2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE

Product Name: 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE
CAS No.: 171366-19-1
Chemical Name: 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE
Synonyms: 2-Fluoro-4-iodo-3-pyridinemethanol;3-Pyridinemethanol,2-fluoro-4-iodo-;(2-Fluoro-4-iodopyridin-3-yl)Methanol;2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE;2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE ISO 9001：2015 REACH
CBNumber: CB5781731
Molecular Formula: C6H5FINO
Formula Weight: 253.01
MOL File: 171366-19-1.mol

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2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE Property

Boiling point:: 330.4±37.0 °C(Predicted)
Density: 2.061
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 12.27±0.10(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Frontier Specialty Chemicals

Product number: Y15328
Product name: 2-Fluoro-3-(hydroxymethyl)-4-iodopyridine
Purity: 98%
Packaging: 1g
Price: $38
Updated: 2021/12/16

Matrix Scientific

Product number: 097318
Product name: (2-Fluoro-4-iodopyridin-3-yl)methanol
Purity: 95+%
Packaging: 250mg
Price: $265
Updated: 2021/12/16

AK Scientific

Product number: J95317
Product name: 2-Fluoro-3-(hydroxymethyl)-4-iodopyridine
Packaging: 1g
Price: $312
Updated: 2021/12/16

Matrix Scientific

Product number: 097318
Product name: (2-Fluoro-4-iodopyridin-3-yl)methanol
Purity: 95+%
Packaging: 1g
Price: $588
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0070531
Product name: 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $1139.99
Updated: 2021/12/16

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2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE Chemical Properties,Usage,Production

Synthesis

113975-22-7

109-94-4

171366-19-1

Example 1 Synthesis of 2-fluoro-4-iodo-3-(hydroxymethyl)pyridine: A solution of LDA was prepared by reacting diisopropylamine (0.63 mL, 4.49 mmol) with n-butyllithium (4.49 mmol) in tetrahydrofuran (THF, 10 mL) at -78 °C and under nitrogen protection. To this solution, a solution of 2-fluoro-3-iodopyridine (1 g, 4.48 mmol) dissolved in THF (2 mL) was added dropwise and stirred for 1 hour at -78 °C. Subsequently, ethyl formate (1.1 mL, 13.6 mmol) was added at the same temperature and stirring was continued for 30 min. The reaction mixture was quenched with saturated sodium bicarbonate solution and slowly warmed to room temperature. Sodium borohydride (0.34 g, 8.99 mmol) was slowly added to the mixture and stirred for 30 minutes before extracting with ethyl acetate. The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by radial preparative thin layer chromatography (silica gel, hexanes, 10% ethyl acetate/hexanes, 20% ethyl acetate/hexanes) to give 708 mg (62% yield) of the target product as a white solid with a melting point of 69°-70 °C. Elemental analysis (C6H5FINO): calculated values: C 28.48, H 1.99, N 5.54; measured values: C 28.55, H 1.94, N 5.48. IR spectrum (KBr, cm^-1): 3336, 1584, 1541, 1446, 1401, 1264, 1218, 1003, 870, 833, 803. 761, 577. 1H NMR (CDCl3): δ 7.79-7.82 (d, 1H, J = 5 Hz), 7.66-7.68 (d, 1H, J = 5 Hz), 4.82-4.86 (d, 2H, J = 7 Hz), 1.99-2.04 (t, 1H, J = 14 Hz). 13C NMR (CDCl3): δ 162.29, 159.05, 147.30, 147.09, 132.79, 132.73, 126.14, 125.73, 114.21, 62.24.

References

[1] Patent: US5496952, 1996, A

2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE Suppliers

China 55 Germany 2 India 2 United Kingdom 1 United States 10 Global 70

Capot Chemical Co., Ltd

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Capot Chemical Co.,Ltd.

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Hebei Huaxing Chemical Co., Ltd

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3A Chemicals

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Shanghai Jizhi Biochemical Technology Co. Ltd.

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View Lastest Price from 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE manufacturers

Dideu Industries Group Limited

Product: 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE 171366-19-1
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-01

Career Henan Chemical Co

Product: 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE 171366-19-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1000kg
Release date: 2020-01-13

171366-19-1, 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINERelated Search:

4-IODO-PYRIDIN-3-OL 4-Iodopyridine 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE 2-FLUORO-4-IODO-3-PICOLINE 2-Fluoro-3-iodopyridine 2-Fluoro-3-methylpyridine 2-FLUORO-4-IODONICOTINIC ACID 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER 4-Iodo-3-methylpyridine 2-FLUORO-3-(HYDROXYMETHYL)PYRIDINE

2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE

(2-Fluoro-4-iodopyridin-3-yl)Methanol

3-Pyridinemethanol,2-fluoro-4-iodo-

2-Fluoro-4-iodo-3-pyridinemethanol

2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE ISO 9001：2015 REACH

171366-19-1

6H5FINO

Pyridines

Boronic Acid

Pyridine