ChemicalBook > CAS DataBase List > 2-BROMO-5-FLUORO-4-METHYLANILINE

2-BROMO-5-FLUORO-4-METHYLANILINE

Product Name
2-BROMO-5-FLUORO-4-METHYLANILINE
CAS No.
202865-78-9
Chemical Name
2-BROMO-5-FLUORO-4-METHYLANILINE
Synonyms
2-BROMO-5-FLUORO-4-METHYLANILINE;2-Bromo-5-fluoro-4-methylaniline98%;2-broMo-5-fluoro-4-MethylbenzenaMine;2-Bromo-5-fluoro-4-methylaniline 98%;BENZENAMINE,2-BROMO-5-FLUORO-4-METHYL;2-Bromo-5-fluoro-4-methyl-phenylamine;4-Amino-5-bromo-2-fluorotoluene, 2-Bromo-5-fluoro-p-toluidine
CBNumber
CB9413962
Molecular Formula
C7H7BrFN
Formula Weight
204.04
MOL File
202865-78-9.mol
More
Less

2-BROMO-5-FLUORO-4-METHYLANILINE Property

Melting point:
39-41°C
Boiling point:
245.3±35.0 °C(Predicted)
Density 
1.589±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
1.95±0.10(Predicted)
CAS DataBase Reference
202865-78-9(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37/39
Hazard Note 
Irritant
HS Code 
2921430090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

TRC
Product number
B700410
Product name
2-Bromo-5-fluoro-4-methylaniline
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
PC7405
Product name
2-Bromo-5-fluoro-4-methylaniline
Purity
98%
Packaging
1g
Price
$35
Updated
2021/12/16
SynQuest Laboratories
Product number
3730-B-25
Product name
2-Bromo-5-fluoro-4-methylaniline
Purity
98%
Packaging
1g
Price
$56
Updated
2021/12/16
Apolloscientific
Product number
PC7405
Product name
2-Bromo-5-fluoro-4-methylaniline
Purity
98%
Packaging
5g
Price
$103
Updated
2021/12/16
Matrix Scientific
Product number
097824
Product name
2-Bromo-5-fluoro-4-methylaniline
Purity
95+%
Packaging
1g
Price
$114
Updated
2021/12/16
More
Less

2-BROMO-5-FLUORO-4-METHYLANILINE Chemical Properties,Usage,Production

Synthesis

452-77-7

202865-78-9

General procedure for the synthesis of 2-bromo-5-fluoro-4-methylaniline from 3-fluoro-4-methylaniline: Step A- Synthesis of compound 28B: Compound 28A (3-fluoro-4-methylaniline, 6.00 g, 47.9 mmol) and anhydrous potassium carbonate (6.70 g, 48.5 mmol) were dissolved in anhydrous dichloromethane (130 mL), and the mixture was cooled to -15 °C in a salt-ice bath. Subsequently, a solution of bromine (7.70 g, 48.2 mmol) in anhydrous dichloromethane (80 mL) was slowly added dropwise. After the dropwise addition was completed, the reaction temperature was maintained at -15 °C and stirring was continued for 1 hour. Upon completion of the reaction, the reaction was quenched by the addition of ice water (100 mL) to the reaction mixture and the aqueous layer was extracted with dichloromethane (2 x 100 mL). The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure to afford the crude product compound 28B (2-bromo-5-fluoro-4-methylaniline, 11.0 g, quantitative yield), which could be used in subsequent steps without further purification.

References

[1] Patent: WO2009/32123, 2009, A2. Location in patent: Page/Page column 158
[2] Patent: WO2009/32125, 2009, A1. Location in patent: Page/Page column 98
[3] Patent: WO2009/32124, 2009, A1. Location in patent: Page/Page column 198-199
[4] Patent: WO2009/152200, 2009, A1. Location in patent: Page/Page column 65
[5] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 3, p. 244 - 248

2-BROMO-5-FLUORO-4-METHYLANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-BROMO-5-FLUORO-4-METHYLANILINE Suppliers

