5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE

Product Name: 5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE
CAS No.: 70978-54-0
Chemical Name: 5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE
Synonyms: 5-BROMO-2-HYDROXY-3-NITROACETOPHENONE;3-BROMO-6-HYDROXY-5-NITRO ACETOPHENONE;5'-Bromo-2'-hydroxy-3'-nitroacetophenone;1-(5-BROMO-2-HYDROXY-3-NITROPHENYL)ETHANONE;5'-Bromo-2'-hydroxy-3'-nitroacetophenone >1-(5-Bromo-2-hydroxy-3-nitrophenyl)ethan-1-one;Ethanone, 1-(5-bromo-2-hydroxy-3-nitrophenyl)-;5′-Bromo-2′-hydroxy-3′-nitroacetophenone, CAS 70978-54-0;JRH-01018, 1-(5-Bromo-2-hydroxy-3-nitrophenyl)ethanone, 97%
CBNumber: CB9417788
Molecular Formula: C8H6BrNO4
Formula Weight: 260.04
MOL File: 70978-54-0.mol

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5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE Property

Melting point:: 129-132 °C(lit.)
Boiling point:: 272.9℃
Density: 1.763
Flash point:: 118.9℃
storage temp.: Sealed in dry,Room Temperature
form: powder to crystal
pka: 6.47±0.38(Predicted)
color: Light yellow to Yellow to Orange
CAS DataBase Reference: 70978-54-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29145090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 534153
Product name: 5′-Bromo-2′-hydroxy-3′-nitroacetophenone
Purity: 97%
Packaging: 25g
Price: $38.78
Updated: 2025/07/31

TCI Chemical

Product number: B4556
Product name: 5'-Bromo-2'-hydroxy-3'-nitroacetophenone
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $87
Updated: 2025/07/31

TCI Chemical

Product number: B4556
Product name: 5'-Bromo-2'-hydroxy-3'-nitroacetophenone
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $263
Updated: 2025/07/31

TRC

Product number: B684580
Product name: 1-(5-Bromo-2-hydroxy-3-nitrophenyl)ethanone
Packaging: 25g
Price: $130
Updated: 2021/12/16

Oakwood

Product number: 012081
Product name: 5'-Bromo-2'-hydroxy-3'-nitroacetophenone
Packaging: 1g
Price: $10
Updated: 2021/12/16

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5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE Chemical Properties,Usage,Production

Uses

5'-Bromo-2'-hydroxy-3'-nitroacetophenone is used as a chemical reagent in the synthesis of amides and benzoxazoles directly using a sulfate catalyst and microwaves. 1-(5-Bromo-2-hydroxy-3-nitrophen yl)ethanone is used in studies involving HIV-1 integrase inhibitors.

Preparation

Preparation by nitration of 5-bromo-2-hydroxyacetophenone in refluxing carbon tetrachloride (88%).

Synthesis

1450-75-5

70978-54-0

1. Synthesis of 5-bromo-2-hydroxy-3-nitroacetophenone To a solution of 5-bromo-2-hydroxyacetophenone (23.7 g, 0.110 mol) in carbon tetrachloride (90 mL) was slowly added concentrated nitric acid (17.2 mL). The reaction mixture was stirred at 75 °C for 50 min and subsequently cooled to room temperature. The precipitated solid was collected by filtration and washed with cold carbon tetrachloride. After vacuum drying, 20.9 g of the target product 5-bromo-2-hydroxy-3-nitroacetophenone was obtained as a light yellow solid in 73% yield. 1H NMR (300 MHz, CDCl3) δ: 2.73 (s, 3H), 8.14 (d, 1H), 8.31 (d, 1H), 12.92 (s, 1H).

References

[1] Patent: US5990142, 1999, A
[2] Patent: EP1391451, 2004, A1. Location in patent: Page 113
[3] Patent: WO2017/221002, 2017, A1. Location in patent: Page/Page column 92

5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE Suppliers

Americas 1 Australia 2 Belgium 1 Canada 2 China 57 Europe 1 Germany 4 India 33 Japan 3 Switzerland 1 The Netherlands 1 United Kingdom 12 United States 30 Global 148

Alfa Aesar, Thermo Fisher Scientific

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ABCR GmbH & CO. KG

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Service Chemical Inc.

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70978-54-0, 5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONERelated Search:

Acetophenone alpha-bromo-4-hydroxy-3-nitroacetophenone,2-BROMO-4'-HYDROXY-3'-NITROACETOPHENONE 5-bromo-2-hydroxy-3-nitroacetophenone,1-(5-bromo-2-hydroxy-3-nitrophenyl)ethanone 2-BROMO-2'-HYDROXY-5'-NITROACETOPHENONE 5-BroMo-3-nitrosalicylaldehyde 2-BROMO-1-(5-BROMO-2-METHOXY-3-NITROPHENYL)ETHANONE 2-BROMO-1-(5-BROMO-2-HYDROXY-3-NITROPHENYL)ETHANONE 3-Amino-2-hydroxyacetophenone 5'-BROMO-2'-HYDROXY-3'-NITROPROPIOPHENONE 3-BROMO-5-NITROBENZALDEHYDE 5'-BROMO-2'-HYDROXY-3'-NITROACETOPHENONE 2-HYDROXY-3-NITROACETOPHENONE

1-(5-BROMO-2-HYDROXY-3-NITROPHENYL)ETHANONE

3-BROMO-6-HYDROXY-5-NITRO ACETOPHENONE

5-BROMO-2-HYDROXY-3-NITROACETOPHENONE

JRH-01018, 1-(5-Bromo-2-hydroxy-3-nitrophenyl)ethanone, 97%

5'-Bromo-2'-hydroxy-3'-nitroacetophenone &gt

Ethanone, 1-(5-bromo-2-hydroxy-3-nitrophenyl)-

1-(5-Bromo-2-hydroxy-3-nitrophenyl)ethan-1-one

5'-Bromo-2'-hydroxy-3'-nitroacetophenone

5′-Bromo-2′-hydroxy-3′-nitroacetophenone, CAS 70978-54-0

70978-54-0

BrC6H2NO2OHCOCH3

C8H6BrNO4

Building Blocks

C7 to C8

Carbonyl Compounds

Organic Building Blocks

Ketones

Aromatic Acetophenones & Derivatives (substituted)

Building Blocks

C7 to C8

Carbonyl Compounds

Chemical Synthesis

Ketones

Organic Building Blocks