5-Fluoro-2-forMylpyridine
Uses Application- Product Name
- 5-Fluoro-2-forMylpyridine
- CAS No.
- 31181-88-1
- Chemical Name
- 5-Fluoro-2-forMylpyridine
- Synonyms
- 5-Fluoropiconaldehyde;5-fluoropicolinaldehyde;5-FLUORO-2-FORMYLPYRIDINE;5-Fluoro-2-pyridinecarbaldehyde;5-Fluoropyridine-2-carboxaldehyde;5-FLUORO-2-PYRIDINE CARBOXALDEHYDE;2-Pyridinecarboxaldehyde,5-fluoro-;2-Pyridinecarboxaldehyde,5-fluoro-(9CI);5-Fluoro-2-formylpyridine, 5-Fluoropicolinaldehyde
- CBNumber
- CB9292143
- Molecular Formula
- C6H4FNO
- Formula Weight
- 125.1
- MOL File
- 31181-88-1.mol
5-Fluoro-2-forMylpyridine Property
- Boiling point:
- 174℃
- Density
- 1.269
- Flash point:
- 59℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 1.30±0.10(Predicted)
- form
- solid
- color
- White to yellow
- InChI
- InChI=1S/C6H4FNO/c7-5-1-2-6(4-9)8-3-5/h1-4H
- InChIKey
- IACCXWQKIQUVFQ-UHFFFAOYSA-N
- SMILES
- C1(C=O)=NC=C(F)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- F532100
- Product name
- 5-Fluoro-2-formylpyridine
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- F532100
- Product name
- 5-Fluoro-2-formylpyridine
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- PC7042
- Product name
- 5-Fluoropyridine-2-carboxaldehyde
- Packaging
- 5g
- Price
- $174
- Updated
- 2021/12/16
- Product number
- F1879
- Product name
- 5-Fluoro-2-formylpyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 4H15-3-X8
- Product name
- 5-Fluoropyridine-2-carboxaldehyde
- Purity
- 95%
- Packaging
- 5G
- Price
- $308
- Updated
- 2021/12/16
5-Fluoro-2-forMylpyridine Chemical Properties,Usage,Production
Uses
5-Fluoropyridine-2-aldehyde is a pyridine derivative with diverse chemical reactivity. It can undergo aromatic nucleophilic substitution, condensation, addition and other chemical reactions, and is mainly used as an intermediate in organic synthesis and a raw material for pharmaceutical chemicals.
Application
5-Fluoropyridine-2-aldehyde exhibits high chemical reactivity and is mainly used as an intermediate in organic synthesis and a raw material in pharmaceutical chemistry. It has certain applications in the synthesis of pyridine-based functional organic molecules. For example, some literature reports that this substance can be used in the preparation of pyridine-based antimalarial compounds.
Synthesis
148541-70-2
31181-88-1
The general procedure for the synthesis of 5-fluoropyridine-2-carboxylic acid from ethyl 5-fluoropyridine-2-carboxylate is as follows: 5-fluoropyridine-2-carboxylic acid (200 mg, 1.13 mmol) was reacted with ethanol (6 mL) and a dioxane solution of 4M HCl (0.5 mL) for 20 hours at 90°C. After completion of the reaction, the mixture was concentrated and mixed with saturated sodium carbonate solution and dichloromethane. The organic layer was separated, washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give ethyl 5-fluoropyridine-2-carboxylate (94 mg, 49.3% yield). Subsequently, ethyl 5-fluoropyridine-2-carboxylate (94 mg, 0.556 mmol) was dissolved in dichloromethane (4.0 mL) at room temperature, and a toluene solution of 1M DIBAL (1.23 mL, 1.23 mmol) was slowly added. The reaction mixture was stirred for 30 min, then the reaction was quenched with 2 M sodium carbonate solution and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude product 5-fluoropyridine-2-carboxaldehyde (39 mg, 54.7% yield), which could be used directly in the subsequent reaction without further purification.GC-MS analysis showed a molecular ion peak (M+) of 125.
References
[1] Patent: WO2004/14902, 2004, A2. Location in patent: Page 42
[2] Patent: WO2009/58298, 2009, A1. Location in patent: Page/Page column 139
[3] Patent: WO2009/58299, 2009, A1. Location in patent: Page/Page column 55-56
[4] Patent: WO2010/111058, 2010, A1. Location in patent: Page/Page column 65
[5] Patent: WO2010/111059, 2010, A1. Location in patent: Page/Page column 50
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View Lastest Price from 5-Fluoro-2-forMylpyridine manufacturers
- Product
- 5-Fluoropicolinaldehyde 31181-88-1
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-17
- Product
- 2-BROMO-3-FLUOROPYRIDINE 31181-88-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 5-Fluoro-2-forMylpyridine 31181-88-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-19