ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE

Product Name: ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE
CAS No.: 100123-25-9
Chemical Name: ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE
Synonyms: ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE;5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate - [E37736];1H-Indole-2-carboxylic acid, 5-bromo-3-formyl-, ethyl ester
CBNumber: CB9428546
Molecular Formula: C12H10BrNO3
Formula Weight: 296.12
MOL File: 100123-25-9.mol

More

Less

ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE Property

Melting point:: 245 °C(Solv: ethanol (64-17-5))
Boiling point:: 476.7±45.0 °C(Predicted)
Density: 1.608±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 12.56±0.30(Predicted)
Appearance: Off-white to light yellow Solid

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: E702910
Product name: Ethyl5-Bromo-3-formyl-1H-indole-2-carboxylate
Packaging: 100mg
Price: $105
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0035738
Product name: ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 2G
Price: $2021.25
Updated: 2021/12/16

Ambeed

Product number: A190769
Product name: Ethyl5-bromo-3-formyl-1H-indole-2-carboxylate
Purity: 98%
Packaging: 250mg
Price: $66
Updated: 2021/12/16

Crysdot

Product number: CD11370601
Product name: Ethyl5-bromo-3-formyl-1H-indole-2-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $74
Updated: 2021/12/16

Ambeed

Product number: A190769
Product name: Ethyl5-bromo-3-formyl-1H-indole-2-carboxylate
Purity: 98%
Packaging: 1g
Price: $146
Updated: 2021/12/16

More

Less

ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Ethyl 5-Bromo-3-formyl-1h-indole-2-carboxylate is a versatile building block. It was used as a reactant in the synthetic preparation of hydroxyindolecarboxylates by Baeyer-Villiger oxidation.

Synthesis

16732-70-0

100123-25-9

Oxalyl chloride (3.43 mL, 39.9 mmol) was slowly added dropwise to a mixed solution containing DMF (30 mL) and dichloromethane (80 mL) at 0 °C while maintaining stirring. After the dropwise addition was completed, stirring was continued at 0 °C for 20 min. Subsequently, a solution of ethyl 5-bromoindole-2-carboxylate (10 g, 37.3 mmol) dissolved in DMF (80 mL) was added. The reaction mixture was transferred to room temperature and stirred continuously for 24 hours. Upon completion of the reaction, the mixture was poured into saturated aqueous sodium bicarbonate solution and extracted with dichloromethane. The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Finally, the target product ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate was obtained by ethanol recrystallization in a yield of 8.9 g and 81%.

References

[1] Patent: WO2006/77366, 2006, A1. Location in patent: Page/Page column 152
[2] Patent: WO2006/77367, 2006, A1. Location in patent: Page/Page column 89

ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE Suppliers

China 40 Germany 1 India 1 Russia 1 United Kingdom 1 United States 7 Global 51

Shanghai ChuangYan Chemical Technology Co., Ltd.

Tel: 021-11111111 11111111111
Fax: qq:546919421
Email: 546919421@qq.com
Country: China
ProdList: 3519
Advantage: 55

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Yantai ShengKailun Chemical Technology Co., Ltd.

Tel: 13356901049
Fax: QQ：1025383091
Email: 3119594100@qq.com
Country: China
ProdList: 7964
Advantage: 55

Shanghai Pingguo Pharmaceutical Co., Ltd.

Tel: 021-20432229
Fax: QQ2412110556
Email: 2412110556@qq.com
Country: China
ProdList: 6017
Advantage: 55

Beijing YiboYuntian Technology Co., Ltd.

Tel: 13811826434
Fax: -
Email: lichen13811826434@126.com
Country: China
ProdList: 663
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Shanghai WangFa Chemical Technology Co., Ltd.

Tel: 13918479294
Fax: -
Email: xiebenfa@163.com
Country: China
ProdList: 4087
Advantage: 58

100123-25-9, ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATERelated Search:

3-b]pyridine 5-Bromo-4-chloro-pyrimidine hydrochloride 5-Bromo-4-methyl-1H-indazole 5-BroMo-4-Methylisothiazole 5-Bromo-3(2H)-benzofuranone 5-broMo-2-Methoxypyridin-3-ol 5-BroMo-4-chloro-1H-pyrazolo[3,4-b]pyridine METHYL 6H-THIENO[2,3-B]PYRROLE-5-CARBOXYLATE 5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl5-bromo-1,3,4-thiadiazole-2-carboxylate 4-Isoxazolecarboxylicacid,2,5-dihydro-5-oxo-,ethylester(9CI) 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one (5-BROMO-1H-INDOL-2-YL)METHANOL Ethyl 5-Bromoindole-2-carboxylate 5-Bromoindole-3-carboxaldehyde 5-Bromoindole-2-carboxylic acid 5-BROMO-1H-INDOLE-2-CARBALDEHYDE 3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER

5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLIC ACID ETHYL ESTER

ETHYL 5-BROMO-3-FORMYL-1H-INDOLE-2-CARBOXYLATE

1H-Indole-2-carboxylic acid, 5-bromo-3-formyl-, ethyl ester

Ethyl 5-bromo-3-formyl-1H-indole-2-carboxylate - [E37736]

100123-25-9