6-Hydroxy-5-nitronicotinic acid
- Product Name
- 6-Hydroxy-5-nitronicotinic acid
- CAS No.
- 6635-31-0
- Chemical Name
- 6-Hydroxy-5-nitronicotinic acid
- Synonyms
- 135339;6-Hydroxy-5-Nitro Niacin;6-hyroxy-5-nitronicotinic acid;6-HYDROXY-5-NITRONICOTINIC ACID;5-Nitro-6-hydroxynicotinic acid;6-Hydroxy-5-nitronicotinicAcid>5-CARBOXY-3-NITRO-2(1H)-PYRIDINONE;6-Hydroxy-5-nitronicotinic acid 97%;6-Hydroxy-5-nitropyridine-3-carboxylicaci;6-Hydroxy-5-nitropyridin-3-carboxylic acid
- CBNumber
- CB3671957
- Molecular Formula
- C6H4N2O5
- Formula Weight
- 184.11
- MOL File
- 6635-31-0.mol
6-Hydroxy-5-nitronicotinic acid Property
- Melting point:
- 269-271
- Boiling point:
- 363.6±42.0 °C(Predicted)
- Density
- 1.70±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- powder to crystal
- pka
- 3.09±0.50(Predicted)
- color
- Light yellow to Yellow
- BRN
- 177986
- InChI
- InChI=1S/C6H4N2O5/c9-5-4(8(12)13)1-3(2-7-5)6(10)11/h1-2H,(H,7,9)(H,10,11)
- InChIKey
- VJMXJGVEVASJOD-UHFFFAOYSA-N
- SMILES
- C1NC(=O)C([N+]([O-])=O)=CC=1C(O)=O
- CAS DataBase Reference
- 6635-31-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 669679
- Product name
- 6-Hydroxy-5-nitropyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $118
- Updated
- 2022/05/15
- Product number
- 669679
- Product name
- 6-Hydroxy-5-nitropyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $704
- Updated
- 2022/05/15
- Product number
- H1410
- Product name
- 6-Hydroxy-5-nitronicotinic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $105
- Updated
- 2024/03/01
- Product number
- H1410
- Product name
- 6-Hydroxy-5-nitronicotinic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $360
- Updated
- 2024/03/01
- Product number
- H950838
- Product name
- 6-Hydroxy-5-nitronicotinic Acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
6-Hydroxy-5-nitronicotinic acid Chemical Properties,Usage,Production
Uses
6-Hydroxy-5-nitronicotinic acid is mainly used as an antibacterial agent and pharmaceutical intermediate.
Chemical Reactivity
6-Hydroxy-5-nitronicotinic acid is stable under proper conditions, it reacts with oxidizing agents.
Synthesis
6-Hydroxy-5-nitronicotinic acid is synthesised using 6-Hydroxynicotinic acid as a raw material by chemical reaction. The specific synthesis steps are as follows:
6-Hydroxynicotinic acid 2 (25.0 g, 180 mmol) was dissolved in HNO3 fuming (1.52) (95 mL) and stirred at 50 oC for 18 h. After the solution was cooled to room temperature, the mixture was concentrated, and then co-evaporated with water, followed by the addition of MeOH to afford a brown precipitate. The precipitate was filtered and washed with 50 mL of cold MeOH twice. After drying under reduced pressure, a brown color product 3 was obtained; yield: 9.67 g (29percent); 1H NMR (300 MHz, CD3OD) 8.44 (d, J = 2.6 Hz, 1H), 8.85 (d, J = 2.6 Hz, 1H) ; HRMS (ES+): m/z 185.0194 (M+H+) (calcd for C6H5N2O5: 185.0198).
References
[1] Tetrahedron Letters, 1999, vol. 40, # 12, p. 2227 - 2230
[2] Tetrahedron Letters, 2012, vol. 53, # 5, p. 535 - 538
[3] Patent: WO2016/138335, 2016, A1. Location in patent: Paragraph 00372
[4] Journal of the American Chemical Society, 1956, vol. 78, p. 423
[5] Journal of the Chemical Society, 1951, p. 2590,2593
6-Hydroxy-5-nitronicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Hydroxy-5-nitronicotinic acid manufacturers
- Product
- 6-Hydroxy-5-nitronicotinic acid 6635-31-0
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-13
- Product
- 6-Hydroxy-5-nitronicotinic acid 6635-31-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 6-Hydroxy-5-nitronicotinic acid 6635-31-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-12