ChemicalBook > CAS DataBase List > 5-Aminonicotinic acid

5-Aminonicotinic acid

Product Name
5-Aminonicotinic acid
CAS No.
24242-19-1
Chemical Name
5-Aminonicotinic acid
Synonyms
AURORA KA-3032;JACS-24242-19-1;AKOS BBS-00001362;IFLAB-BB F1926-0005;5-Ammonionicotinate;5-Aminonicotinic aci;OTAVA-BB BB7017520056;5-AMINONICOTINIC ACID;5-AMINOISOPHTHALICACID;5-AMINOSONICOTINICACID
CBNumber
CB0248990
Molecular Formula
C6H6N2O2
Formula Weight
138.12
MOL File
24242-19-1.mol
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5-Aminonicotinic acid Property

Melting point:
293 °C
Boiling point:
253.51°C (rough estimate)
Density 
1.3471 (rough estimate)
refractive index 
1.5100 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
2.36±0.10(Predicted)
form 
Crystalline Powder
color 
Golden-brown
BRN 
115848
InChI
InChI=1S/C6H6N2O2/c7-5-1-4(6(9)10)2-8-3-5/h1-3H,7H2,(H,9,10)
InChIKey
BYIORJAACCWFPU-UHFFFAOYSA-N
SMILES
C1=NC=C(N)C=C1C(O)=O
CAS DataBase Reference
24242-19-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-20/21/22-22
Safety Statements 
36/37/39-26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
672513
Product name
5-Aminopyridine-3-carboxylic acid
Purity
97%
Packaging
1g
Price
$94.5
Updated
2025/07/31
Sigma-Aldrich
Product number
672513
Product name
5-Aminopyridine-3-carboxylic acid
Purity
97%
Packaging
5g
Price
$541
Updated
2023/06/20
TCI Chemical
Product number
A2000
Product name
5-Aminonicotinic Acid
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$38
Updated
2025/07/31
TCI Chemical
Product number
A2000
Product name
5-Aminonicotinic Acid
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$152
Updated
2025/07/31
TRC
Product number
A618753
Product name
5-Aminonicotinic Acid
Packaging
500mg
Price
$60
Updated
2021/12/16
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5-Aminonicotinic acid Chemical Properties,Usage,Production

Chemical Properties

Off-white Cryst

Uses

5-Aminonicotinic acid is used in the synthesis of coordination polymers, bioluminescent reagents and biological active agents.

Definition

ChEBI: 5-aminonicotinic acid is an aminonicotinic acid in which the amino group is situated at position 5 of the pyridine ring. It has a role as a metabolite. It is an aromatic amine, an aminopyridine and an aminonicotinic acid. It is functionally related to a nicotinic acid.

Synthesis

20826-04-4

24242-19-1

The general procedure for the synthesis of 5-aminonicotinic acid from 5-bromonicotinic acid was as follows: 5-bromo-3-pyridinecarboxylic acid (25 g, 0.124 mol) was mixed with ammonia (67.32 mL) and copper sulfate pentahydrate (8.41 g) was added. The reaction mixture was transferred to an autoclave, heated to 120 °C and kept for 16 hours. The reaction process was monitored by thin layer chromatography (TLC) using ninhydrin as a color developer. Upon completion of the reaction, the reaction mixture was washed with saturated sodium sulfide solution to remove copper ions, followed by adjusting the pH to 4-5 with concentrated hydrochloric acid.The acidified mixture was cooled to precipitate solids. The solid product was collected by filtration and dried to give 5-aminonicotinic acid (12.9 g, 74% yield).

References

[1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6340 - 6350
[2] Patent: WO2004/35545, 2004, A2. Location in patent: Page 46
[3] Patent: WO2003/101959, 2003, A1. Location in patent: Page 50-51
[4] Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1981, vol. 35, # 4, p. 289 - 294
[5] Journal of the American Chemical Society, 1948, vol. 70, p. 2381,2383

5-Aminonicotinic acid Preparation Products And Raw materials

Raw materials

Nicotinic acid Sodium sulfide nonahydrate Ninhydrin hydrate Ammonium hydroxide 5-Bromonicotinic acid Sodium sulfide 3-Bromoquinoline Copper(II) sulfate pentahydrate Nitric acid Bromine Thionyl chloride

Preparation Products

(5-Fluoropyridin-3-yl)methanol ,97% 3-AMINO-5-HYDROXYMETHYLPYRIDINE 5-HYDROXY-NICOTINIC ACID ETHYL ESTER 5-AMINO-3-PYRIDINECARBOXAMIDE 5-ACETAMIDONICOTINIC ACID METHYL 5-FLUOROPYRIDINE-3-CARBOXYLATE ETHYL 5-FLUORONICOTINATE 5-AMINO-3-PYRIDINEMETHANAMINE Ethyl 5-aminopyridine-3-carboxylate ,97% 5-Hydroxynicotinic acid Methyl 5-hydroxynicotinate 5-AMINO-3-PYRIDINECARBONITRILE
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View Lastest Price from 5-Aminonicotinic acid manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
5-Aminonicotinic acid 24242-19-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-10-09
Shijiazhuang Dowell Chemical Co.,Ltd
Product
5-Aminonicotinic acid 24242-19-1
Price
US $0.00-0.00/KG
Min. Order
0.1KG
Purity
98%
Supply Ability
500KG/month
Release date
2024-12-10
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
5-Ammonionicotinate 24242-19-1
Price
US $20.00/Kg/Bag
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2021-09-23

24242-19-1, 5-Aminonicotinic acidRelated Search:

EC 2.6.1.2 Acetaminophen Aminopyrine Glucosamine EPA Sulfamic acid Folic acid N,N-Dimethylpropionamide 2,2-Dimethylbutyryl chloride 2-Phenylbutyric acid Citric acid Ascoric Acid 5-NITRONICOTINIC ACID 5-(METHYLAMINO)NICOTINIC ACID 2-Amino-5-nitronicotinic acid Methyl-6-chloro-5-nitronicotinate 4-Aminonicotinic acid 99%,4-AMINONICOTINIC ACID 6-Aminonicotinic acid, 98+%,6-Aminonicotinic acid 98%,6-Aminonicotinic acid;6-Aminopyridine-3-carboxylic acid,6-AMINONICOTINIC ACID

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