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(6-AMINO-3-PYRIDINYL)METHANOL

Product Name
(6-AMINO-3-PYRIDINYL)METHANOL
CAS No.
113293-71-3
Chemical Name
(6-AMINO-3-PYRIDINYL)METHANOL
Synonyms
2-Amino-5-hydroxymethyL;Abemaciclib Impurity 33;2-Amino-5-pyridinemethanol;2-AMinopyridine-5-Methanol;(6-aminopyridin-3-yl)metha;(6-Amino-3-pyridyl)methanol;2-Amino-5-hydroxymethylpy...;3-Pyridinemethanol, 6-amino-;(6-AMINO-3-PYRIDINYL)METHANOL;2-Aminopyridine-5-methanol,97%
CBNumber
CB0176628
Molecular Formula
C6H8N2O
Formula Weight
124.14
MOL File
113293-71-3.mol
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(6-AMINO-3-PYRIDINYL)METHANOL Property

Melting point:
120 °C
Boiling point:
320.2±27.0 °C(Predicted)
Density 
1.257±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
powder to crystal
pka
13.61±0.10(Predicted)
color 
White to Light yellow to Light orange
Water Solubility 
Sparingly soluble in water.(0.26 g/L) (25°C),
InChI
InChI=1S/C6H8N2O/c7-6-2-1-5(4-9)3-8-6/h1-3,9H,4H2,(H2,7,8)
InChIKey
TXPRFSOGPYITOT-UHFFFAOYSA-N
SMILES
C1=NC(N)=CC=C1CO
CAS DataBase Reference
113293-71-3
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
22-36/37/38-20/21/22
Safety Statements 
22-26-36/37/39
RIDADR 
2811
Hazard Note 
Irritant
HS Code 
29221990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
MNO000168
Product name
2-Amino-5-pyridinemethanol
Packaging
1g
Price
$179
Updated
2025/07/31
TCI Chemical
Product number
A3148
Product name
2-Amino-5-pyridinemethanol
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$113
Updated
2025/07/31
TRC
Product number
A615648
Product name
(6-Aminopyridin-3-yl)methanol
Packaging
500mg
Price
$130
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-1-VG
Product name
2-Amino-5-(hydroxymethyl)pyridine
Purity
97%
Packaging
1g
Price
$84
Updated
2021/12/16
Apolloscientific
Product number
OR14503
Product name
2-Amino-5-(hydroxymethyl)pyridine
Purity
97%
Packaging
250mg
Price
$24
Updated
2021/12/16
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(6-AMINO-3-PYRIDINYL)METHANOL Chemical Properties,Usage,Production

Chemical Properties

White to light yellow solid

Uses

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor.

Synthesis

3167-49-5

113293-71-3

1. Concentrated sulfuric acid (0.95 mL, 17.2 mmol, 0.5 eq.) was slowly added to a solution of 6-aminonicotinic acid (5.0 g, 34.4 mmol) in ethanol (50 mL). 2. The reaction mixture was heated and refluxed for 16 h. 3. Upon completion of the reaction the mixture was carefully poured into a concentrated aqueous solution of Na2CO3 to neutralize. 4. The aqueous phases were extracted three times using EtOAc. 5. The organic layers were combined, washed with saturated brine, dried over anhydrous Na2SO4, filtered, and concentrated under reduced pressure.6 The concentrated residue was dissolved in anhydrous THF (25 mL).7 Lithium aluminium hydride (2.68 g, 68.6 mmol, 3.0 eq.) was added slowly at -60 °C.8 The reaction mixture was gradually warmed to 0 °C, followed by refluxing for 1 h. The reaction was completed by cooling to room temperature and then refluxing for 1 h. The reaction was completed by cooling to room temperature. At the end of the reaction, the reaction was cooled to room temperature and quenched by the addition of water (1.5 mL) and 5N aqueous NaOH (1.5 mL). 10. The precipitate was removed by filtration, and the filtrate was concentrated under reduced pressure. 11. The residue was purified by fast column chromatography (eluent: EtOAc/MeOH 95:5) to afford the target product, 6-amino-3-pyridinemethanol (2.15 g, 72% yield). 12. The structure of the product was determined by 1.5 mL of fast column chromatography (eluent: EtOAc/MeOH 95:5). The product structure was confirmed by 1H NMR and mass spectrometry: 1H NMR (400 MHz, d6-DMSO): δ= 7.82 (d, J = 1.7 Hz, 1H), 7.32 (dd, J = 8.3/2.5 Hz, 1H), 6.40 (dd, J = 9.3/1.0 Hz, 1H), 5.77 (br s, 2H), 4.88 ( t, J = 5.5 Hz), 4.88 (br s, 2H), 4.88 (t, J = 5.5 Hz, 4.88), 4.88 ( t, J = 5.5 Hz, 1H), 4.27 (d, J = 5.5 Hz, 2H). MS (ES+): 125 (M + H)+.

