BOC-L-4-Fluorophe

Product Name: BOC-L-4-Fluorophe
CAS No.: 41153-30-4
Chemical Name: BOC-L-4-Fluorophe
Synonyms: Boc-L-4-F-Phe;BOC-P-F-PHE-OH;BOC-L-PHE(4-F);BOC-PHE(P-F)-OH;BOC-PHE(4-F)-OH;Boc-L-4-flourophe;BOC-L-PHE(4-F)-OH;BOC-L-4-FLUOROPHE;BOC-4-FLUORO-L-PHE;RARECHEM BK PT 0032
CBNumber: CB6116369
Molecular Formula: C14H18FNO4
Formula Weight: 283.3
MOL File: 41153-30-4.mol

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BOC-L-4-Fluorophe Property

Melting point:: 83-86 °C
alpha: 8 º (c=1,MeOH)
Boiling point:: 431.2±40.0 °C(Predicted)
Density: 1.1918 (estimate)
storage temp.: Sealed in dry,2-8°C
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 3.87±0.10(Predicted)
color: White
optical activity: 8.8°(C=1.00g/100ml MEOH)
BRN: 4323475
InChI: InChI=1S/C14H18FNO4/c1-14(2,3)20-13(19)16-11(12(17)18)8-9-4-6-10(15)7-5-9/h4-7,11H,8H2,1-3H3,(H,16,19)(H,17,18)/t11-/m0/s1
InChIKey: RCXSXRAUMLKRRL-NSHDSACASA-N
SMILES: C(O)(=O)[C@H](CC1=CC=C(F)C=C1)NC(OC(C)(C)C)=O
CAS DataBase Reference: 41153-30-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
HS Code: 29242990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 15352
Product name: Boc-Phe(4-F)-OH
Purity: ≥99.0% (TLC)
Packaging: 1g
Price: $191
Updated: 2023/06/20

Sigma-Aldrich

Product number: 15352
Product name: Boc-Phe(4-F)-OH
Purity: ≥99.0% (TLC)
Packaging: 5g
Price: $316
Updated: 2023/06/20

TCI Chemical

Product number: B3304
Product name: N-(tert-Butoxycarbonyl)-4-fluoro-L-phenylalanine
Purity: >98.0%(T)
Packaging: 1g
Price: $65
Updated: 2025/07/31

TCI Chemical

Product number: B3304
Product name: N-(tert-Butoxycarbonyl)-4-fluoro-L-phenylalanine
Purity: >98.0%(T)
Packaging: 5g
Price: $259
Updated: 2025/07/31

Frontier Specialty Chemicals

Product number: JK120726
Product name: Boc-L-4-flourophenylalanine
Purity: 99%
Packaging: 5g
Price: $429
Updated: 2021/12/16

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BOC-L-4-Fluorophe Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powde

Uses

Boc-Phe(4-F)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

24424-99-5

1132-68-9

41153-30-4

General procedure for the synthesis of Boc-L-4-fluorophenylalanine from di-tert-butyl dicarbonate and (S)-2-amino-3-(4-fluorophenyl)propionic acid: (S)-2-amino-3-(4-fluorophenyl)propionic acid (1.97 g, 10 mmol) was dissolved in a mixture of dioxane (20 mL), water (20 mL), and 1 M NaOH (10 mL), stirred and cooled in an ice water bath. Di-tert-butyl dicarbonate (2.4 g, 11 mmol) was added slowly and the reaction mixture was continued to be stirred for 6 hours at room temperature. Upon completion of the reaction, the solution was concentrated under reduced pressure to about 15-20 mL and then cooled in an ice water bath. The concentrate was covered with ethyl acetate (~30 mL) and acidified to pH 2-3 with the addition of dilute KHSO4 solution. the aqueous phase was separated and extracted three times with ethyl acetate. The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give a waxy solid product. Yield: 2.115 g (7.25 mmol, 72.5% yield). The product was characterized by 1H NMR and MALDI-TOF mass spectrometry: 1H NMR (DMSO-d6, 400 MHz, ppm): δ 12.60 (s, 1H, COOH), 7.29-7.25 and 7.11-7.07 (m, 4H, aromatic protons), 4.10-3.00 (m, 1H, CH), 3.03-2.77 ( m, 2H, CH2), 1.33 (s, 9H, Boc). MALDI-TOF (Substrate: α-cyano-4-hydroxycinnamic acid (CHCA)): m/z = [M + H]+ 284.12 (calculated), 284.29 (observed), [M + Na]+ 306.11 (calculated), 306.25 (observed).

References

[1] Chemical Communications, 2014, vol. 50, # 76, p. 11154 - 11157
[2] Patent: WO2017/42805, 2017, A1. Location in patent: Page/Page column 24; 25
[3] Journal of Medicinal Chemistry, 1994, vol. 37, # 13, p. 2090 - 2099
[4] Bioorganic and Medicinal Chemistry, 1996, vol. 4, # 10, p. 1733 - 1745

BOC-L-4-Fluorophe Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-L-4-Fluorophe Suppliers

Americas 1 Belgium 1 China 168 Europe 3 France 1 Germany 6 India 2 Japan 4 South Korea 1 Switzerland 2 United Kingdom 11 United States 48 Global 248

Wuhan Shenxinda Chemical Technology Co., Ltd.

