3-Acetyl-2-fluoropyridine
- Product Name
- 3-Acetyl-2-fluoropyridine
- CAS No.
- 79574-70-2
- Chemical Name
- 3-Acetyl-2-fluoropyridine
- Synonyms
- 3-ACETYL-2-FLUOROPYRIDINE;1-(2-FLUOROPYRIDIN-3-YL) ETHANONE;1-(2-Fluoro-3-pyridinyl)-ethanone;1-(2-Fluoropyridin-3-yl)ethan-1-one;Ethanone, 1-(2-fluoro-3-pyridinyl)-;Ethanone, 1-(2-fluoro-3-pyridinyl)- (9CI);3-Acetyl-2-fluoropyridine ISO 9001：2015 REACH;1-(2-Fluoropyridin-3-yl)ethan-1-one, 3-Ethanoyl-2-fluoropyridine
- CBNumber
- CB5168684
- Molecular Formula
- C7H6FNO
- Formula Weight
- 139.13
- MOL File
- 79574-70-2.mol
3-Acetyl-2-fluoropyridine Property
- Boiling point:
- 85 °C(Press: 10 Torr)
- Density
- 1.175±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.23±0.10(Predicted)
- form
- liquid
- color
- Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- A175910
- Product name
- 3-Acetyl-2-fluoropyridine
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 4H17-3-X8
- Product name
- 3-Acetyl-2-fluoropyridine
- Purity
- 97%
- Packaging
- 100mg
- Price
- $31
- Updated
- 2021/12/16
- Product number
- A1924
- Product name
- 3-Acetyl-2-fluoropyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Y4110
- Product name
- 1-(2-Fluoropyridin-3-yl)ethanone
- Packaging
- 1g
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 4H17-3-X8
- Product name
- 3-Acetyl-2-fluoropyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $117
- Updated
- 2021/12/16
3-Acetyl-2-fluoropyridine Chemical Properties,Usage,Production
Synthesis
79574-61-1
79574-70-2
The general procedure for synthesizing 3-acetyl-2-fluoropyridine from 1-(2-fluoropyridin-3-yl)ethanol was as follows: referring to Example 32, 1-(2-fluoropyridin-3-yl)ethanol (39.9 g) was dissolved in dimethyl sulfoxide (200 mL) and cooled in an ice bath. A suspension of sulfur trioxide pyridine complex (90.0 g) in dimethyl sulfoxide (200 mL) was slowly added dropwise at the same temperature and triethylamine (200 mL) was added. The reaction mixture was gradually warmed to room temperature and stirred at that temperature for 20 hours. Upon completion of the reaction, water was added to the mixture and extracted with ethyl acetate. The organic phases were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate=1:2) to afford the red oily product 3-acetyl-2-fluoropyridine (33.8 g, 86% yield).1H-NMR (CDCl3) δ: 2.69 (3H, dd, J=4.9,1.1 Hz), 7.34 (1H, ddd, J=7.6,4.9,2.3 Hz ), 8.34 (1H, dddd, J=9.5,7.6,2.3,1.1Hz), 8.40 (1H, dddd, J=4.9,2.3,1.1Hz).
References
[1] Patent: US2009/156642, 2009, A1. Location in patent: Page/Page column 40
[2] Journal of Organic Chemistry, 1992, vol. 57, # 2, p. 565 - 573
[3] Journal of Organometallic Chemistry, 1981, vol. 215, # 2, p. 139 - 150
3-Acetyl-2-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Acetyl-2-fluoropyridine manufacturers
- Product
- 3-Acetyl-2-fluoropyridine 79574-70-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26