2-FLUORO-4-IODONICOTINIC ACID
- Product Name
- 2-FLUORO-4-IODONICOTINIC ACID
- CAS No.
- 884494-51-3
- Chemical Name
- 2-FLUORO-4-IODONICOTINIC ACID
- Synonyms
- 2-FLUORO-4-IODONICOTINIC ACID;REF DUPL: 2-fluoro-4-iodonicotinicacid;2-fluoro-4-iodopyridine-3-carboxylic acid;2-Fluoro-4-iodopyridin-3-ylcaboxylic acid;2-Fluoro-4-iodo-3-pyridinecarboxylic acid;3-Pyridinecarboxylic acid, 2-fluoro-4-iodo-;2-Fluoro-4-iodopyridine-3-carboxylic acid, 3-Carboxy-2-fluoro-4-iodopyridine
- CBNumber
- CB2275033
- Molecular Formula
- C6H3FINO2
- Formula Weight
- 267
- MOL File
- 884494-51-3.mol
2-FLUORO-4-IODONICOTINIC ACID Property
- Boiling point:
- 347.0±42.0 °C(Predicted)
- Density
- 2.198
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.20±0.10(Predicted)
- form
- solid
- color
- Off-white
- InChI
- InChI=1S/C6H3FINO2/c7-5-4(6(10)11)3(8)1-2-9-5/h1-2H,(H,10,11)
- InChIKey
- QKPLTGKHTYHYLU-UHFFFAOYSA-N
- SMILES
- C1(F)=NC=CC(I)=C1C(O)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F598810
- Product name
- 2-Fluoro-4-iodonicotinicacid
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 073692
- Product name
- 2-Fluoro-4-iodonicotinic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $79
- Updated
- 2021/12/16
- Product number
- 4H21-K-X1
- Product name
- 2-Fluoro-4-iodonicotinic acid
- Packaging
- 250mg
- Price
- $26
- Updated
- 2021/12/16
- Product number
- 4H21-K-X1
- Product name
- 2-Fluoro-4-iodonicotinic acid
- Packaging
- 500mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 073692
- Product name
- 2-Fluoro-4-iodonicotinic acid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $315
- Updated
- 2021/12/16
2-FLUORO-4-IODONICOTINIC ACID Chemical Properties,Usage,Production
Synthesis
153034-82-3
884494-51-3
The general procedure for the synthesis of 2-fluoro-4-iodonicotinic acid from 2-fluoro-4-iodopyridine-3-carboxaldehyde was as follows: to a stirred solution of 2-fluoro-4-iodopyridine-3-carboxaldehyde (10.0 g, 39.8 mmol) in a solvent mixture of tert-butanol (350 mL) and water (100 mL) at room temperature was added sequentially 2-methyl-2-butene (42.1 mL, 398 mmol) and sodium chlorite (18.0 g, 199 mmol). 398 mmol), sodium phosphate monohydrate (60.5 g, 438 mmol) and sodium chlorite (18.0 g, 199 mmol). The reaction mixture was stirred continuously for 75 minutes at room temperature. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and the pH was adjusted to about 2 by slow addition of 6 M aqueous hydrochloric acid. subsequently, the aqueous layer was extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. Finally, the target product 2-fluoro-4-iodonicotinic acid (10.63 g, 39.8 mmol, 100% yield) was purified by medium pressure liquid chromatography (MPLC) using a gradient elution (100/0 to 80/20) of dichloromethane/methanol (containing 1% acetic acid). Mass spectrum (ESI positive ion mode) m/z: 268 ([M+H]+). exact mass calculated for C6H3FINO2 was 267.
References
[1] Patent: WO2006/116713, 2006, A1. Location in patent: Page/Page column 194-195
[2] Patent: WO2016/95204, 2016, A1. Location in patent: Page/Page column 62; 63
2-FLUORO-4-IODONICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-FLUORO-4-IODONICOTINIC ACID manufacturers
- Product
- 2-FLUORO-4-IODONICOTINIC ACID 884494-51-3
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 500kg
- Release date
- 2020-03-06