References

[1] Patent: WO2008/74752, 2008, A2. Location in patent: Page/Page column 27-28
[2] Patent: EP1798221, 2007, A1. Location in patent: Page/Page column 32
[3] Patent: EP1956013, 2008, A1. Location in patent: Page/Page column 30-31
[4] Patent: US2007/99930, 2007, A1. Location in patent: Page/Page column 42
[5] Patent: WO2013/13817, 2013, A1

(6-AMINO-3-PYRIDINYL)METHANOL Preparation Products And Raw materials

Raw materials

2-Amino-5-methylpyridine Ammonium hydroxide Ethanol Acetic anhydride Tetrahydrofuran Benzene Sulfuryl chloride Lithium Aluminum Hydride Hydrochloric acid Potassium permanganate Sodium hydroxide Thionyl chloride

Preparation Products

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(6-AMINO-3-PYRIDINYL)METHANOL Suppliers

Americas 1 Belgium 1 China 149 Europe 2 France 1 Germany 2 India 3 Japan 1 United Kingdom 3 United States 16 Global 179
Shanghai Rlavie Technology Co., Ltd.
Tel
21-67759270 17717059219
Fax
QQ：1479352695
Email
sales@rlavie.com
Country
China
ProdList
1620
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55
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
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55
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
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66
Tetranov Biopharm
Tel
13526569071
Email
sales@leadmedpharm.com
Country
China
ProdList
7892
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64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
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64
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
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Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
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Wuhan ariel chemical Co., LTD.
Tel
18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
3763
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View Lastest Price from (6-AMINO-3-PYRIDINYL)METHANOL manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
(6-AMINO-3-PYRIDINYL)METHANOL 113293-71-3
Price
US $10.00-95.00/KG
Min. Order
1KG
Purity
0.98
Supply Ability
20 tons
Release date
2023-09-28
Henan Fengda Chemical Co., Ltd
Product
(6-Amino-3-pyridinyl)methanol 113293-71-3
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-02
Shanghai Rlavie Technology Co ltd
Product
(6-Amino-pyridin-3-yl)methanol 113293-71-3
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
100kgs/month
Release date
2021-11-27

113293-71-3, (6-AMINO-3-PYRIDINYL)METHANOLRelated Search:

6-(1H-Pyrazol-1-yl)nicotinic acid 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID 6-Aminonicotinic acid Methyl 6-(1H-pyrazol-1-yl)pyridine-3-carboxylate (2-AMINO-3-PYRIDINYL)METHANOL 3-Pyridinemethanol METHYL 6-(1H-IMIDAZOL-1-YL)NICOTINATE 6-(1H-Pyrrol-1-yl)pyridine-3-carboxylic acid 6-(1H-IMIDAZOL-1-YL)NICOTINIC ACID DIETHYL 2-HYDROXY-6-(2-PHENYLHYDRAZINO)-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-AMINO-6-(2-ISONICOTINOYLHYDRAZINO)-3,5-PYRIDINEDICARBOXYLATE 7-(dimethylamino)-4-methoxy-1-methyl-1,8-naphthyridin-2(1H)-one DIETHYL 2-(3,5-DIMETHYL-1H-PYRAZOL-1-YL)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-(2-[1-(6-FLUORO-2-PYRIDINYL)-4-PIPERIDINYLIDENE]HYDRAZINO)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-HYDROXY-6-[2-(1-METHYL-4-PIPERIDINYLIDENE)HYDRAZINO]-3,5-PYRIDINEDICARBOXYLATE DIETHYL 2-HYDROXY-6-(2-[1-(4-NITROPHENYL)-4-PIPERIDINYLIDENE]HYDRAZINO)-3,5-PYRIDINEDICARBOXYLATE 2-AMINO-7,7-DIMETHYL-7,8-DIHYDRO-5H-PYRANO[4,3-B]PYRIDINE-3-CARBOXYLIC ACID DIETHYL 2-(2-(1-[2,6-DINITRO-4-(TRIFLUOROMETHYL)PHENYL]-4-PIPERIDINYLIDENE)HYDRAZINO)-6-HYDROXY-3,5-PYRIDINEDICARBOXYLATE

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