4-IODO-2-FLUORO-3-FORMYLPYRIDINE
Application- Product Name
- 4-IODO-2-FLUORO-3-FORMYLPYRIDINE
- CAS No.
- 153034-82-3
- Chemical Name
- 4-IODO-2-FLUORO-3-FORMYLPYRIDINE
- Synonyms
- 2-fluoro-4-iodonicotaldehyde;2-FLUORO-4-IODONICOTINALDEHYDE;2-FLUORO-3-FORMYL-4-IODOPYRIDINE;4-IODO-2-FLUORO-3-FORMYLPYRIDINE;2-fluoro-4-iodo3-aldehyde pyridine;2-Fluoro-4-iodopyridine-3-carbaldehyde;2-FLUORO-4-IODOPYRIDINE-3-CARBOXALDEHYDE;2 - F -3 - aldehyde -4 - iodine pyridine;2-Fluoro-4-iodo-3-pyridinecarboxaldehyde;2-fluoro-4-iodo-3-pyridinecarboxyaldehyde
- CBNumber
- CB2415952
- Molecular Formula
- C6H3FINO
- Formula Weight
- 251
- MOL File
- 153034-82-3.mol
4-IODO-2-FLUORO-3-FORMYLPYRIDINE Property
- Boiling point:
- 304.2±42.0 °C(Predicted)
- Density
- 2.081±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- solid
- pka
- -3.62±0.18(Predicted)
- color
- Yellow
- InChI
- InChI=1S/C6H3FINO/c7-6-4(3-10)5(8)1-2-9-6/h1-3H
- InChIKey
- VONGIOGTLFSXDE-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=CC(I)=C1C=O
- CAS DataBase Reference
- 153034-82-3(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SYX00351
- Product name
- 2-Fluoro-3-formyl-4-iodopyridine
- Packaging
- 1g
- Price
- $216
- Updated
- 2025/07/31
- Product number
- F401418
- Product name
- 2-Fluoro-4-iodonicotinaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 070789
- Product name
- 2-Fluoro-4-iodopyridine-3-carbaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $78
- Updated
- 2021/12/16
- Product number
- PC8525
- Product name
- 2-Fluoro-4-iodonicotinaldehyde
- Packaging
- 5g
- Price
- $109
- Updated
- 2021/12/16
- Product number
- N393
- Product name
- 2-Fluoro-4-iodonicotinaldehyde
- Packaging
- 1g
- Price
- $41
- Updated
- 2021/12/16
4-IODO-2-FLUORO-3-FORMYLPYRIDINE Chemical Properties,Usage,Production
Application
2-Fluoro-3-aldehyde-4-iodopyridine is a heterocyclic organic compound that can be used as a pharmaceutical synthesis intermediate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 58, p. 7832, 1993 DOI: 10.1021/jo00079a031
Synthesis
113975-22-7
109-94-4
153034-82-3
To a solution of diisopropylamine (174.4 g, 1.73 mol) in anhydrous THF (3 L) was added slowly and dropwise 2.5 M hexane solution of n-butyllithium (n-BuLi) (685 mL, 1.71 mol) at -10 °C. The reaction mixture was stirred at 0 °C for 35 min. Subsequently, the mixture was cooled to -70 °C and a solution of anhydrous THF (1 L) of 2-fluoro-3-iodopyridine (350 g, 1.57 mol) was added. The mixture was continued to be stirred at -70 °C for 2 hours. Ethyl formate (HCOOEt) (128 g, 1.73 mol) was slowly added dropwise while maintaining -70 °C. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and the reaction was quenched with ice water (4 L). The reaction mixture was diluted with ethyl acetate (EtOAc) (4 L) and the organic layer was washed with brine (500 mL). The organic layer was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent being petroleum ether: ethyl acetate (10:1, v/v) to afford the target product 2-fluoro-4-iodopyridine-3-carbaldehyde (180 g, 46% yield) as a yellow solid.1H NMR (400 MHz, CDCl3) δ ppm: 10.08 (s, 1H), 7.91 (d, 1H), 7.81 (d, 1H). 1H).
References
[1] Journal of Organic Chemistry, 1993, vol. 58, # 27, p. 7832 - 7838
[2] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 58
4-IODO-2-FLUORO-3-FORMYLPYRIDINE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 4-IODO-2-FLUORO-3-FORMYLPYRIDINE manufacturers
- Product
- 4-IODO-2-FLUORO-3-FORMYLPYRIDINE 153034-82-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 4-IODO-2-FLUORO-3-FORMYLPYRIDINE 153034-82-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- 4-IODO-2-FLUORO-3-FORMYLPYRIDINE 153034-82-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14