3-(3-fluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

N-[(1,1-Dimethylethoxy)carbonyl]-3-fluoro-L-phenylalanine

Venadaparib Impurity 69