8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester
- Product Name
- 8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester
- CAS No.
- 206258-97-1
- Chemical Name
- 8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester
- Synonyms
- CAS:206258-97-1;Ethyl 4-chloro-8-broMoquinoline-3-carboxylate;Ethyl8-bromo-4-chloroquinoline-3-carboxylate,97%;ethyl 8-bromo-4-chloroquinoline-3-carboxylate - [E5351];8-Bromo-4-chloro-3-quinolinecarboxylic acid ethyl ester;8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester;3-Quinolinecarboxylic acid, 8-bromo-4-chloro-, ethyl ester
- CBNumber
- CB72517208
- Molecular Formula
- C12H9BrClNO2
- Formula Weight
- 314.56
- MOL File
- 206258-97-1.mol
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C12H9BrClNO2/c1-2-17-12(16)8-6-15-11-7(10(8)14)4-3-5-9(11)13/h3-6H,2H2,1H3
- InChIKey
- MLHAFVCMBUQWKC-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC=CC=2Br)C(Cl)=C(C(OCC)=O)C=1
Safety
- WGK Germany
- 3
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- BBO000341
- Product name
- 8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $332
- Updated
- 2023/06/20
- Product number
- E900688
- Product name
- Ethyl8-bromo-4-chloroquinoline-3-carboxylate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H58-D-08
- Product name
- 8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester
- Packaging
- 5G
- Price
- $336
- Updated
- 2021/12/16
- Product number
- W4335
- Product name
- Ethyl8-bromo-4-chloroquinoline-3-carboxylate
- Packaging
- 5g
- Price
- $397
- Updated
- 2021/12/16
- Product number
- 4H58-D-08
- Product name
- 8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
35975-57-6
206258-97-1
General procedure for the synthesis of ethyl 4-chloro-8-bromoquinoline-3-carboxylate from ethyl 4-hydroxy-8-bromoquinoline-3-carboxylate: ethyl 8-bromo-4-hydroxyquinoline-3-carboxylate (2.0 g, 6.75 mmol) was dissolved in phosphorus triclosan (10 mL) and heated to reflux for 3 hr at 80 °C. Upon completion of the reaction, volatiles were removed by distillation under reduced pressure and the residue was quenched with ice water. The precipitated solid was collected by filtration and dried to give 1.8 g of the target product ethyl 4-chloro-8-bromoquinoline-3-carboxylate. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6) and mass spectrometry: 1H NMR δ 9.26 (s, 1H), 8.44-8.37 (m, 2H), 7.79-7.64 (t, J = 7.8 Hz, 1H), 4.48-4.43 (q, J = 7.2, 14.1 Hz, 2H), 1.41-1.36 (t. J = 6.9 Hz, 3H); MS (m/z): 314.01 (M + H)+.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 8, p. 1487 - 1490
[2] Patent: US2013/210844, 2013, A1. Location in patent: Paragraph 0338; 0339
[3] Patent: CN108623590, 2018, A. Location in patent: Paragraph 0149
8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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