ChemicalBook > CAS DataBase List > 5,7-Dichloro-8-hydroxyquinaldine

5,7-Dichloro-8-hydroxyquinaldine

Product Name
5,7-Dichloro-8-hydroxyquinaldine
CAS No.
72-80-0
Chemical Name
5,7-Dichloro-8-hydroxyquinaldine
Synonyms
Quesil;Siogen;Siogene;Siogeno;Siosept;Afungil;Intensol;Saprosan;Siogenal;Siogenon
CBNumber
CB4728346
Molecular Formula
C10H7Cl2NO
Formula Weight
228.07
MOL File
72-80-0.mol
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5,7-Dichloro-8-hydroxyquinaldine Property

Melting point:
108-112 °C (dec.)(lit.)
Boiling point:
350.7±37.0 °C(Predicted)
Density 
1.3126 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO, Methaol (Slightly)
form 
Solid
pka
2.47±0.30(Predicted)
color 
Dark Beige to Very Dark Beige
Water Solubility 
Insoluble
Merck 
13,2209
BRN 
156683
CAS DataBase Reference
72-80-0(CAS DataBase Reference)
NIST Chemistry Reference
Chlorquinaldol(72-80-0)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
22-36/37/38-23/24/25
Safety Statements 
26-36-36/37/39-45
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
VC5600000
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
130532
Product name
5,7-Dichloro-8-hydroxy-2-methylquinoline
Purity
98%
Packaging
10g
Price
$62.2
Updated
2024/03/01
Cayman Chemical
Product number
29396
Product name
Chlorquinaldol
Packaging
10g
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
29396
Product name
Chlorquinaldol
Packaging
25g
Price
$94
Updated
2024/03/01
Cayman Chemical
Product number
29396
Product name
Chlorquinaldol
Packaging
50g
Price
$177
Updated
2024/03/01
TRC
Product number
D436823
Product name
5,7-Dichloro-8-hydroxy-2-methylquinoline
Packaging
500mg
Price
$45
Updated
2021/12/16
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5,7-Dichloro-8-hydroxyquinaldine Chemical Properties,Usage,Production

Chemical Properties

yellowish to beige-brown powder

Originator

Sterosan ,Geigy ,US ,1954

Uses

Chlorquinaldol is a fungistat and antibacterial agent in topical pharmaceutical preparations (5,7-dichloro-2-methyl-8-quinolinol, Sterosan).

Uses

antiinfectant, antifungal

Uses

5,7-Dichloro-8-hydroxy-2-methylquinoline is an anti-infective agent.

Definition

ChEBI: A monohydroxyquinoline that is quinolin-8-ol which is substituted by a methyl group at position 2 and by chlorine at positions 5 and 7. An antifungal and antibacterial, it was formerly used for topical treatment of skin conditions and vaginal infections.

Manufacturing Process

11.1 parts of 8-hydroxy-quinaldine are dissolved in 140 parts of formic acid. Chlorine is introduced into this solution under cooling, until the increase in weight corresponds to the required quantity of chlorine and a test of the chlorination mixtures gives no more dyestuff formation with diazo-benzene in an acetic acid solution
When the chlorination is complete, the reaction mixture is poured into 1,000 parts of water and treated with a dilute sodium bisulfite solution, until no more reaction may be observed with starch potassium iodide paper. Thereby the 5,7-dichloro-8-hydroxy-quinaldine separates out in form of a weakly yellowish colored precipitate. The same is filtered off and thoroughly washed with water.After drying, 15 parts of 5,7-dichloro-8-hydroxy-quinaldine melting at 111°C to 112°C are obtained. When recrystallized from alcohol, the product is obtained in voluminous, slightly yellowish needles having the melting point of 111.5°C to 112°C.

Therapeutic Function

Antibacterial

Purification Methods

Crystallise it from EtOH. [Beilstein 21/3 V 346.]

