3-FLUORO-2-FORMYLPYRIDINE
- Product Name
- 3-FLUORO-2-FORMYLPYRIDINE
- CAS No.
- 31224-43-8
- Chemical Name
- 3-FLUORO-2-FORMYLPYRIDINE
- Synonyms
- uoropyridine-2-carbaL;3-fluoropicolinaldehyde;3-FLURO-2-FORMYLPYRIDINE;3-FLUORO-2-FORMYLPYRIDINE;3-FLUORO-2-FORMYLPYRIDINE ,98%;3-FLUOROPYRIDINE-2-CARBALDEHYDE;3-Fluoro-2-pyridinecarboxaldehyde;3-FLUOROPYRIDINE-2-CARBOXALDEHYDE;2-Pyridinecarboxaldehyde, 3-fluoro-;3-fluoro-2-formylpyridine FP161123
- CBNumber
- CB3461183
- Molecular Formula
- C6H4FNO
- Formula Weight
- 125.1
- MOL File
- 31224-43-8.mol
3-FLUORO-2-FORMYLPYRIDINE Property
- Melting point:
- 49 °C
- Boiling point:
- 112°C/50mmHg(lit.)
- Density
- 1.269±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- Solid
- pka
- 1.25±0.10(Predicted)
- color
- White to Green to Brown
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H4FNO/c7-5-2-1-3-8-6(5)4-9/h1-4H
- InChIKey
- OZIMPUNGBUYCSP-UHFFFAOYSA-N
- SMILES
- C1(C=O)=NC=CC=C1F
- CAS DataBase Reference
- 31224-43-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0975
- Product name
- 3-Fluoro-2-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $24
- Updated
- 2025/07/31
- Product number
- F0975
- Product name
- 3-Fluoro-2-pyridinecarboxaldehyde
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $67
- Updated
- 2025/07/31
- Product number
- F596250
- Product name
- 3-Fluoro-2-pyridinecarboxaldehyde
- Packaging
- 5g
- Price
- $365
- Updated
- 2021/12/16
- Product number
- F1799
- Product name
- 3-Fluoro-2-formylpyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $12
- Updated
- 2021/12/16
- Product number
- F1799
- Product name
- 3-Fluoro-2-formylpyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
3-FLUORO-2-FORMYLPYRIDINE Chemical Properties,Usage,Production
Uses
3-Fluoropyridine-2-carboxaldehyde is used to prepare taxoids derived from 9β-dihydrobaccatin-9,10-acetals with anti-tumor activities. It is also an intermediate used to synthesize S-3578 derivatives with potent activities against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa.
Synthesis Reference(s)
Tetrahedron, 39, p. 2009, 1983 DOI: 10.1016/S0040-4020(01)91919-2
Synthesis
372-47-4
68-12-2
31224-43-8
To a solution of DABCO (8.8 g, 78.2 mmol) in anhydrous ether (250 mL) was slowly added n-BuLi (1.6 M hexane solution, 49 mL, 78.2 mmol) at -25 °C. The reaction mixture was stirred between -25 and -10°C for 45 minutes and subsequently cooled to -70°C. At -70 °C, 3-fluoropyridine (5.9 mL, 71 mmol) was added dropwise to the above reaction solution. The reaction temperature was maintained between -70 and -60 °C and stirring was continued for 1.5 hours. After that, DMF (11.0 mL, 2.0 eq.) was added to the reaction system. After stirring at -70 °C for 1.0 h, the reaction was quenched by slow addition of water (150 mL) and gradually warmed to room temperature. Upon completion of the reaction, the organic and aqueous layers were separated and the aqueous layer was extracted with dichloromethane (5 x 100 mL). All organic layers were combined, washed with saturated saline and dried with anhydrous sodium sulfate. After the solvent was removed by concentration under reduced pressure, the crude product was purified by silica gel column chromatography using ethyl acetate/hexane gradient elution to afford 3-fluoropyridine-2-aldehyde (5.4 g, 55-60% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.54-7.57 (m, 2H), 8.61 (d, J = 2.20 Hz, 1H), 10.20 (s, 1H).
References
[1] Patent: US2010/227894, 2010, A1. Location in patent: Page/Page column 55
[2] Patent: WO2006/114706, 2006, A1. Location in patent: Page/Page column 47-48
[3] Tetrahedron, 1983, vol. 39, # 12, p. 2009 - 2021
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 23, p. 6998 - 7003
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 6, p. 1852 - 1856
3-FLUORO-2-FORMYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
3-FLUORO-2-FORMYLPYRIDINE Suppliers
- Tel
- 0319-5801333-8008 15630992918
- sales@summedchem.com
- Country
- China
- ProdList
- 972
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 025-86918202 4000255188
- Fax
- 86-025-86918232
- sales@pharmablock.com
- Country
- China
- ProdList
- 5000
- Advantage
- 55
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- +86-21-54098501
- Fax
- +86-21-54096319
- sales@sinch.com.cn
- Country
- China
- ProdList
- 11598
- Advantage
- 64
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
View Lastest Price from 3-FLUORO-2-FORMYLPYRIDINE manufacturers
- Product
- 3-FLUORO-2-FORMYLPYRIDINE 31224-43-8
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100 mt
- Release date
- 2024-11-28
- Product
- 3-FLUORO-2-FORMYLPYRIDINE 31224-43-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 3-FLUORO-2-FORMYLPYRIDINE 31224-43-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-20