2-Fluoro-4-iodopyridine
- Product Name
- 2-Fluoro-4-iodopyridine
- CAS No.
- 22282-70-8
- Chemical Name
- 2-Fluoro-4-iodopyridine
- Synonyms
- 4-Iodo-2-fluoropyridine;uoro-4-iodopyridine;2-Fluor-4-iodopyridine;2-FLUORO-4-IODOPYRIDINE;Pyridine, 2-fluoro-4-iodo-;2-Fluoro-4-iodopyridine>2-Fluoro-4-iodopyridine AldrichCPR;2-Fluoro-4-iodopyridine ISO 9001：2015 REACH
- CBNumber
- CB6361327
- Molecular Formula
- C5H3FIN
- Formula Weight
- 222.99
- MOL File
- 22282-70-8.mol
2-Fluoro-4-iodopyridine Property
- Melting point:
- 57 °C
- Boiling point:
- 223.0±20.0 °C(Predicted)
- Density
- 2.046±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- -1.81±0.10(Predicted)
- color
- White to Light yellow
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C5H3FIN/c6-5-3-4(7)1-2-8-5/h1-3H
- InChIKey
- ADPRIAVYIGHFSO-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=CC(I)=C1
- CAS DataBase Reference
- 22282-70-8(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-22
- Safety Statements
- 22-26-36/37/39
- Hazard Note
- Harmful
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- F0773
- Product name
- 2-Fluoro-4-iodopyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $39
- Updated
- 2025/07/31
- Product number
- F0773
- Product name
- 2-Fluoro-4-iodopyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $150
- Updated
- 2025/07/31
- Product number
- F598833
- Product name
- 2-Fluoro-4-iodopyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- F598833
- Product name
- 2-Fluoro-4-iodopyridine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- F13005
- Product name
- 2-Fluoro-4-iodopyridine
- Packaging
- 25g
- Price
- $74
- Updated
- 2021/12/16
2-Fluoro-4-iodopyridine Chemical Properties,Usage,Production
Chemical Properties
Salmon-coloured solid
Synthesis
113975-22-7
22282-70-8
The general procedure for the synthesis of 2-fluoro-4-iodopyridine from 2-fluoro-3-iodopyridine was as follows: to a solution of 2-fluoro-3-iodopyridine (4.0 g, 17.9 mmol) in anhydrous THF (50 mL) was added slowly and dropwise to LDA (8.96 mL, 2 M THF solution, 17.9 mmol) at -78°C. After the reaction mixture was stirred at -78°C for 4 h, a THF (1 mL) solution of H2O (0.5 mL) was added. Subsequently, the reaction mixture was slowly warmed to room temperature and quenched by the addition of brine (30 mL). The organic layer was separated, washed with brine, dried over anhydrous Na2SO4 and concentrated to give the crude product. The crude product was purified by column chromatography to give 2-fluoro-4-iodopyridine (3.5 g, yield: 87.5%) as a white solid.LC/MS analysis showed m/z (M++H)=224.
References
[1] Organic and Biomolecular Chemistry, 2006, vol. 4, # 10, p. 1927 - 1948
[2] Journal of Organic Chemistry, 1993, vol. 58, # 27, p. 7832 - 7838
[3] Patent: WO2004/76424, 2004, A1. Location in patent: Page 85
[4] Patent: EP1559320, 2005, A1. Location in patent: Page/Page column 6
[5] Patent: WO2013/6792, 2013, A1. Location in patent: Paragraph 0189
2-Fluoro-4-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-4-iodopyridine manufacturers
- Product
- 2-Fluoro-4-iodopyridine 22282-70-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13
- Product
- 2-Fluoro-4-iodopyridine 22282-70-8
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 2-Fluoro-4-iodopyridine 22282-70-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01