4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester
- Product Name
- 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester
- CAS No.
- 6317-97-1
- Chemical Name
- 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester
- Synonyms
- Nsc25750;Ethyl 4,6-dihydroxy-5-nitronicotinate;Ethyl4,6-dihydroxy-5-nitronicotinate,97%;4,6-Dihydroxy-5-nitronicotinic acid ethyl ester;ethyl 4,6-dihydroxy-5-nitropyridine-3-carboxylate;ethyl 4-hydroxy-5-nitro-6-oxo-1H-pyridine-3-carboxylate;4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester;ethyl 4,6-dihydroxy-5-nitropyridine-3-carboxylate - [AC78549];ethyl 6-hydroxy-5-nitro-4-oxo-1,4-dihydropyridine-3-carboxylate;Ethyl 4-hydroxy-5-nitro-6-oxo-1,6-dihydropyridine-3-carboxylate
- CBNumber
- CB9967450
- Molecular Formula
- C8H8N2O6
- Formula Weight
- 228.16
- MOL File
- 6317-97-1.mol
4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester Property
- Melting point:
- 243-246°
- Boiling point:
- 325.7±42.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.50±1.00(Predicted)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- E927858
- Product name
- Ethyl4,6-Dihydroxy-5-nitronicotinate
- Packaging
- 50mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CHM0011368
- Product name
- 4,6-DIHYDROXY-5-NITROPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $784.15
- Updated
- 2021/12/16
- Product number
- 048531
- Product name
- Ethyl 4,6-dihydroxy-5-nitronicotinate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 9611AB
- Product name
- Ethyl4,6-dihydroxy-5-nitronicotinate
- Packaging
- 5g
- Price
- $698
- Updated
- 2021/12/16
- Product number
- 048531
- Product name
- Ethyl 4,6-dihydroxy-5-nitronicotinate
- Purity
- >95%
- Packaging
- 5g
- Price
- $725
- Updated
- 2021/12/16
4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
6975-44-6
6317-97-1
Step 2: Preparation of ethyl 4,6-dichloro-5-nitronicotinate (15) To a solution of concentrated sulfuric acid (330 ml) of ethyl 4,6-dihydroxynicotinate (14) (40.0 g, 0.22 mol) cooled to 0°C, fuming nitric acid (12.7 ml) was added dropwise slowly. After the dropwise addition was completed, the reaction mixture was stirred at 0°C for 1 hour, then brought to room temperature and continued stirring for 1 hour. After completion of the reaction, the mixture was slowly poured into ice water and stirred vigorously for 10 minutes. The precipitate precipitated was collected by filtration, washed well with water and dried under vacuum to give a light yellow solid product 15 (38.7 g, 77.6% yield). The melting point of the product was 238-240 °C. 1H NMR (300 MHz, DMSO-d6) δ (ppm): 8.22 (s, 1H), 4.31 (q, J = 7.0 Hz, 2H), 1.29 (t, J = 7.0 Hz, 3H). MS (ESI (+) 70V) m/z: 227 [M-H]-.
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 20, p. 6551 - 6559
[2] Patent: WO2008/17696, 2008, A1. Location in patent: Page/Page column 51
[3] Patent: WO2009/106419, 2009, A1. Location in patent: Page/Page column 79
[4] Patent: WO2008/17696, 2008, A1. Location in patent: Page/Page column 51
[5] Recueil des Travaux Chimiques des Pays-Bas, 1948, vol. 67, p. 29,37
4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester manufacturers
- Product
- 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester 6317-97-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-28
- Product
- 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester 6317-97-1
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1kg; 5kg; 10kg
- Release date
- 2020-10-28