2-BROMO-4-FLUORO-6-METHYLANILINE
- Product Name
- 2-BROMO-4-FLUORO-6-METHYLANILINE
- CAS No.
- 202865-77-8
- Chemical Name
- 2-BROMO-4-FLUORO-6-METHYLANILINE
- Synonyms
- 2-broMo-4-fluoro-6-MethylbenzenaMine;2-Amino-3-bromo-5-fluorotoluene;2-BROMO-4-FLUORO-6-METHYLANILINE;2-Bromo-4-fluoro-6-methylaniline98%;2-Bromo-4-fluoro-6-methylaniline 98%;2-BroMo-4-fluoro-6-Methylaniline, 97+%;BenzenaMine, 2-broMo-4-fluoro-6-Methyl-;2-BROMO-4-FLUORO-6-METHYLANILINE ISO 9001：2015 REACH
- CBNumber
- CB4371225
- Molecular Formula
- C7H7BrFN
- Formula Weight
- 204.04
- MOL File
- 202865-77-8.mol
2-BROMO-4-FLUORO-6-METHYLANILINE Property
- Melting point:
- 32-36 °C
- Boiling point:
- 248.9±35.0 °C(Predicted)
- Density
- 1.589±0.06 g/cm3(Predicted)
- Flash point:
- 110 °C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- solid
- pka
- 2.45±0.10(Predicted)
- color
- White to yellow
- InChI
- 1S/C7H7BrFN/c1-4-2-5(9)3-6(8)7(4)10/h2-3H,10H2,1H3
- InChIKey
- VTWSBILIFIFEFG-UHFFFAOYSA-N
- SMILES
- Cc1cc(F)cc(Br)c1N
- CAS DataBase Reference
- 202865-77-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 2921430090
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Acute Tox. 4 Oral
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 669369
- Product name
- 2-Bromo-4-fluoro-6-methylaniline
- Purity
- 97%
- Packaging
- 1g
- Price
- $29.1
- Updated
- 2023/06/20
- Product number
- 669369
- Product name
- 2-Bromo-4-fluoro-6-methylaniline
- Purity
- 97%
- Packaging
- 10g
- Price
- $204
- Updated
- 2023/01/07
- Product number
- B700558
- Product name
- 2-Bromo-4-fluoro-6-methylaniline
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 097823
- Product name
- 2-Bromo-4-fluoro-6-methylaniline
- Purity
- 95+%
- Packaging
- 5g
- Price
- $101
- Updated
- 2021/12/16
- Product number
- 097823
- Product name
- 2-Bromo-4-fluoro-6-methylaniline
- Purity
- 95+%
- Packaging
- 10g
- Price
- $158
- Updated
- 2021/12/16
2-BROMO-4-FLUORO-6-METHYLANILINE Chemical Properties,Usage,Production
Synthesis
452-71-1
202865-77-8
Example 1 Step a: Synthesis of 2-bromo-4-fluoro-6-methylaniline N-Bromosuccinimide (18.7 g, 0.105 mol) was dissolved in 70 mL of N,N-dimethylformamide, and the solution was added slowly and dropwise to a solution containing 4-fluoro-2-methylaniline (dissolved in 70 mL of N,N-dimethylformamide) at a reaction temperature of 20 °C. The reaction mixture was stirred overnight. The dark colored reaction solution was poured into a mixture consisting of water (1000 mL), brine (50 mL) and ethyl acetate (300 mL). The mixture was transferred to a dispensing funnel, shaken well and separated. The aqueous phase was extracted with ethyl acetate (4 x 150 mL). The organic layers were combined, washed sequentially with water (5 x 100 mL) and brine (2 x 100 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The purity of the raw material was shown to be ≥95% by 1H NMR analysis. The product was further purified by silica gel column chromatography (elution system: ethyl acetate/hexane, 1:8). The pure fractions were combined and evaporated to give 14.9 g of product. The impure fractions were combined, concentrated and redissolved in ether (30 mL) and extracted with 5% hydrochloric acid (5 x 10 mL). The acidic aqueous phase was alkalized with aqueous potassium hydroxide and then extracted with ether to give 0.8 g of the target compound. The total yield was 15.7 g (77% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm: 7.16 (dd, 3JH-F = 8.3 Hz, 4JH-H = 2.9 Hz, 1H, Ar), 6.91 (dd, 3JH-F = 9.3 Hz, 4JH-H = 2.9 Hz, 1H, Ar), 4.83 (br.s, 2H, NH2), 2.16 (s 3H, CH3).
References
[1] Patent: WO2011/6803, 2011, A1. Location in patent: Page/Page column 34
[2] Patent: WO2014/64149, 2014, A1. Location in patent: Page/Page column 27
[3] Chinese Journal of Chemistry, 2018, vol. 36, # 9, p. 815 - 818
2-BROMO-4-FLUORO-6-METHYLANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-BROMO-4-FLUORO-6-METHYLANILINE manufacturers
- Product
- 2-BROMO-4-FLUORO-6-METHYLANILINE 202865-77-8
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-30