1,2-BIS(BROMOMETHYL)-4-NITROBENZENE

Product Name: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE
CAS No.: 6425-66-7
Chemical Name: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE
Synonyms: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE;Benzene, 1,2-bis(bromomethyl)-4-nitro-
CBNumber: CB9412273
Molecular Formula: C8H7Br2NO2
Formula Weight: 308.95
MOL File: 6425-66-7.mol

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1,2-BIS(BROMOMETHYL)-4-NITROBENZENE Property

Melting point:: 68-72 °C
Boiling point:: 384.6±32.0 °C(Predicted)
Density: 1.927±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Light yellow to light brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 9842AB
Product name: 1,2-Bis(bromomethyl)-4-nitrobenzene
Packaging: 250mg
Price: $181
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0142872
Product name: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE
Purity: 98.00%
Packaging: 1G
Price: $921.69
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0142872
Product name: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE
Purity: 98.00%
Packaging: 5G
Price: $1882.65
Updated: 2021/12/16

AK Scientific

Product number: 9842AB
Product name: 1,2-Bis(bromomethyl)-4-nitrobenzene
Packaging: 25g
Price: $2762
Updated: 2021/12/16

Ambeed

Product number: A102048
Product name: 1,2-Bis(bromomethyl)-4-nitrobenzene
Purity: 97%
Packaging: 100mg
Price: $65
Updated: 2021/12/16

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1,2-BIS(BROMOMETHYL)-4-NITROBENZENE Chemical Properties,Usage,Production

Synthesis

91-13-4

6425-66-7

General procedure for the synthesis of 1,2-bis(bromomethyl)-4-nitrobenzene from 1,2-bis(bromomethyl)benzene: KNO3 (33.0 g, 330 mmol) was added in batches to a stirred solution of 1,2-bis(bromomethyl)benzene (72.2 g, 300 mmol) dissolved in CH2SO4 (600 mL) at 0 °C, and the addition process lasted for 1 hour. After the addition was completed, the reaction mixture continued to be stirred at 0 °C for 3 hours. Subsequently, the reaction mixture was poured into ice water and stirred at 0 °C for 2 hours. The solid product was collected by filtration, washed with water several times and dried to afford 1,2-bis(bromomethyl)-4-nitrobenzene (63.1 g, 68% yield) as a white solid with a melting point of 73-74 °C (EtOAc/petroleum ether). The structure of the product was confirmed by 1H NMR and 13C NMR: 1H NMR (δ, ppm): 8.25 (d, J = 2.3 Hz, 1H, H-3), 8.15 (dd, J = 8.4, 2.3 Hz, 1H, H-5), 7.56 (d, J = 8.4 Hz, 1H, H-6), 4.67 (s, 2H, CH2Br), 4.66 (s, 2H, CH2Br); 13C NMR (δ, ppm): 148.0, 143.4, 138.3, 132.1, 125.9, 124.1, 28.0, 27.5 Elemental analyses are consistent with calculated values for C8H7NBr2O2: C, 31.1%; H, 2.3%; N, 4.5%. Measured values: C, 31.1%; H, 2.3%; N, 4.5%.

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 21, p. 6853 - 6865
[2] Patent: WO2006/104406, 2006, A1. Location in patent: Page/Page column 109
[3] Patent: WO2016/90079, 2016, A1. Location in patent: Paragraph 00475-00476
[4] Patent: WO2017/135897, 2017, A1. Location in patent: Page/Page column 39

1,2-BIS(BROMOMETHYL)-4-NITROBENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2-BIS(BROMOMETHYL)-4-NITROBENZENE Suppliers

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View Lastest Price from 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE manufacturers

Career Henan Chemical Co

Product: 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE 6425-66-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-14

6425-66-7, 1,2-BIS(BROMOMETHYL)-4-NITROBENZENERelated Search:

3-Nitrobenzyl bromide 4-NITRO-ALPHA,ALPHA,ALPHA',ALPHA'-TETRABROMO-O-XYLENE 4-Nitrobenzyl bromide 1,2-BIS(BROMOMETHYL)-4-NITROBENZENE

1,2-BIS(BROMOMETHYL)-4-NITROBENZENE

Benzene, 1,2-bis(bromomethyl)-4-nitro-

6425-66-7