5-Aminonicotinic acid
- Product Name
- 5-Aminonicotinic acid
- CAS No.
- 24242-19-1
- Chemical Name
- 5-Aminonicotinic acid
- Synonyms
- AURORA KA-3032;JACS-24242-19-1;AKOS BBS-00001362;IFLAB-BB F1926-0005;5-Ammonionicotinate;5-Aminonicotinic aci;OTAVA-BB BB7017520056;5-AMINONICOTINIC ACID;5-AMINOISOPHTHALICACID;5-AMINOSONICOTINICACID
- CBNumber
- CB0248990
- Molecular Formula
- C6H6N2O2
- Formula Weight
- 138.12
- MOL File
- 24242-19-1.mol
5-Aminonicotinic acid Property
- Melting point:
- 293 °C
- Boiling point:
- 253.51°C (rough estimate)
- Density
- 1.3471 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 2.36±0.10(Predicted)
- form
- Crystalline Powder
- color
- Golden-brown
- BRN
- 115848
- InChI
- InChI=1S/C6H6N2O2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,7H2,(H,9,10)
- InChIKey
- BYIORJAACCWFPU-UHFFFAOYSA-N
- SMILES
- C1=NC=C(N)C=C1C(O)=O
- CAS DataBase Reference
- 24242-19-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 36/37/38-20/21/22-22
- Safety Statements
- 36/37/39-26-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 672513
- Product name
- 5-Aminopyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $94.5
- Updated
- 2025/07/31
- Product number
- 672513
- Product name
- 5-Aminopyridine-3-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $541
- Updated
- 2023/06/20
- Product number
- A2000
- Product name
- 5-Aminonicotinic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $38
- Updated
- 2025/07/31
- Product number
- A2000
- Product name
- 5-Aminonicotinic Acid
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $152
- Updated
- 2025/07/31
- Product number
- A618753
- Product name
- 5-Aminonicotinic Acid
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
5-Aminonicotinic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white Cryst
Uses
5-Aminonicotinic acid is used in the synthesis of coordination polymers, bioluminescent reagents and biological active agents.
Definition
ChEBI: 5-aminonicotinic acid is an aminonicotinic acid in which the amino group is situated at position 5 of the pyridine ring. It has a role as a metabolite. It is an aromatic amine, an aminopyridine and an aminonicotinic acid. It is functionally related to a nicotinic acid.
Synthesis
20826-04-4
24242-19-1
The general procedure for the synthesis of 5-aminonicotinic acid from 5-bromonicotinic acid was as follows: 5-bromo-3-pyridinecarboxylic acid (25 g, 0.124 mol) was mixed with ammonia (67.32 mL) and copper sulfate pentahydrate (8.41 g) was added. The reaction mixture was transferred to an autoclave, heated to 120 °C and kept for 16 hours. The reaction process was monitored by thin layer chromatography (TLC) using ninhydrin as a color developer. Upon completion of the reaction, the reaction mixture was washed with saturated sodium sulfide solution to remove copper ions, followed by adjusting the pH to 4-5 with concentrated hydrochloric acid.The acidified mixture was cooled to precipitate solids. The solid product was collected by filtration and dried to give 5-aminonicotinic acid (12.9 g, 74% yield).
References
[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6340 - 6350
[2] Patent: WO2004/35545, 2004, A2. Location in patent: Page 46
[3] Patent: WO2003/101959, 2003, A1. Location in patent: Page 50-51
[4] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1981, vol. 35, # 4, p. 289 - 294
[5] Journal of the American Chemical Society, 1948, vol. 70, p. 2381,2383
5-Aminonicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Aminonicotinic acid manufacturers
- Product
- 5-Aminonicotinic acid 24242-19-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-10-09
- Product
- 5-Aminonicotinic acid 24242-19-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 0.1KG
- Purity
- 98%
- Supply Ability
- 500KG/month
- Release date
- 2024-12-10
- Product
- 5-Ammonionicotinate 24242-19-1
- Price
- US $20.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-09-23