5,7-Dichloro-8-hydroxyquinaldine

ChemicalBook > CAS DataBase List > 5,7-Dichloro-8-hydroxyquinaldine

5,7-Dichloro-8-hydroxyquinaldine

Product Name: 5,7-Dichloro-8-hydroxyquinaldine
CAS No.: 72-80-0
Chemical Name: 5,7-Dichloro-8-hydroxyquinaldine
Synonyms: Quesil;Siogen;Siogene;Siogeno;Siosept;Afungil;Intensol;Saprosan;Siogenal;Siogenon
CBNumber: CB4728346
Molecular Formula: C10H7Cl2NO
Formula Weight: 228.07
MOL File: 72-80-0.mol

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5,7-Dichloro-8-hydroxyquinaldine Property

Melting point:: 108-112 °C (dec.)(lit.)
Boiling point:: 350.7±37.0 °C(Predicted)
Density: 1.3126 (rough estimate)
refractive index: 1.5500 (estimate)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO, Methaol (Slightly)
form: Solid
pka: 2.47±0.30(Predicted)
color: Dark Beige to Very Dark Beige
Water Solubility: Insoluble
Merck: 13,2209
BRN: 156683
CAS DataBase Reference: 72-80-0(CAS DataBase Reference)
NIST Chemistry Reference: Chlorquinaldol(72-80-0)

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Safety

Hazard Codes: Xn,T
Risk Statements: 22-36/37/38-23/24/25
Safety Statements: 26-36-36/37/39-45
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: VC5600000
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 130532
Product name: 5,7-Dichloro-8-hydroxy-2-methylquinoline
Purity: 98%
Packaging: 10g
Price: $62.2
Updated: 2024/03/01

Cayman Chemical

Product number: 29396
Product name: Chlorquinaldol
Packaging: 10g
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 29396
Product name: Chlorquinaldol
Packaging: 25g
Price: $94
Updated: 2024/03/01

Cayman Chemical

Product number: 29396
Product name: Chlorquinaldol
Packaging: 50g
Price: $177
Updated: 2024/03/01

TRC

Product number: D436823
Product name: 5,7-Dichloro-8-hydroxy-2-methylquinoline
Packaging: 500mg
Price: $45
Updated: 2021/12/16

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5,7-Dichloro-8-hydroxyquinaldine Chemical Properties,Usage,Production

Chemical Properties

yellowish to beige-brown powder

Originator

Sterosan ,Geigy ,US ,1954

Uses

Chlorquinaldol is a fungistat and antibacterial agent in topical pharmaceutical preparations (5,7-dichloro-2-methyl-8-quinolinol, Sterosan).

Uses

antiinfectant, antifungal

Uses

5,7-Dichloro-8-hydroxy-2-methylquinoline is an anti-infective agent.

Definition

ChEBI: A monohydroxyquinoline that is quinolin-8-ol which is substituted by a methyl group at position 2 and by chlorine at positions 5 and 7. An antifungal and antibacterial, it was formerly used for topical treatment of skin conditions and vaginal infections.

Manufacturing Process

11.1 parts of 8-hydroxy-quinaldine are dissolved in 140 parts of formic acid. Chlorine is introduced into this solution under cooling, until the increase in weight corresponds to the required quantity of chlorine and a test of the chlorination mixtures gives no more dyestuff formation with diazo-benzene in an acetic acid solution
When the chlorination is complete, the reaction mixture is poured into 1,000 parts of water and treated with a dilute sodium bisulfite solution, until no more reaction may be observed with starch potassium iodide paper. Thereby the 5,7-dichloro-8-hydroxy-quinaldine separates out in form of a weakly yellowish colored precipitate. The same is filtered off and thoroughly washed with water.After drying, 15 parts of 5,7-dichloro-8-hydroxy-quinaldine melting at 111°C to 112°C are obtained. When recrystallized from alcohol, the product is obtained in voluminous, slightly yellowish needles having the melting point of 111.5°C to 112°C.

Therapeutic Function

Antibacterial

Purification Methods

Crystallise it from EtOH. [Beilstein 21/3 V 346.]

5,7-Dichloro-8-hydroxyquinaldine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5,7-Dichloro-8-hydroxyquinaldine manufacturers

Honest Joy Holdings Limited

Product: 5,7-dichloro-2-methylquinolin-8-ol 72-80-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.1%
Supply Ability: 100 tons
Release date: 2022-02-18

Jiangsu Monade Biological Technology Co., Ltd.

