METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE

Product Name: METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE
CAS No.: 455-70-9
Chemical Name: METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE
Synonyms: Methyl5-fluoronicotinate;5-Fluoro-nicotinic acid methyl ester;METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE;Methyl 5-fluoro-3-pyridinecarboxylate;5-fluoro-2-methyl-3-pyridinecarboxylate;5-fluoro-3-pyridinecarboxylic acid methyl ester;5-Fluoropyridine-3-carboxylic acid methyl ester;3-Pyridinecarboxylic acid, 5-fluoro-, methyl ester;3-PYRIDINECARBONYL CHLORIDE, 5-FLUORO-, METHYL ESTER;METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE ISO 9001：2015 REACH
CBNumber: CB42446725
Molecular Formula: C7H6FNO2
Formula Weight: 155.13
MOL File: 455-70-9.mol

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METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE Property

Melting point:: 48 °C
Boiling point:: 194.5±25.0 °C(Predicted)
Density: 1.243±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: 0.77±0.20(Predicted)
Appearance: White to off-white Solid

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-37/39
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CDS020854
Product name: Methyl 5-fluoronicotinate
Packaging: 100mg
Price: $68.1
Updated: 2023/06/20

TRC

Product number: M305528
Product name: Methyl 5-fluoronicotinate
Packaging: 1g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC200409
Product name: Methyl5-fluoropyridine-3-carboxylate
Packaging: 1g
Price: $95
Updated: 2021/12/16

Matrix Scientific

Product number: 059070
Product name: 5-Fluoro-nicotinic acid methyl ester
Purity: 95%+
Packaging: 1g
Price: $95
Updated: 2021/12/16

Matrix Scientific

Product number: 059070
Product name: 5-Fluoro-nicotinic acid methyl ester
Purity: 95%+
Packaging: 5g
Price: $235
Updated: 2021/12/16

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METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

Methyl 5-fluoronicotinate

Synthesis

36052-25-2

455-70-9

Example 2.26: Synthesis of methyl 5-fluoronicotinate; To a stirring solution of 243 mg (1.6 mmol) of methyl 5-aminonicotinate dissolved in 5 mL of HF-pyridine at 0 °C was slowly added 119 mg (1.72 mmol) of sodium nitrite (NaNO2). The reaction mixture was stirred continuously at 0 °C for 30 min, then warmed up to 50 °C and kept for 1 hour. Upon completion of the reaction, the reaction was quenched with ice and saturated sodium bicarbonate (NaHCO3) solution. The aqueous phase was extracted with chloroform (CHCl3) and the organic phase was dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated. Purification by fast silica gel column chromatography (eluent: 1% methanol/chloroform) afforded 139 mg of methyl 5-fluoronicotinate as a yellow solid in 56% yield.

References

[1] Patent: WO2006/110668, 2006, A1. Location in patent: Page/Page column 62
[2] Journal of Organic Chemistry, 1949, vol. 14, p. 328,331
[3] Angewandte Chemie - International Edition, 2018, vol. 57, # 31, p. 9896 - 9900
[4] Angew. Chem., 2018, vol. 130, p. 10044 - 10048,5

METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

5-Aminonicotinic acid Isoamyl nitrite Sodium nitrite Fluoroboric acid Methanol Thionyl chloride

Preparation Products

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METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE Suppliers

China 73 Germany 1 India 1 United Kingdom 1 United States 10 Global 86

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
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Energy Chemical

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Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
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Tetranov Biopharm

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Nanjing Norris-Pharm Technology Co., Ltd

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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9ding chemical ( Shanghai) Limited

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SynAsst Chemical.

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Bide Pharmatech Ltd.

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Synchem OHG

Tel: +49 5662 408730
Fax: +49 5662 4087320
Email: info@synchem.de
Country: Germany
ProdList: 4705
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View Lastest Price from METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE 455-70-9
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-25

Career Henan Chemical Co

Product: METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE 455-70-9
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

455-70-9, METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATERelated Search:

2-Pyridinecarboxamide,5-fluoro-(9CI) 5-Fluoro-2-forMylpyridine 2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI) 3-FLUORO-5-FORMYLPYRIDINE 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE METHYL 2,6-DICHLORO-5-FLUORONICOTINATE 3-METHOXYPHENYL 2,6-DICHLORO-5-FLUORONICOTINATE Ethyl 2-chloro-5-fluoronicotinate ETHYL 5-FLUORONICOTINATE ethyl 2,6-dichloro-5-fluoropyridine-3-carboxylate 2-Butene-1,4-diol, bis(5-fluoronicotinate) 2,6-DIMETHYLPHENYL 2,6-DICHLORO-5-FLUORONICOTINATE METHYL2-CHLORO-5-FLUORONICOTINATE METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE PHENYL 2,6-DICHLORO-5-FLUORONICOTINATE

METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE

Methyl5-fluoronicotinate

5-Fluoropyridine-3-carboxylic acid methyl ester

5-Fluoro-nicotinic acid methyl ester

Methyl 5-fluoro-3-pyridinecarboxylate

3-Pyridinecarboxylic acid, 5-fluoro-, methyl ester

3-PYRIDINECARBONYL CHLORIDE, 5-FLUORO-, METHYL ESTER

5-fluoro-2-methyl-3-pyridinecarboxylate

5-fluoro-3-pyridinecarboxylic acid methyl ester

METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE ISO 9001：2015 REACH

455-70-9