ChemicalBook > CAS DataBase List > 2-BROMO-4-FLUORO-6-METHYLANILINE

2-BROMO-4-FLUORO-6-METHYLANILINE

Product Name: 2-BROMO-4-FLUORO-6-METHYLANILINE
CAS No.: 202865-77-8
Chemical Name: 2-BROMO-4-FLUORO-6-METHYLANILINE
Synonyms: 2-broMo-4-fluoro-6-MethylbenzenaMine;2-Amino-3-bromo-5-fluorotoluene;2-BROMO-4-FLUORO-6-METHYLANILINE;2-Bromo-4-fluoro-6-methylaniline98%;2-Bromo-4-fluoro-6-methylaniline 98%;2-BroMo-4-fluoro-6-Methylaniline, 97+%;BenzenaMine, 2-broMo-4-fluoro-6-Methyl-;2-BROMO-4-FLUORO-6-METHYLANILINE ISO 9001：2015 REACH
CBNumber: CB4371225
Molecular Formula: C7H7BrFN
Formula Weight: 204.04
MOL File: 202865-77-8.mol

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2-BROMO-4-FLUORO-6-METHYLANILINE Property

Melting point:: 32-36 °C
Boiling point:: 248.9±35.0 °C(Predicted)
Density: 1.589±0.06 g/cm3(Predicted)
Flash point:: 110 °C
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: solid
pka: 2.45±0.10(Predicted)
color: White to yellow
CAS DataBase Reference: 202865-77-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38-22
Safety Statements: 26-36/37/39
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2921430090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 669369
Product name: 2-Bromo-4-fluoro-6-methylaniline
Purity: 97%
Packaging: 1g
Price: $29.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 669369
Product name: 2-Bromo-4-fluoro-6-methylaniline
Purity: 97%
Packaging: 10g
Price: $204
Updated: 2023/01/07

TRC

Product number: B700558
Product name: 2-Bromo-4-fluoro-6-methylaniline
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Matrix Scientific

Product number: 097823
Product name: 2-Bromo-4-fluoro-6-methylaniline
Purity: 95+%
Packaging: 5g
Price: $101
Updated: 2021/12/16

Matrix Scientific

Product number: 097823
Product name: 2-Bromo-4-fluoro-6-methylaniline
Purity: 95+%
Packaging: 10g
Price: $158
Updated: 2021/12/16

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2-BROMO-4-FLUORO-6-METHYLANILINE Chemical Properties,Usage,Production

Synthesis

452-71-1

202865-77-8

Example 1 Step a: Synthesis of 2-bromo-4-fluoro-6-methylaniline N-Bromosuccinimide (18.7 g, 0.105 mol) was dissolved in 70 mL of N,N-dimethylformamide, and the solution was added slowly and dropwise to a solution containing 4-fluoro-2-methylaniline (dissolved in 70 mL of N,N-dimethylformamide) at a reaction temperature of 20 °C. The reaction mixture was stirred overnight. The dark colored reaction solution was poured into a mixture consisting of water (1000 mL), brine (50 mL) and ethyl acetate (300 mL). The mixture was transferred to a dispensing funnel, shaken well and separated. The aqueous phase was extracted with ethyl acetate (4 x 150 mL). The organic layers were combined, washed sequentially with water (5 x 100 mL) and brine (2 x 100 mL), dried over anhydrous sodium sulfate, filtered and concentrated. The purity of the raw material was shown to be ≥95% by 1H NMR analysis. The product was further purified by silica gel column chromatography (elution system: ethyl acetate/hexane, 1:8). The pure fractions were combined and evaporated to give 14.9 g of product. The impure fractions were combined, concentrated and redissolved in ether (30 mL) and extracted with 5% hydrochloric acid (5 x 10 mL). The acidic aqueous phase was alkalized with aqueous potassium hydroxide and then extracted with ether to give 0.8 g of the target compound. The total yield was 15.7 g (77% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm: 7.16 (dd, 3JH-F = 8.3 Hz, 4JH-H = 2.9 Hz, 1H, Ar), 6.91 (dd, 3JH-F = 9.3 Hz, 4JH-H = 2.9 Hz, 1H, Ar), 4.83 (br.s, 2H, NH2), 2.16 (s 3H, CH3).

References

[1] Patent: WO2011/6803, 2011, A1. Location in patent: Page/Page column 34
[2] Patent: WO2014/64149, 2014, A1. Location in patent: Page/Page column 27
[3] Chinese Journal of Chemistry, 2018, vol. 36, # 9, p. 815 - 818

2-BROMO-4-FLUORO-6-METHYLANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMO-4-FLUORO-6-METHYLANILINE Suppliers

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View Lastest Price from 2-BROMO-4-FLUORO-6-METHYLANILINE manufacturers

Career Henan Chemical Co

Product: 2-BROMO-4-FLUORO-6-METHYLANILINE 202865-77-8
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-30

202865-77-8, 2-BROMO-4-FLUORO-6-METHYLANILINERelated Search:

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2-BROMO-4-FLUORO-6-METHYLANILINE

2-Bromo-4-fluoro-6-methylaniline 98%

2-Bromo-4-fluoro-6-methylaniline98%

2-broMo-4-fluoro-6-MethylbenzenaMine

BenzenaMine, 2-broMo-4-fluoro-6-Methyl-

2-BroMo-4-fluoro-6-Methylaniline, 97+%

2-BROMO-4-FLUORO-6-METHYLANILINE ISO 9001：2015 REACH

2-Amino-3-bromo-5-fluorotoluene

202865-77-8

C7H7BrFN

Building Blocks

Amines

Nitrogen Compounds

Organic Building Blocks

C7-C8

Chemical Synthesis

Fluorinated Building Blocks

Nitrogen Compounds

Organic Building Blocks

Organic Fluorinated Building Blocks

Other Fluorinated Organic Building Blocks

Aryl Fluorinated Building Blocks

Building Blocks

Amines

Nitrogen Compounds