2,6-Difluoropyridine
- Product Name
- 2,6-Difluoropyridine
- CAS No.
- 1513-65-1
- Chemical Name
- 2,6-Difluoropyridine
- Synonyms
- 2,6-DifL;2,6-Difluorpyridin;2,6-difluoropyridi;2,6-DIFLUOROPYRIDINE;2,6-Difuloropyridine;Pyridine, 2,6-difluoro-;2,6-Difluoropyridine99%;2,6-Difluoropyridine 99%;2, 6-2 fluoride pyridine;2,6-Difluoropyridine >
- CBNumber
- CB6210492
- Molecular Formula
- C5H3F2N
- Formula Weight
- 115.08
- MOL File
- 1513-65-1.mol
2,6-Difluoropyridine Property
- Boiling point:
- 124.5 °C/743 mmHg (lit.)
- Density
- 1.268 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.437(lit.)
- Flash point:
- 93 °F
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Not miscible or difficult to mix.
- form
- Liquid
- pka
- -6.09±0.10(Predicted)
- Specific Gravity
- 1.268
- color
- Clear purple-red
- BRN
- 1422549
- Dielectric constant
- 107.8
- InChIKey
- MBTGBRYMJKYYOE-UHFFFAOYSA-N
- CAS DataBase Reference
- 1513-65-1(CAS DataBase Reference)
- NIST Chemistry Reference
- 2,6-Difluoropyridine(1513-65-1)
Safety
- Hazard Codes
- Xi,T,F
- Risk Statements
- 10-36/37/38
- Safety Statements
- 16-26-36/37/39-37/39
- RIDADR
- UN 1993 3/PG 3
- WGK Germany
- 3
- F
- 10
- Hazard Note
- Toxic
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29333999
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 233277
- Product name
- 2,6-Difluoropyridine
- Purity
- 99%
- Packaging
- 5g
- Price
- $48.3
- Updated
- 2025/07/31
- Product number
- 233277
- Product name
- 2,6-Difluoropyridine
- Purity
- 99%
- Packaging
- 25g
- Price
- $116.68
- Updated
- 2025/07/31
- Product number
- D1741
- Product name
- 2,6-Difluoropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $40
- Updated
- 2025/07/31
- Product number
- D1741
- Product name
- 2,6-Difluoropyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $112
- Updated
- 2025/07/31
- Product number
- D447748
- Product name
- 2,6-Difluoropyridine
- Packaging
- 500mg
- Price
- $45
- Updated
- 2021/12/16
2,6-Difluoropyridine Chemical Properties,Usage,Production
Chemical Properties
Colorless to light yellow liquid
Uses
2,6-Difluoropyridine has been used in the preparation of poly(pyridine ether)s via polycondensation with silylated 1,1,1-tris(4-hydroxyphenyl)ethane.
General Description
Lithium diisopropylamide (LDA)-mediated ortholithiations of 2,6-difluoropyridine in tetrahydrofuran at -78°C has been studied using a combination of IR and NMR spectroscopic and computational methods. Polycondensation of bistrimethylsilyl derivatives of various diphenols with 2,6-difluoropyridine in N-methylpyrrolidone in the presence of K2CO3 has been investigated.
Synthesis
2402-78-0
1513-65-1
General procedure for the synthesis of 2,6-difluoropyridine from 2,6-dichloropyridine: In a desiccator, accurately weigh anhydrous NMe4F (18.6 mg, 0.2 mmol, 2 eq.) and 2,6-dichloropyridine (0.1 mmol, 1 eq.) in a 4 mL vial fitted with a microstirring bar. DMF (0.5 mL) was added, the vial was removed from the desiccator, and the reaction was stirred at room temperature for 24 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and the internal standard (1,3,5-trifluorobenzene, 100 μL 0.5 M toluene solution) was added. Aliquots were taken for 59F NMR spectroscopy and GC-MS analysis.
References
[1] Patent: US4071521, 1978, A
[2] Angewandte Chemie - International Edition, 2006, vol. 45, # 17, p. 2720 - 2725
[3] Organic Letters, 2015, vol. 17, # 8, p. 1866 - 1869
[4] Journal of Organic Chemistry, 2015, vol. 80, # 24, p. 12137 - 12145
[5] Patent: WO2017/24167, 2017, A1. Location in patent: Page/Page column 29; 33; 35
2,6-Difluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Difluoropyridine manufacturers
- Product
- 2,6-Difluoropyridine 1513-65-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 2,6-Difluoropyridine 1513-65-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28
- Product
- 2,6-Difluoropyridine 1513-65-1
- Price
- US $8.00-0.80/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-01-22