2,6-DIFLUORONICOTINALDEHYDE
Application- Product Name
- 2,6-DIFLUORONICOTINALDEHYDE
- CAS No.
- 155601-65-3
- Chemical Name
- 2,6-DIFLUORONICOTINALDEHYDE
- Synonyms
- 2,6-DIFLUORONICOTINALDEHYDE;2,6-Difluoro-3-nicotinaldehyde;2,6-Difluoronicotinaldehyde 97%;2,6-Difluoro-pyridin-3-carbaldehyde;2,6-DIFLUOROPYRIDINE-3-CARBALDEHYDE;2,6-Difluoropyridine-3-carboxaldehyd;2,6-Difluoropyridine-3-carboxaldehyde;2,6-difluoro-3-Pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde,2,6-difluoro-;2,6-Difluoropyridine-3-carboxaldehyde,95%
- CBNumber
- CB6252140
- Molecular Formula
- C6H3F2NO
- Formula Weight
- 143.09
- MOL File
- 155601-65-3.mol
2,6-DIFLUORONICOTINALDEHYDE Property
- Melting point:
- 19-20℃
- Boiling point:
- 64-66℃/15mm
- Density
- 1.378
- refractive index
- 1.4920
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- form
- Liquid
- pka
- -7.89±0.10(Predicted)
- Appearance
- Colorless to light yellow <19°C Solid,>20°C Liquid
- Sensitive
- Moisture Sensitive
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT, KEEP COLD, STORED UNDER ARGON
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D447763
- Product name
- 2,6-Difluoronicotinaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC7981
- Product name
- 2,6-Difluoronicotinaldehyde
- Purity
- 97%
- Packaging
- 5g
- Price
- $41
- Updated
- 2021/12/16
- Product number
- 4H15-3-Y0
- Product name
- 2,6-Difluoro-3-nicotinaldehyde
- Purity
- 97%
- Packaging
- 5G
- Price
- $66
- Updated
- 2021/12/16
- Product number
- Y7649
- Product name
- 2,6-Difluoropyridine-3-carbaldehyde
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
- Product number
- Y7649
- Product name
- 2,6-Difluoropyridine-3-carbaldehyde
- Packaging
- 5g
- Price
- $125
- Updated
- 2021/12/16
2,6-DIFLUORONICOTINALDEHYDE Chemical Properties,Usage,Production
Application
2,6-Difluoropyridine-3-carboxaldehyde can be used as a pharmaceutical synthesis intermediate, prepared by formylation of 2,6-difluoropyridine as a reactant. Some literature reports its potential use as an additive in battery electrolytes.
Synthesis
2591-86-8
1513-65-1
155601-65-3
A solution of 2,6-difluoropyridine (4.95 g, 43.0 mmol) in anhydrous tetrahydrofuran (100 mL) was cooled to -78 °C under nitrogen atmosphere and lithium diisopropylammonium (2.0 M in heptane/tetrahydrofuran/ethylbenzene, 23.0 mL, 46.0 mmol) was added slowly. The reaction mixture was stirred at -78 °C for 30 min before N-formylpiperidine (4.98 g, 44.0 mmol) was added. Stirring was continued at -78 °C for 20 min, followed by the addition of 3 N hydrochloric acid aqueous solution (60 mL) and ether (50 mL). The ether layer was separated and the aqueous layer was extracted with ether (3 x 100 mL). The organic phases were combined and dried over anhydrous sodium sulfate. After filtration, the solvent was removed under reduced pressure and the residue was purified by rapid column chromatography on silica gel (dichloromethane/hexane, 1:1 v/v) to afford 2,6-difluoropyridine-3-carboxaldehyde as a pale yellow liquid (1.41 g, 60% yield).
References
[1] Patent: WO2007/22371, 2007, A2. Location in patent: Page/Page column 61
2,6-DIFLUORONICOTINALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-DIFLUORONICOTINALDEHYDE manufacturers
- Product
- 2,6-DIFLUORONICOTINALDEHYDE 155601-65-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 2,6-DIFLUORONICOTINALDEHYDE 155601-65-3
- Price
- US $10.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-28
- Product
- 2,6-DIFLUORONICOTINALDEHYDE 155601-65-3
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-19