5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- Product Name
- 5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- CAS No.
- 885276-93-7
- Chemical Name
- 5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- Synonyms
- Ethyl 5-broMopyrazolo[1,5-a]pyridine-3-carboxylate;Ethyl 5-broMopyrazolo[1,5...;Ethyl 5-bromopyrazolo1,5-apyridin-3-carboxylate;ethyl 5-broMoH-pyrazolo[1,5-a]pyridine-3-carboxylate;5-Bromo-pyrazolo[1,5-a]pyridine-3-carboxylate ethyl ester;5-Bromopyrazolo[1,5-a]pyridin-3-carboxylic acid ethyl ester;5-bromo-3-pyrazolo[1,5-a]pyridinecarboxylic acid ethyl ester;Pyrazolo[1,5-a]pyridine-3-carboxylicacid, 5-bromo-, ethyl es...;5-BroMo-1H-pyrazolo[1,5-a]pyridin-3-carboxylic acid ethyl ester;Pyrazolo[1,5-a]pyridine-3-carboxylic acid, 5-broMo-, ethyl ester
- CBNumber
- CB81501902
- Molecular Formula
- C10H9BrN2O2
- Formula Weight
- 269.09
- MOL File
- 885276-93-7.mol
5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Property
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- -0.16±0.30(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H9BrN2O2/c1-2-15-10(14)8-6-12-13-4-3-7(11)5-9(8)13/h3-6H,2H2,1H3
- InChIKey
- LJKZKCQPVABNLG-UHFFFAOYSA-N
- SMILES
- C12=C(C(OCC)=O)C=NN1C=CC(Br)=C2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E900770
- Product name
- Ethyl5-bromopyrazolo[1,5-a]pyridine-3-carboxylate
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E900770
- Product name
- Ethyl5-bromopyrazolo[1,5-a]pyridine-3-carboxylate
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB56546
- Product name
- 5-Bromo-pyrazolo[1,5-a]pyridine-3-carboxylic acid ethyl ester
- Packaging
- 100g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 4H58-9-99
- Product name
- Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 212493
- Product name
- Ethyl5-bromopyrazolo[1,5-a]pyridine-3-carboxylate
- Purity
- 95%
- Packaging
- 1g
- Price
- $203
- Updated
- 2021/12/16
5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Synthesis
1533440-88-8
623-47-2
885276-93-7
General procedure for the synthesis of ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate from 1-amino-4-bromopyridinium iodide and ethyl propargylate: To a 250 mL three-necked round-bottomed flask was added 1-amino-4-bromopyridinium iodide (Compound 64.2, 15 g, ca. 50% purity, 24.9 mmol) in N,N-dimethylformamide (80 mL) Solution. Potassium carbonate (10.6 g, 76.7 mmol) was added batchwise, followed by ethyl propargylate (11.7 mL, 115 mmol) dropwise over 10 min. The reaction mixture was stirred overnight at room temperature and then diluted with ethyl acetate (300 mL) and water (100 mL). Insoluble solids were removed by filtration, and the organic layer was washed with saturated saline (3 x 50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:10) as eluent to afford ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate as a brown solid (300 mg, 6% yield).
References
[1] Patent: WO2014/8197, 2014, A1. Location in patent: Page/Page column 135
[2] Patent: WO2015/95767, 2015, A1. Location in patent: Page/Page column 150
5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER manufacturers
- Product
- 5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 885276-93-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-06
- Product
- Ethyl 5-broMopyrazolo[1,5-a]pyridine-3-carboxylate 885276-93-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- Ethyl 5-bromopyrazolo[1,5-a]pyridine-3-carboxylate 885276-93-7
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09