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4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester

Product Name
4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester
CAS No.
6317-97-1
Chemical Name
4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester
Synonyms
Nsc25750;Ethyl 4,6-dihydroxy-5-nitronicotinate;Ethyl4,6-dihydroxy-5-nitronicotinate,97%;4,6-Dihydroxy-5-nitronicotinic acid ethyl ester;ethyl 4,6-dihydroxy-5-nitropyridine-3-carboxylate;ethyl 4-hydroxy-5-nitro-6-oxo-1H-pyridine-3-carboxylate;4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester;ethyl 4,6-dihydroxy-5-nitropyridine-3-carboxylate - [AC78549];ethyl 6-hydroxy-5-nitro-4-oxo-1,4-dihydropyridine-3-carboxylate;Ethyl 4-hydroxy-5-nitro-6-oxo-1,6-dihydropyridine-3-carboxylate
CBNumber
CB9967450
Molecular Formula
C8H8N2O6
Formula Weight
228.16
MOL File
6317-97-1.mol
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4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester Property

Melting point:
243-246°
Boiling point:
325.7±42.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.50±1.00(Predicted)
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
E927858
Product name
Ethyl4,6-Dihydroxy-5-nitronicotinate
Packaging
50mg
Price
$65
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0011368
Product name
4,6-DIHYDROXY-5-NITROPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
Purity
95.00%
Packaging
1G
Price
$784.15
Updated
2021/12/16
Matrix Scientific
Product number
048531
Product name
Ethyl 4,6-dihydroxy-5-nitronicotinate
Purity
>95%
Packaging
500mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
9611AB
Product name
Ethyl4,6-dihydroxy-5-nitronicotinate
Packaging
5g
Price
$698
Updated
2021/12/16
Matrix Scientific
Product number
048531
Product name
Ethyl 4,6-dihydroxy-5-nitronicotinate
Purity
>95%
Packaging
5g
Price
$725
Updated
2021/12/16
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4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester Chemical Properties,Usage,Production

Synthesis

6975-44-6

6317-97-1

Step 2: Preparation of ethyl 4,6-dichloro-5-nitronicotinate (15) To a solution of concentrated sulfuric acid (330 ml) of ethyl 4,6-dihydroxynicotinate (14) (40.0 g, 0.22 mol) cooled to 0°C, fuming nitric acid (12.7 ml) was added dropwise slowly. After the dropwise addition was completed, the reaction mixture was stirred at 0°C for 1 hour, then brought to room temperature and continued stirring for 1 hour. After completion of the reaction, the mixture was slowly poured into ice water and stirred vigorously for 10 minutes. The precipitate precipitated was collected by filtration, washed well with water and dried under vacuum to give a light yellow solid product 15 (38.7 g, 77.6% yield). The melting point of the product was 238-240 °C. 1H NMR (300 MHz, DMSO-d6) δ (ppm): 8.22 (s, 1H), 4.31 (q, J = 7.0 Hz, 2H), 1.29 (t, J = 7.0 Hz, 3H). MS (ESI (+) 70V) m/z: 227 [M-H]-.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 20, p. 6551 - 6559
[2] Patent: WO2008/17696, 2008, A1. Location in patent: Page/Page column 51
[3] Patent: WO2009/106419, 2009, A1. Location in patent: Page/Page column 79
[4] Patent: WO2008/17696, 2008, A1. Location in patent: Page/Page column 51
[5] Recueil des Travaux Chimiques des Pays-Bas, 1948, vol. 67, p. 29,37

4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester Suppliers

China 30 Germany 1 India 2 United Kingdom 1 United States 8 Global 42
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
India
ProdList
6905
Advantage
58
CHEMSWORTH
Tel
--
Fax
--
Email
info@chemsworth.com
Country
India
ProdList
6700
Advantage
30
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View Lastest Price from 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester manufacturers

Dideu Industries Group Limited
Product
4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester 6317-97-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-09-28
Career Henan Chemica Co
Product
4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester 6317-97-1
Price
US $0.01/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1kg; 5kg; 10kg
Release date
2020-10-28

6317-97-1, 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl esterRelated Search:

2-CYANO-5-ETHOXYCARBONYLPYRIDINE 4,6-DICHLORO-8-METHYLQUINOLINE-3-CARBOXYLIC ETHYL ESTER ethyl2-methylquinoline-6-carboxylate 1H-Pyrazole-3-carboxylicacid,4-cyano-,ethylester(9CI) ETHYL 6-BROMO-4-CHLORO-3-QUINOLINECARBOXYLATE Ethyl 4-chloro-7-methoxyquinoline- 3-carboxylate ethyl 2-bromo-4H-thieno[3,2-b]pyrrole-5-carboxylate Pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid, 1,4-dihydro-5-methyl-4-oxo-, ethyl ester 8-Bromo-4-chloroquinoline-3-carboxylic acid ethyl ester 5-BROMO-PYRAZOLO[1,5-A]PYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER 4-Hydroxy-3-nitropyridine 5-NITRONICOTINIC ACID 4,6-Dihydroxynicotinic acid 2-Hydroxy-5-methyl-3-nitropyridine 6-Hydroxy-5-nitronicotinic acid 3-AMINO-5-HYDROXYMETHYLPYRIDINE Methyl 4,6-dihydroxynicotinate 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester

  • 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester
  • 4,6-Dihydroxy-5-nitronicotinic acid ethyl ester
  • Ethyl 4,6-dihydroxy-5-nitronicotinate
  • Nsc25750
  • ethyl 4,6-dihydroxy-5-nitropyridine-3-carboxylate
  • 3-Pyridinecarboxylic acid, 1,6-dihydro-4-hydroxy-5-nitro-6-oxo-, ethyl ester
  • Ethyl4,6-dihydroxy-5-nitronicotinate,97%
  • 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester ISO 9001：2015 REACH
  • Ethyl 4-hydroxy-5-nitro-6-oxo-1,6-dihydropyridine-3-carboxylate
  • ethyl 4-hydroxy-5-nitro-6-oxo-1H-pyridine-3-carboxylate
  • ethyl 6-hydroxy-5-nitro-4-oxo-1,4-dihydropyridine-3-carboxylate
  • ethyl 4,6-dihydroxy-5-nitropyridine-3-carboxylate - [AC78549]
  • 6317-97-1