5-CHLOROQUINOLINE
- Product Name
- 5-CHLOROQUINOLINE
- CAS No.
- 635-27-8
- Chemical Name
- 5-CHLOROQUINOLINE
- Synonyms
- 5-chloroquiboline;5-CHLOROQUINOLINE;Quinoline, 5-chloro-;5-Chloroquinoline >5-Chloroquinoline hydrochloride;5-CHLOROQUINOLINE ISO 9001：2015 REACH
- CBNumber
- CB9408025
- Molecular Formula
- C9H6ClN
- Formula Weight
- 163.6
- MOL File
- 635-27-8.mol
5-CHLOROQUINOLINE Property
- Melting point:
- 28-32 °C
- Boiling point:
- 263°C(lit.)
- Density
- 1.2108 (rough estimate)
- refractive index
- 1.6110 (estimate)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform, Ethyl Acetate, Methanol
- form
- Solid
- pka
- 3.88±0.12(Predicted)
- color
- Off-White to Yellow
- λmax
- 317nm(EtOH aq.)(lit.)
- BRN
- 114722
- InChI
- InChI=1S/C9H6ClN/c10-8-4-1-5-9-7(8)3-2-6-11-9/h1-6H
- InChIKey
- HJSRGOVAIOPERP-UHFFFAOYSA-N
- SMILES
- N1C2C(=C(Cl)C=CC=2)C=CC=1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C2997
- Product name
- 5-Chloroquinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $61
- Updated
- 2025/07/31
- Product number
- C2997
- Product name
- 5-Chloroquinoline
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $213
- Updated
- 2025/07/31
- Product number
- C379980
- Product name
- 5-Chloroquinoline
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- J95210
- Product name
- 5-Chloroquinoline
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- FC20383
- Product name
- 5-Chloroquinoline
- Packaging
- 100mg
- Price
- $100
- Updated
- 2021/12/16
5-CHLOROQUINOLINE Chemical Properties,Usage,Production
Chemical Properties
Yellow Solid
Uses
5-Chloroquinoline (cas# 635-27-8) is a compound useful in organic synthesis.
Synthesis
611-34-7
635-27-8
General procedure for the synthesis of 5-chloroquinoline from 5-aminoquinoline: 5-aminoquinoline (756 mg, 5.24 mmol) was suspended in an aqueous 2N HCl solution (31 mL) and cooled to 0°C. A solution of NaNO2 (470 mg, 6.80 mmol) in water (14 mL) was added slowly with stirring. The reaction mixture was kept stirred at 0 °C for 30 min. Subsequently, a concentrated hydrochloric acid solution of CuCl (644 mg, 6.51 mmol) was added and additional concentrated hydrochloric acid (16 mL) was added. The reaction mixture was gradually warmed to room temperature and stirring was continued for 24 hours. After the reaction was completed, saturated NaHCO3 solution was added slowly until no more gas was produced. The organic phase was extracted with dichloromethane (3 x 50 mL) and the combined organic layers were washed with brine and dried over anhydrous MgSO4. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: EtOAc/hexane=1:1) to afford the target product 5-chloroquinoline (579 mg, 68% yield).
References
[1] Bioorganic and medicinal chemistry, 2002, vol. 10, # 8, p. 2611 - 2623
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1472 - 1476
[3] Patent: WO2016/86200, 2016, A1. Location in patent: Page/Page column 235
5-CHLOROQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-CHLOROQUINOLINE Suppliers
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View Lastest Price from 5-CHLOROQUINOLINE manufacturers
- Product
- 5-CHLOROQUINOLINE 635-27-8
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-10-15
- Product
- 5-CHLOROQUINOLINE 635-27-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 150KG
- Release date
- 2019-07-01