5,7-Dichloro-8-hydroxyquinaldine
- Product Name
- 5,7-Dichloro-8-hydroxyquinaldine
- CAS No.
- 72-80-0
- Chemical Name
- 5,7-Dichloro-8-hydroxyquinaldine
- Synonyms
- Quesil;Siogen;Siogene;Siogeno;Siosept;Afungil;Intensol;Saprosan;Siogenal;Siogenon
- CBNumber
- CB4728346
- Molecular Formula
- C10H7Cl2NO
- Formula Weight
- 228.07
- MOL File
- 72-80-0.mol
5,7-Dichloro-8-hydroxyquinaldine Property
- Melting point:
- 108-112 °C (dec.)(lit.)
- Boiling point:
- 350.7±37.0 °C(Predicted)
- Density
- 1.3126 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO, Methaol (Slightly)
- form
- Solid
- pka
- 2.47±0.30(Predicted)
- color
- Dark Beige to Very Dark Beige
- Water Solubility
- Insoluble
- Merck
- 13,2209
- BRN
- 156683
- CAS DataBase Reference
- 72-80-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Chlorquinaldol(72-80-0)
Safety
- Hazard Codes
- Xn,T
- Risk Statements
- 22-36/37/38-23/24/25
- Safety Statements
- 26-36-36/37/39-45
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- RTECS
- VC5600000
- HS Code
- 2933998090
N-Bromosuccinimide Price
- Product number
- 130532
- Product name
- 5,7-Dichloro-8-hydroxy-2-methylquinoline
- Purity
- 98%
- Packaging
- 10g
- Price
- $62.2
- Updated
- 2024/03/01
- Product number
- 29396
- Product name
- Chlorquinaldol
- Packaging
- 10g
- Price
- $40
- Updated
- 2024/03/01
- Product number
- 29396
- Product name
- Chlorquinaldol
- Packaging
- 25g
- Price
- $94
- Updated
- 2024/03/01
- Product number
- 29396
- Product name
- Chlorquinaldol
- Packaging
- 50g
- Price
- $177
- Updated
- 2024/03/01
- Product number
- D436823
- Product name
- 5,7-Dichloro-8-hydroxy-2-methylquinoline
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
5,7-Dichloro-8-hydroxyquinaldine Chemical Properties,Usage,Production
Chemical Properties
yellowish to beige-brown powder
Originator
Sterosan ,Geigy ,US ,1954
Uses
Chlorquinaldol is a fungistat and antibacterial agent in topical pharmaceutical preparations (5,7-dichloro-2-methyl-8-quinolinol, Sterosan).
Uses
antiinfectant, antifungal
Uses
5,7-Dichloro-8-hydroxy-2-methylquinoline is an anti-infective agent.
Definition
ChEBI: A monohydroxyquinoline that is quinolin-8-ol which is substituted by a methyl group at position 2 and by chlorine at positions 5 and 7. An antifungal and antibacterial, it was formerly used for topical treatment of skin conditions and vaginal infections.
Manufacturing Process
11.1 parts of 8-hydroxy-quinaldine are dissolved in 140 parts of formic acid.
Chlorine is introduced into this solution under cooling, until the increase in
weight corresponds to the required quantity of chlorine and a test of the
chlorination mixtures gives no more dyestuff formation with diazo-benzene in
an acetic acid solution
When the chlorination is complete, the reaction mixture is poured into 1,000
parts of water and treated with a dilute sodium bisulfite solution, until no
more reaction may be observed with starch potassium iodide paper. Thereby
the 5,7-dichloro-8-hydroxy-quinaldine separates out in form of a weakly
yellowish colored precipitate. The same is filtered off and thoroughly washed
with water.After drying, 15 parts of 5,7-dichloro-8-hydroxy-quinaldine melting at 111°C
to 112°C are obtained. When recrystallized from alcohol, the product is
obtained in voluminous, slightly yellowish needles having the melting point of
111.5°C to 112°C.
Therapeutic Function
Antibacterial
Purification Methods
Crystallise it from EtOH. [Beilstein 21/3 V 346.]
5,7-Dichloro-8-hydroxyquinaldine Preparation Products And Raw materials
Raw materials
Preparation Products
5,7-Dichloro-8-hydroxyquinaldine Suppliers
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View Lastest Price from 5,7-Dichloro-8-hydroxyquinaldine manufacturers
- Product
- 5,7-dichloro-2-methylquinolin-8-ol 72-80-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- chlorquinaldol 72-80-0
- Price
- US $0.00/g
- Min. Order
- 100g
- Purity
- 99.99%
- Supply Ability
- 10000
- Release date
- 2021-09-01
- Product
- 5,7-Dichloro-8-hydroxyquinaldine 72-80-0
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-28