BOC-L-2-Fluorophe
- Product Name
- BOC-L-2-Fluorophe
- CAS No.
- 114873-00-6
- Chemical Name
- BOC-L-2-Fluorophe
- Synonyms
- BOC-PHE(2-F)-OH;BOC-PHE(O-F)-OH;BOC-L-2-FLUOROPHE;BOC-L-PHE(2-F)-OH;BOC-2-FLUORO-L-PHE;RARECHEM BK PT 0020;BOC-O-FLUORO-PHE-OH;(S)-BOC-2-Fluorophe;Boc-o-fluoro-L-Phe-OH;Boc-L-2-Fluoro-phe-OH
- CBNumber
- CB5745883
- Molecular Formula
- C14H18FNO4
- Formula Weight
- 283.3
- MOL File
- 114873-00-6.mol
BOC-L-2-Fluorophe Property
- Melting point:
- 92-96 °C
- alpha
- 10 º (c=1,EtOAc)
- Boiling point:
- 427.3±40.0 °C(Predicted)
- Density
- 1.1918 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Powder
- pka
- 3.87±0.11(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- [α]20/D +9±1°, c = 1% in ethyl acetate
- BRN
- 5347990
- CAS DataBase Reference
- 114873-00-6(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 235857
- Product name
- Boc-2-fluoro-L-phenylalanine 99+%
- Packaging
- 1g
- Price
- $170
- Updated
- 2021/12/16
- Product number
- 008082
- Product name
- BOC-l-2-Fluorophenylalanine
- Purity
- 99%
- Packaging
- 250mg
- Price
- $14
- Updated
- 2021/12/16
- Product number
- 04136
- Product name
- Boc-2-fluoro-L-phenylalanine
- Purity
- ≥ 99% (HPLC)
- Packaging
- 1G
- Price
- $20
- Updated
- 2021/12/16
- Product number
- 089316
- Product name
- Boc-2-fluoro-L-phenylalanine
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- AS87914
- Product name
- Boc-2-Fluoro-L-phenylalanine
- Purity
- 95+% ee
- Packaging
- 1g
- Price
- $57
- Updated
- 2021/12/16
BOC-L-2-Fluorophe Chemical Properties,Usage,Production
Chemical Properties
white to light yellow crystal powde
Uses
peptide synthesis
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
24424-99-5
19883-78-4
114873-00-6
General steps: 1. 2-Fluoro-L-phenylalanine (1.00 g) was dissolved in a mixture of dioxane (10 ml) and water (5 ml) under cooling conditions in an ice bath. 2. 1N aqueous sodium hydroxide solution (5.46 ml) and di-tert-butyl dicarbonate (1.38 ml) were slowly added to the above solution, keeping the reaction system in an ice bath. 3. The ice bath was removed and the reaction mixture was stirred at room temperature for 1 hour. 4. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure to remove the organic solvent. 5. The pH of the concentrate was adjusted to 2.5 with dilute hydrochloric acid. 6. 6. The aqueous phase was extracted with ethyl acetate (100 ml x 3) and the organic phases were combined. 7. Wash the organic phase with water and saturated saline in turn. 8. 8. Dry the organic phase with anhydrous sodium sulfate and filter to remove the desiccant. 9. The filtrate was concentrated under pressure to obtain the crude product. 10. The crude product was recrystallized with ethyl acetate-petroleum ether mixed solvent to obtain N-Boc-2-fluoro-L-phenylalanine (1.32 g, 85% yield) as colorless crystals.
References
[1] Patent: US5556853, 1996, A
[2] Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 2090 - 2099
BOC-L-2-Fluorophe Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from BOC-L-2-Fluorophe manufacturers
- Product
- Boc-Phe(2-F)-OH 114873-00-6
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-09-08
- Product
- BOC-L-2-Fluorophe 114873-00-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-08
- Product
- BOC-L-2-Fluorophe 114873-00-6
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 379
- Release date
- 2019-09-01