Product: chlorquinaldol 72-80-0
Price: US $0.00/g
Min. Order: 100g
Purity: 99.99%
Supply Ability: 10000
Release date: 2021-09-01

Shaanxi Dideu Medichem Co. Ltd

Product: 5,7-Dichloro-8-hydroxyquinaldine 72-80-0
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-28

72-80-0, 5,7-Dichloro-8-hydroxyquinaldineRelated Search:

PIERICIDIN A Clotrimazole Antimicrobial 5-CHLOROQUINOLINE Halquinol 2,4-Dichlorophenol 5-Chloro-8-hydroxyquinoline 5,7-Dichloro-8-hydroxyquinaldine 8-Hydroxyquinaldine 5,7-Dichloro-8-hydroxyquinoline 7-Chloro-2-methylquinoline 7-CHLOROQUINOLINE 5-Chloroquinaldine 5,7-DICHLORO-2-METHYLQUINOLINE 8-HYDROXYQUINOLINE HYDROCHLORIDE 3-[(5,7-dichloro-2-methylquinolin-8-yl)oxy]propanoic acid (5,7-DICHLORO-2-METHYL-QUINOLIN-8-YLOXY)-ACETIC ACID HYDRAZIDE (5,7-DICHLORO-2-METHYL-QUINOLIN-8-YLOXY)-ACETIC ACID

5,7-DICHLORO-8-HYDROXYQUINALIDNE

Chlorquinalol

CHLORQUINALDOL(RG)

2-METHYL-5,7-DICHLORO-8-HYDROXYQUINOLINE

5,7-Dichloro-2-methyl-8-hydroxyquinoline

5,7-DICHLORO-8-QUINALDOL

5,7-Dichloro-8-hydroxy-2-methylquinoline

5,7-Dichloro-8-hydroxyquinalidine

5,7-DICHLORO-8-HYDROXYQUINALDINE 98+%

5,7-Dichloro-2-methyl-8-quinolinol, 5,7-Dichloro-8-hydroxyquinaldine, 5,7-Dichloro-8-quinaldinol, BCM

Gyno-Sterosan

Gynotherax

Hydroxydichloroquinaldine

Hydroxydichloroquinaldinol

Intensol

Quesil

Quinolin-8-ol, 5,7-dichloro-2-methyl-

Saprosan

Siasteran

Siogen

Siogenal

Siogene

Siogeno

Siogenon

Siosept

Siosteran

Sterosan

Steroxin

Sterozan

Vagisteran

CHLORQUINALDOL

5,7-DICHLORO-2-METHYL-8-QUINOLINOL

5,7-DICHLORO-2-METHYLQUINOLIN-8-OL

5,7-DICHLORO-8-HYDROXYQUINALDINE

5,7-DICHLORO-8-QUINALDINOL

5,7-Dichloro-8-quinaldinol,98%

5,7-Dichloro-8-hydroxy-2-methylquinoline,5,7-Dichloro-2-methyl-8-quinolinol, 5,7-Dichloro-8-hydroxyquinaldine, 5,7-Dichloro-8-quinaldinol, BCM

5,7-Dichloro-2-Methy

5,7-Dichloro-8-hydroxyquinaldine, 5,7-Dichloro-2-methylquinolin-8-ol, Chlorquinaldol

5,7-Dichloro-8-hydroxyquildine

5,7-dichloro-2-methyl-8-quinolino

8-Quinolinol, 5,7-dichloro-2-methyl-

Afungil

Chloquinan

Chlorchinaldin

Chlorchinaldol

Chlorguinaldon

chloroquinaldol

Clorquinaldol

Florabina

5,7-Dichloro-8-hydroxy-2-Methylquinoline 98%

Chloquinan(Chlorquinaldol)

7-Dichloro-8-hydroxy-2-methylquinoline

Chloroquine Impurity 4

5, 7 -D i ch 1 or o-8-qui nal di no 1

5,7-Dichloro-8-hydroxyquinaldine ISO 9001：2015 REACH

Chlorquinaldol 13CD3

TIANFU CHEM 5,7-Dichloro-8-hydroxyquinaldine