Propargylcholine
- Product Name
- Propargylcholine
- CAS No.
- 111755-76-1
- Chemical Name
- Propargylcholine
- Synonyms
- Propargylcholine;Propargylcholine (bromide);Alkyne-choline (hydrobromide);Propargylcholine, 10 mM in DMSO;(2-HYDROXYETHYL)DIMETHYL(PROP-2-YN-1-YL)AZANIUM BROMIDE;N-(2-hydroxyethyl)-N,N-dimethylprop-2-yn-1-aminium bromide;N-(2-hydroxyethyl)-N,N-dimethyl-2-propyn-1-aminium,monobromide;2-Propyn-1-aminium, N-(2-hydroxyethyl)-N,N-dimethyl-, bromide (1:1)
- CBNumber
- CB94200319
- Molecular Formula
- C7H14BrNO
- Formula Weight
- 208.09616
- MOL File
- 111755-76-1.mol
Propargylcholine Property
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
- form
- A crystalline solid
- color
- Off-white to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 25870
- Product name
- Propargylcholine (bromide)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 25870
- Product name
- Propargylcholine (bromide)
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 25870
- Product name
- Propargylcholine (bromide)
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $347
- Updated
- 2024/03/01
- Product number
- 25870
- Product name
- Propargylcholine (bromide)
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $780
- Updated
- 2024/03/01
- Product number
- 174729
- Product name
- N-(2-Hydroxyethyl)-N,N-dimethyl-2-propyn-1-ammonium bromide
- Packaging
- 5g
- Price
- $1206
- Updated
- 2021/12/16
Propargylcholine Chemical Properties,Usage,Production
Description
Propargylcholine bromide is an alkynyl derivative of choline that has a propargyl group in place of one methyl group. It can be used to assay phospholipid synthesis and localization in cells and tissues using Raman scattering microscopy or click chemistry labeling with fluorescent or affinity-tagged azides.
Uses
Propargylcholine bromide is a choline analogue containing terminal propargyl that can be incorporated into all classes of Choline-containing phospholipids such as phosphatidylcholine and sphingomyelin, labeling Choline-containing phospholipids. Propargylcholine bromide-labeled phospholipid molecules can be visualized in cells with high sensitivity and spatial resolution. Propargylcholine bromide can be used as a molecular tool to study the biochemical and metabolic processes of Choline-containing phospholipids in cells[1][2]. Propargylcholine (bromide) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
Propargylcholine bromide (P-Cho; 3.5-4.0 mg/kg; i.p; single daily for 6 days) effectively incorporates into newly synthesized myelin within 1 week of dosing and sustained presence beyond 6 weeks in rhesus monkey[2].
References
[1] Jao CY, et al. Metabolic labeling and direct imaging of choline phospholipids in vivo. Proc Natl Acad Sci U S A. 2009 Sep 8;106(36):15332-7. DOI:10.1073/pnas.0907864106
[2] Karen R. Bottenfield, et al. Optimization of Propargylcholine to Label Newly Synthesized Myelin in the Rhesus Monkey Brain. FASEB J. 2020, 34(S1): 1-1.
Propargylcholine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Propargylcholine manufacturers
- Product
- Alkyne-choline (hydrobromide) 111755-76-1
- Price
- US $0.00/mg
- Min. Order
- 10mg
- Purity
- >95.00%
- Supply Ability
- 10mg
- Release date
- 2024-03-21