ChemicalBook > CAS DataBase List > 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE

2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE

Product Name
2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE
CAS No.
171366-19-1
Chemical Name
2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE
Synonyms
2-Fluoro-4-iodo-3-pyridinemethanol;3-Pyridinemethanol,2-fluoro-4-iodo-;(2-Fluoro-4-iodopyridin-3-yl)Methanol;2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE;2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE ISO 9001：2015 REACH
CBNumber
CB5781731
Molecular Formula
C6H5FINO
Formula Weight
253.01
MOL File
171366-19-1.mol
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2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE Property

Boiling point:
330.4±37.0 °C(Predicted)
Density 
2.061
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
12.27±0.10(Predicted)
Appearance
Light yellow to yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Frontier Specialty Chemicals
Product number
Y15328
Product name
2-Fluoro-3-(hydroxymethyl)-4-iodopyridine
Purity
98%
Packaging
1g
Price
$38
Updated
2021/12/16
Matrix Scientific
Product number
097318
Product name
(2-Fluoro-4-iodopyridin-3-yl)methanol
Purity
95+%
Packaging
250mg
Price
$265
Updated
2021/12/16
AK Scientific
Product number
J95317
Product name
2-Fluoro-3-(hydroxymethyl)-4-iodopyridine
Packaging
1g
Price
$312
Updated
2021/12/16
Matrix Scientific
Product number
097318
Product name
(2-Fluoro-4-iodopyridin-3-yl)methanol
Purity
95+%
Packaging
1g
Price
$588
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0070531
Product name
2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE
Purity
95.00%
Packaging
1G
Price
$1139.99
Updated
2021/12/16
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2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE Chemical Properties,Usage,Production

Synthesis

113975-22-7

109-94-4

171366-19-1

Example 1 Synthesis of 2-fluoro-4-iodo-3-(hydroxymethyl)pyridine: A solution of LDA was prepared by reacting diisopropylamine (0.63 mL, 4.49 mmol) with n-butyllithium (4.49 mmol) in tetrahydrofuran (THF, 10 mL) at -78 °C and under nitrogen protection. To this solution, a solution of 2-fluoro-3-iodopyridine (1 g, 4.48 mmol) dissolved in THF (2 mL) was added dropwise and stirred for 1 hour at -78 °C. Subsequently, ethyl formate (1.1 mL, 13.6 mmol) was added at the same temperature and stirring was continued for 30 min. The reaction mixture was quenched with saturated sodium bicarbonate solution and slowly warmed to room temperature. Sodium borohydride (0.34 g, 8.99 mmol) was slowly added to the mixture and stirred for 30 minutes before extracting with ethyl acetate. The organic phases were combined, washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by radial preparative thin layer chromatography (silica gel, hexanes, 10% ethyl acetate/hexanes, 20% ethyl acetate/hexanes) to give 708 mg (62% yield) of the target product as a white solid with a melting point of 69°-70 °C. Elemental analysis (C6H5FINO): calculated values: C 28.48, H 1.99, N 5.54; measured values: C 28.55, H 1.94, N 5.48. IR spectrum (KBr, cm^-1): 3336, 1584, 1541, 1446, 1401, 1264, 1218, 1003, 870, 833, 803. 761, 577. 1H NMR (CDCl3): δ 7.79-7.82 (d, 1H, J = 5 Hz), 7.66-7.68 (d, 1H, J = 5 Hz), 4.82-4.86 (d, 2H, J = 7 Hz), 1.99-2.04 (t, 1H, J = 14 Hz). 13C NMR (CDCl3): δ 162.29, 159.05, 147.30, 147.09, 132.79, 132.73, 126.14, 125.73, 114.21, 62.24.

References

[1] Patent: US5496952, 1996, A

2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE Suppliers

China 55 Germany 2 India 2 United Kingdom 1 United States 10 Global 70
A.J Chemicals
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sales@ajchem.in
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India
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CHEMSWORTH
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India
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View Lastest Price from 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE manufacturers

Dideu Industries Group Limited
Product
2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE 171366-19-1
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-01
Career Henan Chemical Co
Product
2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE 171366-19-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000kg
Release date
2020-01-13

171366-19-1, 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINERelated Search:

4-IODO-PYRIDIN-3-OL 4-Iodopyridine 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE 2-FLUORO-4-IODO-3-PICOLINE 2-Fluoro-3-iodopyridine 2-Fluoro-3-methylpyridine 2-FLUORO-4-IODONICOTINIC ACID 2-FLUORO-4-IODONICOTINIC ACID METHYL ESTER 4-Iodo-3-methylpyridine 2-FLUORO-3-(HYDROXYMETHYL)PYRIDINE

  • 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE
  • (2-Fluoro-4-iodopyridin-3-yl)Methanol
  • 3-Pyridinemethanol,2-fluoro-4-iodo-
  • 2-Fluoro-4-iodo-3-pyridinemethanol
  • 2-FLUORO-3-(HYDROXYMETHYL)-4-IODOPYRIDINE ISO 9001：2015 REACH
  • 171366-19-1
  • 6H5FINO
  • Pyridines
  • Boronic Acid
  • Pyridine