2,6-Difluoro-3-iodopyridine
- Product Name
- 2,6-Difluoro-3-iodopyridine
- CAS No.
- 685517-67-3
- Chemical Name
- 2,6-Difluoro-3-iodopyridine
- Synonyms
- 3-Iodo-2,6-difluoropyridine;2,6-Difluoro-3-iodopyridine;Pyridine,2,6-difluoro-3-iodo-
- CBNumber
- CB51107275
- Molecular Formula
- C5H2F2IN
- Formula Weight
- 240.98
- MOL File
- 685517-67-3.mol
2,6-Difluoro-3-iodopyridine Property
- Melting point:
- 38.0 to 42.0 °C
- Boiling point:
- 230.1±35.0 °C(Predicted)
- Density
- 2.129±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- soluble in Methanol
- form
- powder to lump
- pka
- -8.11±0.10(Predicted)
- color
- White to Light yellow
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D5141
- Product name
- 2,6-Difluoro-3-iodopyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $56
- Updated
- 2025/07/31
- Product number
- D5141
- Product name
- 2,6-Difluoro-3-iodopyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $222
- Updated
- 2025/07/31
- Product number
- D445823
- Product name
- 2,6-Difluoro-3-iodopyridine
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- D445823
- Product name
- 2,6-Difluoro-3-iodopyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC7983
- Product name
- 2,6-Difluoro-3-iodopyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $46
- Updated
- 2021/12/16
2,6-Difluoro-3-iodopyridine Chemical Properties,Usage,Production
Synthesis
1513-65-1
685517-67-3
General procedure for the synthesis of 2,6-difluoro-3-iodopyridine from 2,6-difluoropyridine: 2,6-difluoropyridine (1.15 g, 10 mmol) was dissolved in toluene (300 ml) at -78 °C and under nitrogen protection, and n-butyllithium (n-BuLi, 4.8 ml, 12 mmol, 1.2 eq.) was slowly added. The reaction mixture was stirred continuously at -78 °C for 4 hours. Subsequently, iodine (2.53 g, 10 mmol) was added while the temperature was kept below -70 °C. The reaction mixture was gradually warmed up to room temperature and the reaction was quenched with 10 ml of water. The organic solvent was removed by distillation under reduced pressure and the residue was collected by filtration. Purification by silica gel column chromatography (eluent ratio: petroleum ether/ethyl acetate = 50:1 to 5:1) afforded the target product 2,6-difluoro-3-iodopyridine as a solid (1.49 g, 6.1 mmol, 61% yield). The product was analyzed by ESI-MS (M+1): 242, which is consistent with the theoretically calculated value C5H2F2I (241).
References
[1] European Journal of Organic Chemistry, 2004, # 5, p. 1018 - 1024
[2] Organic Letters, 2007, vol. 9, # 25, p. 5175 - 5178
[3] Tetrahedron Letters, 2004, vol. 45, # 36, p. 6697 - 6701
[4] Patent: WO2009/89263, 2009, A2. Location in patent: Page/Page column 77
[5] Tetrahedron, 2016, vol. 72, # 17, p. 2196 - 2205
2,6-Difluoro-3-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Difluoro-3-iodopyridine manufacturers
- Product
- 2,6-Difluoro-3-iodopyridine 685517-67-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100 kg
- Release date
- 2020-01-10