5-Fluoro-2-forMylpyridine

Uses Application

Product Name: 5-Fluoro-2-forMylpyridine
CAS No.: 31181-88-1
Chemical Name: 5-Fluoro-2-forMylpyridine
Synonyms: 5-Fluoropiconaldehyde;5-fluoropicolinaldehyde;5-FLUORO-2-FORMYLPYRIDINE;5-Fluoro-2-pyridinecarbaldehyde;5-Fluoropyridine-2-carboxaldehyde;5-FLUORO-2-PYRIDINE CARBOXALDEHYDE;2-Pyridinecarboxaldehyde,5-fluoro-;2-Pyridinecarboxaldehyde,5-fluoro-(9CI);5-Fluoro-2-formylpyridine, 5-Fluoropicolinaldehyde
CBNumber: CB9292143
Molecular Formula: C6H4FNO
Formula Weight: 125.1
MOL File: 31181-88-1.mol

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5-Fluoro-2-forMylpyridine Property

Boiling point:: 174℃
Density: 1.269
Flash point:: 59℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.30±0.10(Predicted)
form: solid
color: White to yellow
InChI: InChI=1S/C6H4FNO/c7-5-1-2-6(4-9)8-3-5/h1-4H
InChIKey: IACCXWQKIQUVFQ-UHFFFAOYSA-N
SMILES: C1(C=O)=NC=C(F)C=C1

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
Hazard Note: Irritant
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: F532100
Product name: 5-Fluoro-2-formylpyridine
Packaging: 500mg
Price: $95
Updated: 2021/12/16

TRC

Product number: F532100
Product name: 5-Fluoro-2-formylpyridine
Packaging: 1g
Price: $155
Updated: 2021/12/16

Apolloscientific

Product number: PC7042
Product name: 5-Fluoropyridine-2-carboxaldehyde
Packaging: 1g
Price: $57
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: F1879
Product name: 5-Fluoro-2-formylpyridine
Purity: 98%
Packaging: 1g
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: Y5380
Product name: 5-Fluoropyridine-2-carboxaldehyde
Packaging: 1g
Price: $81
Updated: 2021/12/16

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5-Fluoro-2-forMylpyridine Chemical Properties,Usage,Production

Uses

5-Fluoropyridine-2-aldehyde is a pyridine derivative with diverse chemical reactivity. It can undergo aromatic nucleophilic substitution, condensation, addition and other chemical reactions, and is mainly used as an intermediate in organic synthesis and a raw material for pharmaceutical chemicals.

Application

5-Fluoropyridine-2-aldehyde exhibits high chemical reactivity and is mainly used as an intermediate in organic synthesis and a raw material in pharmaceutical chemistry. It has certain applications in the synthesis of pyridine-based functional organic molecules. For example, some literature reports that this substance can be used in the preparation of pyridine-based antimalarial compounds.

Synthesis

148541-70-2

31181-88-1

The general procedure for the synthesis of 5-fluoropyridine-2-carboxylic acid from ethyl 5-fluoropyridine-2-carboxylate is as follows: 5-fluoropyridine-2-carboxylic acid (200 mg, 1.13 mmol) was reacted with ethanol (6 mL) and a dioxane solution of 4M HCl (0.5 mL) for 20 hours at 90°C. After completion of the reaction, the mixture was concentrated and mixed with saturated sodium carbonate solution and dichloromethane. The organic layer was separated, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give ethyl 5-fluoropyridine-2-carboxylate (94 mg, 49.3% yield). Subsequently, ethyl 5-fluoropyridine-2-carboxylate (94 mg, 0.556 mmol) was dissolved in dichloromethane (4.0 mL) at room temperature, and a toluene solution of 1M DIBAL (1.23 mL, 1.23 mmol) was slowly added. The reaction mixture was stirred for 30 min, then the reaction was quenched with 2 M sodium carbonate solution and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product 5-fluoropyridine-2-carboxaldehyde (39 mg, 54.7% yield), which could be used directly in the subsequent reaction without further purification.GC-MS analysis showed a molecular ion peak (M+) of 125.

References

[1] Patent: WO2004/14902, 2004, A2. Location in patent: Page 42
[2] Patent: WO2009/58298, 2009, A1. Location in patent: Page/Page column 139
[3] Patent: WO2009/58299, 2009, A1. Location in patent: Page/Page column 55-56
[4] Patent: WO2010/111058, 2010, A1. Location in patent: Page/Page column 65
[5] Patent: WO2010/111059, 2010, A1. Location in patent: Page/Page column 50

5-Fluoro-2-forMylpyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Fluoro-2-forMylpyridine Suppliers

China 144 Europe 1 India 4 Italy 1 United Kingdom 2 United States 15 Global 167

Haisco Pharmaceutical Group Co., Ltd.

Tel: 028-6725-0449 19382244693
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J & K SCIENTIFIC LTD.

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Capot Chemical Co., Ltd

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Pure Chemistry Scientific Inc.

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ZEROSCHEM.CO.,LTD.

Tel: 10-61256048 13810278579
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Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
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Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
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View Lastest Price from 5-Fluoro-2-forMylpyridine manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Fluoropicolinaldehyde 31181-88-1
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-17

Shaanxi Dideu Medichem Co. Ltd

Product: 2-BROMO-3-FLUOROPYRIDINE 31181-88-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-26

Henan Aochuang Chemical Co.,Ltd.

Product: 5-Fluoro-2-forMylpyridine 31181-88-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-19

31181-88-1, 5-Fluoro-2-forMylpyridineRelated Search:

2-Pyridinecarboxamide,5-fluoro-(9CI) 2-Pyridinecarboxylicacid,5-fluoro-,methylester(9CI) METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE 3-FLUORO-5-FORMYLPYRIDINE 3-FLUORO-5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)PYRIDINE 3-Fluoropyridine 3-FLUORO-2-FORMYLPYRIDINE 5-FLUORO-2-PICOLINIC ACID 3,5-Difluoropicolinic acid 5,6-Difluoro-4-(trimethylsilyl)pyridine-2-carboxylic acid 5,6-Difluoropyridine-2-carboxylic acid 5-Fluoro-2-forMylpyridine 3-FLUORO-6-FORMYL-2-PICOLINE 5-FLUORO-6-METHYLPYRIDINE-2-CARBOXYLIC ACID 3,5-DIFLUOROPYRIDINE-2-CARBOXAMIDE 3-BROMO-5-FLUORO-6-METHOXYPYRIDINE-2-CARBOXAMIDE 6-ACETYL-5-FLUOROPYRIDINE-2-CARBOXAMIDE

5-FLUORO-2-FORMYLPYRIDINE

5-FLUORO-2-PYRIDINE CARBOXALDEHYDE

5-Fluoropyridine-2-carboxaldehyde

2-Pyridinecarboxaldehyde,5-fluoro-(9CI)

2-Pyridinecarboxaldehyde,5-fluoro-

5-fluoropicolinaldehyde

5-Fluoro-2-formylpyridine, 5-Fluoropicolinaldehyde

5-Fluoropiconaldehyde

5-Fluoro-2-pyridinecarbaldehyde

31181-88-1

31189-88-1

Aldehyde

Building Blocks

PYRIDINE

pharmacetical