3-AMINO-5-HYDROXYMETHYLPYRIDINE
- Product Name
- 3-AMINO-5-HYDROXYMETHYLPYRIDINE
- CAS No.
- 443649-18-1
- Chemical Name
- 3-AMINO-5-HYDROXYMETHYLPYRIDINE
- Synonyms
- (5-amino-3-pyridyl)methanol;3-PyridineMethanol,5-aMino-;(5-Aminopyridin-3-yl)methanol;3-AMINO-5-HYDROXYMETHYLPYRIDINE;3-Pyridinemethanol,5-amino-(9CI);5-Amino-3-(Hydroxymethyl)Pyridine;3-Amino-5-hydroxymethylpyridine ,97%;3-AMINO-5-HYDROXYMETHYLPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB0482943
- Molecular Formula
- C6H8N2O
- Formula Weight
- 124.14
- MOL File
- 443649-18-1.mol
3-AMINO-5-HYDROXYMETHYLPYRIDINE Property
- Boiling point:
- 367.2±27.0 °C(Predicted)
- Density
- 1.257
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 13.61±0.10(Predicted)
- Appearance
- White to yellow Solid
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A630050
- Product name
- (5-Aminopyridin-3-yl)methanol
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- Z2689
- Product name
- 3-Amino-5-hydroxymethylpyridine
- Packaging
- 1g
- Price
- $286
- Updated
- 2021/12/16
- Product number
- FA142764
- Product name
- (5-Aminopyridin-3-yl)methanol
- Packaging
- 2g
- Price
- $369
- Updated
- 2021/12/16
- Product number
- FA142764
- Product name
- (5-Aminopyridin-3-yl)methanol
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- JK172022
- Product name
- 3-Amino-5-hydroxymethylpyridine
- Purity
- 97%
- Packaging
- 250mg
- Price
- $71
- Updated
- 2021/12/16
3-AMINO-5-HYDROXYMETHYLPYRIDINE Chemical Properties,Usage,Production
Chemical Properties
White to light yellow solid
Synthesis
36052-25-2
443649-18-1
General procedure for the synthesis of 5-aminopyridine-3-methanol from 5-aminopyridine-3-carboxylic acid methyl ester: 5-aminopyridine-3-carboxylic acid methyl ester (5.7 g, 30.2 mmol) was dissolved in tetrahydrofuran (THF, 150 mL) and lithium aluminum hydroxide (LiAlH4, 1 M THF solution, 133 mL, 133 mmol) was added slowly at 0 °C. The reaction mixture was stirred at room temperature for 21 hours. Upon completion of the reaction, the reaction mixture was quenched with dilute hydrochloric acid (HCl) and acidified to pH 3, followed by alkalization with solid sodium carbonate (Na2CO3) to pH 8. The solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography using 20% methanol (MeOH)/dichloromethane (DCM) as eluent to afford the target product 5-aminopyridine-3-methanol (3.8 g, 100% yield), which was analyzed by liquid chromatography coupled with mass spectrometry (LCMS) showing a purity of 97% with a mass-to-charge ratio (m/z) of 125 [M+H]+ and the detector was an evaporative light scattering detector (ELS).
References
[1] Patent: WO2006/117549, 2006, A1. Location in patent: Page/Page column 97
[2] Chemistry - A European Journal, 2002, vol. 8, # 5, p. 1218 - 1226
[3] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 17, p. 6340 - 6350
[4] Patent: WO2018/13774, 2018, A1. Location in patent: Page/Page column 256; 257
3-AMINO-5-HYDROXYMETHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-AMINO-5-HYDROXYMETHYLPYRIDINE manufacturers
- Product
- 3-AMINO-5-HYDROXYMETHYLPYRIDINE 443649-18-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12