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Energy Chemical

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GL Biochem (Shanghai) Ltd

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View Lastest Price from BOC-L-4-Fluorophe manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: Boc-L-4-Fluorophenylalanine 41153-30-4
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 100kg
Release date: 2025-09-08

Career Henan Chemical Co

Product: BOC-L-4-Fluorophe 41153-30-4
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 411
Release date: 2019-09-01

41153-30-4, BOC-L-4-Fluorophe Related Search:

N-(tert-Butoxycarbonyl)-L-phenylalanine N-Carbobenzyloxyglycine EC 2.6.1.2 tert-Butanol D-Phenylalanine DL-Phenylalanine Phenprobamate Boc-Aib-OH D-Alanine BOC-L-3,4-Difluorophe BOC-D-3-FLUOROPHE BOC-L-2-FLUOROPHE BOC-L-4-Methylphe L-Phenylalanine BOC-GLY-LEU-OH BOC-L-PENTAFLUOROPHENYLALANINE (S)-N-Boc-(4-Pyridyl)alanine BOC-L-4-Chlorophe

N-alpha-t-Butyloxycarbonyl-4-fluoro-L-phenylalanine

(S)-N-BOC-4-FLUOROPHENYLALANINE, 95%, 98% EE

(S)-N-BOC-4-Fluorophenylalanine, 98% ee

Boc-L-4-Fluoro-phe-OH

N-(tert-Butoxycarbonyl)-4-fluoro-L-phenylalanine

L-Phenylalanine,N-[(1,1-diMethylethoxy)carbonyl]-4-fluoro-

Boc-L-Phe(4-F) -OH Boc-4-Fluoro-L-Phenylalanine

N-Boc-4-fluoro-L-phenylalanine Boc-Phe(4-F)-OH

Boc-4-fluoro-L-phenylalanine Boc-p-fluoro-Phe-OH

N-(tert-butoxycarbonyl)-p-fluoro-L-phenylalanine

N-Boc-4-fluoro-L-phenylalanine, 95%

Boc-L-4-flourophenylalanine

Boc-L-4-flourophe

Boc-Phe(4-F)-OH >=99.0% (TLC)

(S)-2-((tert-butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoic acid

(Tert-Butoxy)Carbonyl Phe(4-F)-OH

(2S)-3-(4-fluorophenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid

BOC-P-F-PHE-OH

(S)-Boc-2-amino-3-(4-fluorophenyl)propionic acid

Boc-4-fluoro-L-phenylalanine≥ 99% (HPLC)

Boc-p-fluoro-L-Phe-OH

N-Boc-4-fluoro-L-phenylalanine,99%e.e.

N-ALPHA-T-BOC-4-FLUORO-L-PHENYLALANINE

N-ALPHA-T-BUTOXYCARBONYL-(4-FLUORO)-L-PHENYLALANINE

N-ALPHA-T-BUTYLOXYCARBONYL-L-4-FLUOROPHENYLALANINE

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-4-FLUOROPHENYLALANINE

RARECHEM BK PT 0032

tert-butoxycarbonyl-l-4-fluorophenylalanine

(S)-N-BOC-4-FLUOROPHENYLALANINE

(S)-2-TERT-BUTOXYCARBONYLAMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID

BOC-(S)-2-AMINO-3-(4'-FLUOROPHENYL)PROPANOIC ACID

BOC-L-PHE(4-F)

BOC-L-PHE(4-F)-OH

BOC-P-FLUORO-L-PHENYLALANINE

BOC-P-FLUORO-PHENYLALANINE

BOC-P-FLUORO-PHE-OH

BOC-PHE(P-F)-OH

BOC-PHE(4-F)-OH

BOC-4-FLUORO PHENYLALANINE

BOC-4-FLUORO-PHE-OH

BOC-4-FLUORO-L-PHE

BOC-4-FLUORO-L-PHENYLALANINE

BOC-L-4-FLUOROPHE

BOC-L-4-FLUOROPHENYLALANINE

N-TERT-BUTOXYCARBONYL-4-FLUOROPHENYL-L-ALANINE

L-4-FLUOROPHENYLALANINE, BOC PROTECTED

Boc-4-Fluoro-L-Phe-OH

N-alpha-tert-Butoxycarbonyl-3-(4-fluorophenyl)-L-al

BOC-L-4-FLUOROPHENYLALANINE,98%

4-Fluoro-L-phenylalanine,N-BOCprotected

1-diMethylethoxy)carbonyl]-4-fluoro-

Boc-L-4-F-Phe

2-[(4-fluorophenyl)methyl]-3-[(2-methylpropan-2-yl)oxy]-3-oxopropanoic acid

N-(tert-Butoxycarbonyl)-4-fluoro-L-phenylalanine&gt

BOC-L-4-Fluorophe USP/EP/BP

Venadaparib Impurity 67

(S)-2-((tert-Butoxycarbonyl)amino)-3-(4-fluorophenyl)propanoic acid - [B91613]

N-Boc-4-fluoro-L-phenylalanine