5,7-Dichloro-8-hydroxyquinaldine Preparation Products And Raw materials

Raw materials

Preparation Products

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5,7-Dichloro-8-hydroxyquinaldine Suppliers

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View Lastest Price from 5,7-Dichloro-8-hydroxyquinaldine manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Chlorquinaldol 72-80-0
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-09-05
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
5, 7-Dichloro-8-Hydroxyquinaldine 72-80-0
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-11-08
Honest Joy Holdings Limited
Product
5,7-dichloro-2-methylquinolin-8-ol 72-80-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98.1%
Supply Ability
100 tons
Release date
2022-02-18

72-80-0, 5,7-Dichloro-8-hydroxyquinaldineRelated Search:

PIERICIDIN A Clotrimazole Antimicrobial 5-CHLOROQUINOLINE Halquinol 2,4-Dichlorophenol 5-Chloro-8-hydroxyquinoline 5,7-Dichloro-8-hydroxyquinaldine 8-Hydroxyquinaldine 5,7-Dichloro-8-hydroxyquinoline 7-Chloro-2-methylquinoline 7-CHLOROQUINOLINE 5-Chloroquinaldine 5,7-DICHLORO-2-METHYLQUINOLINE 8-HYDROXYQUINOLINE HYDROCHLORIDE 3-[(5,7-dichloro-2-methylquinolin-8-yl)oxy]propanoic acid (5,7-DICHLORO-2-METHYL-QUINOLIN-8-YLOXY)-ACETIC ACID HYDRAZIDE (5,7-DICHLORO-2-METHYL-QUINOLIN-8-YLOXY)-ACETIC ACID

  • 5,7-DICHLORO-8-HYDROXYQUINALIDNE
  • Chlorquinalol
  • CHLORQUINALDOL(RG)
  • 2-METHYL-5,7-DICHLORO-8-HYDROXYQUINOLINE
  • 5,7-Dichloro-2-methyl-8-hydroxyquinoline
  • 5,7-DICHLORO-8-QUINALDOL
  • 5,7-Dichloro-8-hydroxy-2-methylquinoline
  • 5,7-Dichloro-8-hydroxyquinalidine
  • 5,7-DICHLORO-8-HYDROXYQUINALDINE 98+%
  • 5,7-Dichloro-2-methyl-8-quinolinol, 5,7-Dichloro-8-hydroxyquinaldine, 5,7-Dichloro-8-quinaldinol, BCM
  • Gyno-Sterosan
  • Gynotherax
  • Hydroxydichloroquinaldine
  • Hydroxydichloroquinaldinol
  • Intensol
  • Quesil
  • Quinolin-8-ol, 5,7-dichloro-2-methyl-
  • Saprosan
  • Siasteran
  • Siogen
  • Siogenal
  • Siogene
  • Siogeno
  • Siogenon
  • Siosept
  • Siosteran
  • Sterosan
  • Steroxin
  • Sterozan
  • Vagisteran
  • CHLORQUINALDOL
  • 5,7-DICHLORO-2-METHYL-8-QUINOLINOL
  • 5,7-DICHLORO-2-METHYLQUINOLIN-8-OL
  • 5,7-DICHLORO-8-HYDROXYQUINALDINE
  • 5,7-DICHLORO-8-QUINALDINOL
  • 5,7-Dichloro-8-quinaldinol,98%
  • 5,7-Dichloro-8-hydroxy-2-methylquinoline,5,7-Dichloro-2-methyl-8-quinolinol, 5,7-Dichloro-8-hydroxyquinaldine, 5,7-Dichloro-8-quinaldinol, BCM
  • 5,7-Dichloro-2-Methy
  • 5,7-Dichloro-8-hydroxyquinaldine, 5,7-Dichloro-2-methylquinolin-8-ol, Chlorquinaldol
  • 5,7-Dichloro-8-hydroxyquildine
  • 5,7-dichloro-2-methyl-8-quinolino
  • 8-Quinolinol, 5,7-dichloro-2-methyl-
  • Afungil
  • Chloquinan
  • Chlorchinaldin
  • Chlorchinaldol
  • Chlorguinaldon
  • chloroquinaldol
  • Clorquinaldol
  • Florabina
  • 5,7-Dichloro-8-hydroxy-2-Methylquinoline 98%
  • Chloquinan(Chlorquinaldol)
  • 7-Dichloro-8-hydroxy-2-methylquinoline
  • Chloroquine Impurity 4
  • 5, 7 -D i ch 1 or o-8-qui nal di no 1
  • 5,7-Dichloro-8-hydroxyquinaldine ISO 9001：2015 REACH
  • Chlorquinaldol 13CD3
  • TIANFU CHEM 5,7-Dichloro-8-hydroxyquinaldine