2-FLUORO-3-FORMYLPYRIDINE
- Product Name
- 2-FLUORO-3-FORMYLPYRIDINE
- CAS No.
- 36404-90-7
- Chemical Name
- 2-FLUORO-3-FORMYLPYRIDINE
- Synonyms
- 2-FLUORONICOTINALDEHYDE;3-Pyridine;-FLUORO-3-FORMYLPYRIDINE;2-FLUORO-3-FORMYLPYRIDINE;2-fluoro-3-aldehyde pyridine;2-FLUOROPYRIDINE-3-CARBALDEHYDE;2-Fluoro-pyridin-3-carbaldehyde;2-FLUOROPYRIDINE-3-CARBOXALDEHYDE;2-FLUORO-3-PYRIDINECARBOXALDEHYDE;2-Fluoropyridine-3-carboxyaldehyde
- CBNumber
- CB3473973
- Molecular Formula
- C6H4FNO
- Formula Weight
- 125.1
- MOL File
- 36404-90-7.mol
2-FLUORO-3-FORMYLPYRIDINE Property
- Boiling point:
- 50 °C/3 mmHg
- Density
- 1.250 g/mL at 25 °C
- refractive index
- n20/D 1.520
- Flash point:
- 164 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- -2.23±0.10(Predicted)
- form
- liquid
- color
- Clear, dark yellow
- InChIKey
- OFBVGDCXXGXDKU-UHFFFAOYSA-N
- CAS DataBase Reference
- 36404-90-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F1266
- Product name
- 2-Fluoro-3-formylpyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
- Product number
- F1266
- Product name
- 2-Fluoro-3-formylpyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $35
- Updated
- 2021/12/16
- Product number
- N385
- Product name
- 2-Fluoropyridine-3-carboxaldehyde
- Packaging
- 5g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- PC7036
- Product name
- 2-Fluoronicotinaldehyde
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- N385
- Product name
- 2-Fluoropyridine-3-carboxaldehyde
- Packaging
- 10g
- Price
- $91
- Updated
- 2021/12/16
2-FLUORO-3-FORMYLPYRIDINE Chemical Properties,Usage,Production
Uses
Attachment of isoxazolinones by displacement of fluoride provide naphthyridines on hydrogenolysis and cyclization.
Synthesis
2591-86-8
372-48-5
36404-90-7
GENERAL STEPS: Lithium (trimethylsilylmethyl) (22 mL, 13.8 wt% hexane solution) was added to a 100 mL three-necked round-bottomed flask and the reaction system cooled to -50 °C. A mixed solution containing 2-fluoropyridine (2.0 g), THF (25 mL), and diisopropylamine (0.13 mL) was slowly added over 1 min while keeping the temperature below -50 °C. After 3 hours of reaction, 1-formylpiperidine (2.4 g) was added over 1 min, also at below -50 °C. Subsequently, the reaction mixture was gradually warmed to room temperature and stirring was continued overnight. Upon completion of the reaction, the reaction was quenched with acetic acid (3 mL) and water (7 mL). The aqueous layer was separated and washed with methyl tert-butyl ether (MTBE, 3 x 25 mL). All organic layers were combined, dried with anhydrous magnesium sulfate (MgSO?) and concentrated under reduced pressure to give 3.79 g of brown oil. Finally, the oily material was purified by silica gel column chromatography, using a hexane solution of 15% ethyl acetate as eluent, to give 2.24 g of 2-fluoro-3-pyridinecarboxaldehyde with a purity of 92.4% (90% yield, corrected for assay).
References
[1] Patent: WO2004/92125, 2004, A2. Location in patent: Page 7-8
[2] Journal of Organometallic Chemistry, 1991, vol. 406, # 1+2, p. 49 - 56
2-FLUORO-3-FORMYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
2-FLUORO-3-FORMYLPYRIDINE Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 0418-6530555 2855550
- Fax
- +86-418-6502885
- Country
- China
- ProdList
- 338
- Advantage
- 69
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10186
- Advantage
- 62
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18729
- Advantage
- 57
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 022-58013646 13011382049
- Fax
- 022-23854368
- sales@jinyudachem.com
- Country
- China
- ProdList
- 1930
- Advantage
- 55
View Lastest Price from 2-FLUORO-3-FORMYLPYRIDINE manufacturers
- Product
- 2-FLUORO-3-FORMYLPYRIDINE 36404-90-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 2-FLUORO-3-FORMYLPYRIDINE 36404-90-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-14