ChemicalBook > CAS DataBase List > I-BET 151 hydrochloride
I-BET 151 hydrochloride
- Product Name
- I-BET 151 hydrochloride
- CAS No.
- 1883545-47-8
- Chemical Name
- I-BET 151 hydrochloride
- Synonyms
- I-BET 151 2HCl;I-BET 151 hydrochloride;I-BET 151 dihydrochloride;I BET151 dihydrochloride,I-BET-151 dihydrochloride,IBET151 dihydrochloride;7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride
- CBNumber
- CB94189029
- Molecular Formula
- C23H22ClN5O3
- Formula Weight
- 451.91
- MOL File
- 1883545-47-8.mol
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I-BET 151 hydrochloride Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥22.05 mg/mL in EtOH; ≥31.7 mg/mL in DMSO
- form
- solid
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N-Bromosuccinimide Price
Tocris
- Product number
- 4650
- Product name
- I-BET151dihydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $255
- Updated
- 2021/12/16
Tocris
- Product number
- 4650
- Product name
- I-BET151dihydrochloride
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $1045
- Updated
- 2021/12/16
TRC
- Product number
- I120058
- Product name
- I-BET151Dihydrochloride
- Packaging
- 1mg
- Price
- $125
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- BI162773
- Product name
- I-BET 151 dihydrochloride
- Packaging
- 10mg
- Price
- $145
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B5670
- Product name
- I-BET151hydrochloride
- Packaging
- 5mg
- Price
- $96
- Updated
- 2021/12/16
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I-BET 151 hydrochloride Chemical Properties,Usage,Production
Biological Activity
i-bet 151 dihydrochloride is a bet bromodomain inhibitor that prevents bet from recruiting to chromatin. i-bet 151 induces mll-fusion leukemia cell line apoptosis and g0 / g1 cell cycle arrest in vitro, and reduces bcl2 expression in nomo1 cells. i-bet 151 improves the survival rate of two kinds of mll fusion leukemia mice, and enhances the differentiation of human ipscs into megakaryocytes.[1]. malherbe p, masciadri r, norcross r d, et al. characterization of (r,s)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3h-benzofuran-2-one as a positive allosteric modulator of gabab receptors. british journal of pharmacology, 2008, 154(4): 797.
storage
-20°C
I-BET 151 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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