2,6-dichloropyridin-3-ol
Uses- Product Name
- 2,6-dichloropyridin-3-ol
- CAS No.
- 52764-11-1
- Chemical Name
- 2,6-dichloropyridin-3-ol
- Synonyms
- Einecs 258-163-0;2,6-Dichloro-3-pyridinol;2,6-dichloropyridin-3-ol;2,6-Dichloropyridine-3-ol;3-Pyridinol, 2,6-dichloro-;2,6-Dichloro-3-hydroxypyridine;6-bromo-3,4-dimethylpyridin-2-amine;2,6-dichloropyridin-3-ol ISO 9001：2015 REACH
- CBNumber
- CB7892411
- Molecular Formula
- C5H3Cl2NO
- Formula Weight
- 163.99
- MOL File
- 52764-11-1.mol
2,6-dichloropyridin-3-ol Property
- Boiling point:
- 353.4±37.0 °C(Predicted)
- Density
- 1.561±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 3.86±0.10(Predicted)
- Appearance
- White to light brown Solid
- InChI
- InChI=1S/C5H3Cl2NO/c6-4-2-1-3(9)5(7)8-4/h1-2,9H
- InChIKey
- CDDCESLWCVAQMG-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=CC=C1O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D475908
- Product name
- 2,6-Dichloropyridin-3-ol
- Packaging
- 500mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- HCH0360909
- Product name
- 2,6-DICHLORO-3-HYDROXYPYRIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.68
- Updated
- 2021/12/16
- Product number
- Z0663
- Product name
- 2,6-Dichloro-3-hydroxypyridine
- Packaging
- 10g
- Price
- $1434
- Updated
- 2021/12/16
- Product number
- A147733
- Product name
- 2,6-Dichloropyridin-3-ol
- Purity
- 98%
- Packaging
- 100mg
- Price
- $61
- Updated
- 2021/12/16
- Product number
- A147733
- Product name
- 2,6-Dichloropyridin-3-ol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $97
- Updated
- 2021/12/16
2,6-dichloropyridin-3-ol Chemical Properties,Usage,Production
Uses
2,6-Dichloro-3-hydroxypyridine is a pharmaceutical intermediate, and there are literature reports that it can be used to prepare drugs against HCV infection.
Synthesis
148493-34-9
52764-11-1
Preparation of Compound 1 Step 1 - A solution of 2,6-dichloropyridin-3-ylboronic acid (3 g, 15.71 mmol) in 30 mL of CH2Cl2 was slowly added to H2O2 (1.60 g, 47.12 mmol) at 0°C. The reaction mixture was stirred at room temperature for about 15 hours and then quenched with saturated aqueous NaHCO3 solution. Subsequently, 50 mL of Na2S2O3 aqueous solution was added and the pH was adjusted to <7 with 1 N HCl. The mixture was extracted with EtOAc (40 mL x 3), the organic layers were combined and washed with 100 mL of brine, dried over Na2SO4, filtered and the solvent was evaporated to give 2,6-dichloropyridin-3-ol (2.34 g, yield: 91.4%). The product was confirmed by 1H-NMR (CDCl3, 400MHz): δ 7.30 (d, J = 8.4Hz, 1H), 7.19 (d, J = 8.4Hz, 1H), 5.70 (br, 1H).
References
[1] Tetrahedron, 2005, vol. 61, # 6, p. 1417 - 1421
[2] Patent: WO2013/33900, 2013, A1. Location in patent: Page/Page column 27
[3] Patent: WO2013/33971, 2013, A1. Location in patent: Page/Page column 32-33
[4] Patent: US2014/213571, 2014, A1. Location in patent: Paragraph 0223
2,6-dichloropyridin-3-ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-dichloropyridin-3-ol manufacturers
- Product
- 2,6-dichloropyridin-3-ol 52764-11-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2019-12-25