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Solvent Green 7

Product Name
Solvent Green 7
CAS No.
6358-69-6
Chemical Name
Solvent Green 7
Synonyms
HPTS;CI 59040;PYRANINE;8-Hydroxypyrene-1,3,6-trisulfonic acid;MIDORI204;8-hydroxypyrene-1,3,6-trisulfonate;Trisodium 8-hydroxypyrene-1,3,6-trisulphonate;1,3,6-Pyrenetrisulfonicacid,8-hydroxy-,trisodiumsalt;GREEN 8;Pyranin
CBNumber
CB9402700
Molecular Formula
C16H7Na3O10S3
Formula Weight
524.39
MOL File
6358-69-6.mol
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Solvent Green 7 Property

Melting point:
62-63.5 °C(lit.)
Boiling point:
171-178 °C10 mm Hg(lit.)
Density 
2.15
vapor pressure 
0Pa at 25℃
Flash point:
250 °C
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
methanol: 0.1 g/mL, clear
Colour Index 
59040
form 
Powder
pka
7.3, (at 22℃)
color 
yellow
Water Solubility 
300 g/L (25 ºC)
λmax
403 nm (Buffer pH 4.0); 454 nm (Buffer pH 9.0)
Merck 
7954
BRN 
4107272
Major Application
Adhesives; agrochemicals; ammonia sensor; carbon dioxide sensor; oxygen sensor; anionic surfactants sensor; measuring the size of the organoclay aggregates; detecting cracks/flaws in metallic surfaces, refrigerant leaking; detergents; correction fluid; highlighters; inks; markers; paints; pencils; toners; chemically amplified resist; color filters; chemiluminescent materials; electrophoretic display (EPD) film materials; electroluminescent displays/materials; fuel cell; lasers; liquid crystal displays; luminescent materials; nanoparticles; papers; photoresist processes; photonic ionic liquids; soils; solar cell; sol–gel materials/processes/thin films; sonophotoluminescence; water tracers; evaluating liquid water flow in wood during drying
Biological Applications
Antiperspirants; bath preparations; cleansing products; cosmetics; contact lens; hair dyes; hygiene products/soaps; food products; controlled-release system for proteins; drug delivery; in ophthalmology/retinal surgery; sugar sensors (glucose, fructose, lactose, sucrose); as a substrate for measuring acetylcholinesterase (AChE) activity, carbonic anhydrase activity, esterases activity, β-glucuronidase activity, lipase activity, acidic/alkaline phosphatases activity, pyrophosphatase activity, sucrose phosphorylase (SPO) activity, phosphoglucomutase (PGM) activity; treating cancer, infection, immune/autoimmune disease, mastitis, tonsillitis, tuberculosis
LogP
-3.97 at 25℃
CAS DataBase Reference
6358-69-6(CAS DataBase Reference)
EPA Substance Registry System
C.I. Solvent Green 7 (6358-69-6)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38
Safety Statements 
36/37-37/39-26-36
WGK Germany 
3
RTECS 
UR2700000
TSCA 
Yes
HS Code 
29089990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H1529
Product name
8-Hydroxypyrene-1,3,6-trisulfonic acid trisodium salt
Purity
≥96%
Packaging
1g
Price
$103
Updated
2024/03/01
Sigma-Aldrich
Product number
16214
Product name
Solvent Green 7 hydrate
Purity
analytical standard
Packaging
100mg
Price
$74.8
Updated
2021/12/16
Alfa Aesar
Product number
L11252
Product name
Pyranine
Packaging
5g
Price
$61.1
Updated
2024/03/01
Alfa Aesar
Product number
L11252
Product name
Pyranine
Packaging
25g
Price
$211
Updated
2024/03/01
Cayman Chemical
Product number
30080
Product name
8-Hydroxypyrene-1,3,6-trisulfonic Acid (sodium salt)
Packaging
500mg
Price
$59
Updated
2024/03/01
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Solvent Green 7 Chemical Properties,Usage,Production

Chemical Properties

yellow to green-yellow powder

Uses

Pyranine is used as a fluorescent pH indicator with emission change in the physiological pH range. It acts as a dye in optical sensor applications. It finds application as a coloring agent and biological stain. It is also used in the measurement of pH of intracellular fluid in the cells.

Definition

ChEBI: Pyranine is an organic sodium salt. It has a role as a fluorochrome. It contains a pyranine(3-). It derives from a hydride of a pyrene.

Preparation

commonly known as Pyranine. Pyrene-1,3,6,8-tetrasulfonic acid?and 15 ~ 20% sodium hydroxide reflux, also can use ammonia water on hydrolysis reaction, this condition the product contains APTS(8-Aminopyrene-1,3,6-trisulfonic acid?).

Flammability and Explosibility

Not classified

Biological Activity

Pyranine (HPTS; Solvent Green 7) is a pH-sensitive fluorescent indicator. Pyranine is a class of fluorescent chemosensors for Cu+ ions (λex=450 nm, λem=510 nm).

in vitro

Pyranine is capable of discriminating ranges of cations from the Cu + ion, even in competing environment. Pyranine displays a rapid fluorescence response (t 1/2 =1.66 min) towards the Cu + ion, and the micromolar detection limit enables the detection of the ion in environmental samples. The observed stoichiometry of complexation between Pyranine and Cu + is 2:1.The pH-sensitive fluorescent indicator Pyranine is studied to determine its usefulness as probes for the living cornea and anterior chamber. Adequate concentrations are reached in the cornea and anterior chamber after topical administration; measurements can be made by fluorophotometry for many hours. The pH is calculated by measuring the ratio of fluorescent intensity at two excitation wavelengths, I463/I404, a measurement which is dependent on pH but independent of the concentration of the fluorophore and other variables which can alter the intensity. In the rabbit eye, Pyranine in the cornea and anterior chamber is observed to undergo easily measurable changes in fluorescent ratios associated with lid closure and contact lens wear, indicating its sensitivity to mild changes in pH.

Properties and Applications

yellow green. Slightly soluble in glacial acetic acid, 30% hydrochloric acid, insoluble in acetic acid and 10% hydrochloric acid. Mainly used in medicine and cosmetics coloring.

Standard Light Fastness Heat-resistant(℃) water Sodium Carbonate(5%) Hydrochloric acid(5%)
Melting point Stable
ISO Dissole

Purification Methods

Purify the salt by chromatography with an alumina column, and elute with n-propanol/water (3:1, v/v). Recrystallise it from aqueous acetone (5:95, v/v) using decolorising charcoal. [Beilstein 1 III 565.] IRRITANT.

Solvent Green 7 Preparation Products And Raw materials

Raw materials

Preparation Products

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Solvent Green 7 Suppliers

Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223
Email
psaitong@jm-bio.com
Country
China
ProdList
29834
Advantage
58
Hubei Enxing Biotechnology Co., Ltd
Tel
16621771607
Email
exbio_tech@163.com
Country
China
ProdList
8362
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7583
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12426
Advantage
60
RYSS TECH LTD
Tel
400-188-0725 +86 21 34310725 13611771617
Fax
+86 21 34311076
Country
China
ProdList
2002
Advantage
57
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View Lastest Price from Solvent Green 7 manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Solvent Green 7 6358-69-6
Price
US $20.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-28
Wuhan wingroup Pharmaceutical Co., Ltd
Product
Solvent Green 7 6358-69-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-07-13
Zhuozhou Wenxi import and Export Co., Ltd
Product
Solvent Green 7 6358-69-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

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