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ChemicalBook > CAS DataBase List > 4-IODO-2-FLUORO-3-FORMYLPYRIDINE

4-IODO-2-FLUORO-3-FORMYLPYRIDINE

Application
Product Name
4-IODO-2-FLUORO-3-FORMYLPYRIDINE
CAS No.
153034-82-3
Chemical Name
4-IODO-2-FLUORO-3-FORMYLPYRIDINE
Synonyms
2-fluoro-4-iodonicotaldehyde;2-FLUORO-4-IODONICOTINALDEHYDE;2-FLUORO-3-FORMYL-4-IODOPYRIDINE;4-IODO-2-FLUORO-3-FORMYLPYRIDINE;2-fluoro-4-iodo3-aldehyde pyridine;2-Fluoro-4-iodopyridine-3-carbaldehyde;2-FLUORO-4-IODOPYRIDINE-3-CARBOXALDEHYDE;2 - F -3 - aldehyde -4 - iodine pyridine;2-Fluoro-4-iodo-3-pyridinecarboxaldehyde;2-fluoro-4-iodo-3-pyridinecarboxyaldehyde
CBNumber
CB2415952
Molecular Formula
C6H3FINO
Formula Weight
251
MOL File
153034-82-3.mol
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4-IODO-2-FLUORO-3-FORMYLPYRIDINE Property

Boiling point:
304.2±42.0 °C(Predicted)
Density 
2.081±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form 
solid
pka
-3.62±0.18(Predicted)
color 
Yellow
InChI
InChI=1S/C6H3FINO/c7-6-4(3-10)5(8)1-2-9-6/h1-3H
InChIKey
VONGIOGTLFSXDE-UHFFFAOYSA-N
SMILES
C1(F)=NC=CC(I)=C1C=O
CAS DataBase Reference
153034-82-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22
Hazard Note 
Irritant
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SYX00351
Product name
2-Fluoro-3-formyl-4-iodopyridine
Packaging
1g
Price
$216
Updated
2025/07/31
TRC
Product number
F401418
Product name
2-Fluoro-4-iodonicotinaldehyde
Packaging
100mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
070789
Product name
2-Fluoro-4-iodopyridine-3-carbaldehyde
Purity
95+%
Packaging
1g
Price
$78
Updated
2021/12/16
Apolloscientific
Product number
PC8525
Product name
2-Fluoro-4-iodonicotinaldehyde
Packaging
5g
Price
$109
Updated
2021/12/16
AK Scientific
Product number
N393
Product name
2-Fluoro-4-iodonicotinaldehyde
Packaging
1g
Price
$41
Updated
2021/12/16
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4-IODO-2-FLUORO-3-FORMYLPYRIDINE Chemical Properties,Usage,Production

Application

2-Fluoro-3-aldehyde-4-iodopyridine is a heterocyclic organic compound that can be used as a pharmaceutical synthesis intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 58, p. 7832, 1993 DOI: 10.1021/jo00079a031

Synthesis

113975-22-7

109-94-4

153034-82-3

To a solution of diisopropylamine (174.4 g, 1.73 mol) in anhydrous THF (3 L) was added slowly and dropwise 2.5 M hexane solution of n-butyllithium (n-BuLi) (685 mL, 1.71 mol) at -10 °C. The reaction mixture was stirred at 0 °C for 35 min. Subsequently, the mixture was cooled to -70 °C and a solution of anhydrous THF (1 L) of 2-fluoro-3-iodopyridine (350 g, 1.57 mol) was added. The mixture was continued to be stirred at -70 °C for 2 hours. Ethyl formate (HCOOEt) (128 g, 1.73 mol) was slowly added dropwise while maintaining -70 °C. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and the reaction was quenched with ice water (4 L). The reaction mixture was diluted with ethyl acetate (EtOAc) (4 L) and the organic layer was washed with brine (500 mL). The organic layer was dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent being petroleum ether: ethyl acetate (10:1, v/v) to afford the target product 2-fluoro-4-iodopyridine-3-carbaldehyde (180 g, 46% yield) as a yellow solid.1H NMR (400 MHz, CDCl3) δ ppm: 10.08 (s, 1H), 7.91 (d, 1H), 7.81 (d, 1H). 1H).

References

[1] Journal of Organic Chemistry, 1993, vol. 58, # 27, p. 7832 - 7838
[2] Patent: WO2016/97918, 2016, A1. Location in patent: Page/Page column 58

4-IODO-2-FLUORO-3-FORMYLPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-IODO-2-FLUORO-3-FORMYLPYRIDINE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-IODO-2-FLUORO-3-FORMYLPYRIDINE 153034-82-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1Ton
Release date
2022-10-13
Dideu Industries Group Limited
Product
4-IODO-2-FLUORO-3-FORMYLPYRIDINE 153034-82-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-01
Career Henan Chemical Co
Product
4-IODO-2-FLUORO-3-FORMYLPYRIDINE 153034-82-3
Price
US $1.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Customized
Release date
2018-12-14

153034-82-3, 4-IODO-2-FLUORO-3-FORMYLPYRIDINERelated Search:

2-Fluoro-4-iodopyridine 2-Fluoro-3-iodopyridine 2-Fluoro-3-methylpyridine 4-IODO-2-FLUORO-3-FORMYLPYRIDINE 2-FLUORO-4-IODO-3-PICOLINE 4-Iodopyridine 4-Iodo-3-methylpyridine 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER 2-FLUORO-4-IODONICOTINIC ACID 2-FLUORO-3-FORMYLPYRIDINE

  • 2-FLUORO-4-IODONICOTINALDEHYDE
  • 2-FLUORO-4-IODOPYRIDINE-3-CARBOXALDEHYDE
  • 4-IODO-2-FLUORO-3-FORMYLPYRIDINE
  • 2-fluoro-4-iodonicotaldehyde
  • 2-FLUORO-3-FORMYL-4-IODOPYRIDINE
  • 2-Fluoro-4-iodo-3-pyridinecarboxaldehyde
  • 2 - F -3 - aldehyde -4 - iodine pyridine
  • 2-Fluoro-4-iodopyridine-3-carbaldehyde
  • 2-Fluoro-4-iodopyridine-3-carboxaldehyde, 2-Fluoro-3-formyl-4-iodopyridine
  • 2-fluoro-4-iodo-3-pyridinecarboxyaldehyde
  • 3-Pyridinecarboxaldehyde, 2-fluoro-4-iodo-
  • [(fluoro-2-iodo-4)pyrid-3-yl]-carboxaldehyde
  • 4-IODO-2-FLUORO-3-FORMYLPYRIDINE ISO 9001：2015 REACH
  • 2-fluoro-4-iodo3-aldehyde pyridine
  • 153034-82-3
  • C6H3FINO
  • Fluorine series
  • Pyridines
  • Pyridine