China 68 France 1 Germany 1 India 1 Italy 1 United Kingdom 9 United States 17 Global 98
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.
Tel
+86-21-54098501
Fax
+86-21-54096319
Email
sales@sinch.com.cn
Country
China
ProdList
11598
Advantage
64
Beijing Eternalchem Co,. Ltd.
Tel
010-59484199 18611897322
Email
sales@eternalchem.com
Country
China
ProdList
4383
Advantage
60
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
18209
Advantage
56
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Tianjin Anhao Biological Technology Co., Ltd.
Tel
Email
sales@ahpharmatech.com
Country
China
ProdList
5734
Advantage
55
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9858
Advantage
58
SuZhou ShiYa Biopharmaceuticals, Inc.
Tel
0512-0512-52358471 17715136450
Fax
05125235 6881
Email
sales@shiyabiopharm.com
Country
China
ProdList
12127
Advantage
58
Wuhan Chemwish Technology Co.， Ltd
Tel
027-67849912
Fax
027-87531808
Email
sales@chemwish.com
Country
China
ProdList
9148
Advantage
60
TaiChem Taizhou Limited
Tel
052386810091
Email
zcwy9518@yeah.net
Country
China
ProdList
3912
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Chengdu Xiaojia Technology Co., Ltd.
Tel
15902830537
Email
zhanghao@happysyn.com
Country
China
ProdList
3180
Advantage
55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Dalian lichuang Chemical Co., Ltd
Tel
0411-0411-00000000 13644282108
Fax
-
Email
3500508746@qq.com
Country
China
ProdList
2896
Advantage
55
Shanghai Benso Pharmaceutical Technology Co., Ltd.
Tel
15088289376
Email
248775804@qq.com
Country
China
ProdList
4995
Advantage
58
Shanghai SPAR pharmaceutical technology co., LTD
Tel
021-000000 13917643586;
Email
admin@jingshipharmatech.com
Country
China
ProdList
9856
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
12878
Advantage
58
Suzhou Wenzhi Biotechnology Co., Ltd.
Tel
13262848185
Email
20840032@qq.com
Country
China
ProdList
161
Advantage
58
Changzhou Ansciep Chemical Co., Ltd.
Tel
0519-86305871 13961213398
Email
tina@ansciepchem.com
Country
China
ProdList
1701
Advantage
58
Allfluoro pharmaceutical co. ltd.
Tel
+86-400-0216110 +86-15958047586
Fax
0086-21-33275002
Email
sales@allfluoro.com
Country
China
ProdList
11385
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Wuxi Kehua Biological Technology Co., Ltd.
Tel
0510-86838766 13636419861
Email
2258830676@qq.com
Country
China
ProdList
5044
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
sales@accelachem.com
Country
China
ProdList
10467
Advantage
58
Wuhan Chemwish Technology Co., Ltd
Tel
027-67849912
Email
sales@chemwish.com
Country
CHINA
ProdList
10821
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
Fuxin Pharmaceutical
Tel
+86-021-021-50872116 +8613122107989
Email
contact@fuxinpharm.com
Country
China
ProdList
10000
Advantage
58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel
+8613580539051
Email
joe@yuhengpharm.com
Country
CHINA
ProdList
21142
Advantage
58
Shanghai Hongju Pharmaceutical Technology Co., LTD
Tel
18001895509
Fax
QQ2934193566;
Email
986383309@qq.com
Country
China
ProdList
2680
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 4008210725
Email
malulu@leyan.com
Country
China
ProdList
40000
Advantage
58
Encyclopedia Source (Chengdu) Technology Co., Ltd.
Tel
15021461747
Email
446211270@qq.com
Country
China
ProdList
1196
Advantage
58
PharmaBlock Sciences (Nanjing), Inc.
Tel
4000255188
Fax
025 86918232
Email
sales_china@pharmablock.com
Country
China
ProdList
10000
Advantage
58
Qi Qi hang Biotechnology Co., Ltd.
Tel
15870833005
Email
2232044025@qq.com
Country
China
ProdList
8206
Advantage
58
Bide Pharmatech Ltd.
Tel
400-6005915
Email
sales@picasso-e.com
Country
China
ProdList
39653
Advantage
58
Henan Weitixi Chemical Technology Co., Ltd
Tel
0371-53370800 18037197114
Email
2853031799@qq.com
Country
China
ProdList
9892
Advantage
58
Henan Evonik Biotechnology Co. LTD
Tel
16650615803
Email
2224986086@qq.com
Country
China
ProdList
4754
Advantage
58
Anhui Henuo Biotechnology Co., Ltd
Tel
18455579438
Country
China
ProdList
16684
Advantage
58
PharmaBlock Sciences (Nanjing), Inc.
Tel
4000255188
Email
marketing@pharmablock.com
Country
China
ProdList
9126
Advantage
58
Zhuhai Aobokai Biomedical Technology Co., Ltd.
Tel
400-0628126 15697567703
Email
sales-team@aobchem.com.cn
Country
China
ProdList
49999
Advantage
58
ANQINGXINQI FINE CHEMICAL CO.,LTD.
Tel
18269792845
Email
452048049@qq.com
Country
China
ProdList
495
Advantage
58
Shandong Liteng Biotechnology Co., Ltd
Tel
18663721413 18663721413;
Email
rosy@litengpharm.com
Country
China
ProdList
1267
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Shanghai Troedsson Technology Co., LTD
Tel
18117455885
Email
qihongchem@163.com
Country
China
ProdList
9092
Advantage
58

202865-78-9, 2-BROMO-5-FLUORO-4-METHYLANILINERelated Search:

4-BROMO-2-FLUORO-5-METHYLANILINE 97% 2-BROMO-4-FLUORO-5-METHYLANILINE,2-BROMO-4-FLUORO-5-METHYLANILINE Hydrochloride 3-Fluoro-4-methylaniline 2-Bromo-5-fluoroaniline 4-Bromofluorobenzene 5-Bromo-2-fluorotoluene 4-BROMO-5-FLUORO-2-METHYLANILINE 4-Bromo-3-fluoro-2-methylaniline 2-BROMO-5-FLUORO-4-METHYLANILINE 2,6-Dibromo-3-fluoro-4-methylaniline 5-Bromo-2-fluoro-4-nitrotoluene 2'-BROMO-5'-FLUORO-4'-METHYLACETANILIDE 2-BROMO-6-FLUORO-4-METHYLANILINE 4-BROMO-2-FLUORO-5-METHYLANILINE 2-bromo-4-fluoro-N-methylaniline 2-Bromo-4-fluoro-6-methylaniline 98%,2-Bromo-4-fluoro-6-methylaniline98%,2-BROMO-4-FLUORO-6-METHYLANILINE 5-Bromo-2-fluoro-4-methylaniline 4-bromo-2-fluoro-N-methylaniline

  • 2-BROMO-5-FLUORO-4-METHYLANILINE
  • 2-Bromo-5-fluoro-4-methylaniline 98%
  • 2-broMo-5-fluoro-4-MethylbenzenaMine
  • 4-Amino-5-bromo-2-fluorotoluene, 2-Bromo-5-fluoro-p-toluidine
  • 2-Bromo-5-fluoro-4-methyl-phenylamine
  • 2-Bromo-5-fluoro-4-methylaniline98%
  • BENZENAMINE,2-BROMO-5-FLUORO-4-METHYL
  • 202865-78-9
  • Anilines, Amides & Amines
  • Bromine Compounds
  • Fluorine Compounds